Clinical trials: sponsored by Tongji Hospital
Hepatocellular Carcinoma (HCC)
Tislelizumab Combined With Huaier Granule as First-line Treatment for Unresectable Hepatocellular Carcinoma
This study is a single-arm prospective clinical trial that enrolled 94 patients with unresectable hepatocellular carcinoma(HCC) who received first-line treatment with tislelizumab combined with Huaier granule.
- Trial name
- NCT07413354
- Testing
- Tislelizumab plus Huaier granule
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Tongji Hospital
Remimazolam, Total Intravenous Anesthesia
Remimazolam TIVA-Flumazenil Antagonism in Short-duration ENT Surgeries
This study plans to categorize patients who underwent short-duration ENT surgeries with remimazolam TIVA combined with flumazenil antagonism based on whether their intraoperative BIS values were maintained below 60.
- Conditions
- Remimazolam, Total Intravenous Anesthesia, Bispectral Index
- Trial name
- TIVA (NCT07389798)
- Where
- China
- Volunteers
- 511 people
- Sponsor
- Tongji Hospital
Ultrasound Therapy; Complications
Ultrasound-assisted Versus Real-time Ultrasound-guided Combined Spinal-epidural Anesthesia in Elderly Patients
This prospective randomized controlled trial aims to compare the clinical efficacy and safety of real-time ultrasound guidance (US-RTG) versus static ultrasound-assisted mapping (US-AS) for combined spinal-epidural anesthesia…
- Trial name
- NCT06241716
- Testing
- Ultrasound-assisted localization, US-AS, Real-time ultrasound guidance, US-RTG
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Tongji Hospital
Postoperative Cough, Cough Hypersensitivity Syndrome
Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough
Numerous current studies have indicated that transecting the pulmonary plexus nerve as a routine step in radical lung cancer surgery is an independent risk factor for cough hypersensitivity (CH).
- Trial name
- ENERGY-COUGH (NCT07524712)
- Testing
- Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Tongji Hospital
Constipation
Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease
Comparison of Circular(Soave)and Heart-shaped Anastomosis in Hirschsprung's disease.
- Trial name
- NCT02234219
- Testing
- Heart-shape anastomosis, Soave anastomosis
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Tongji Hospital
Urea Cycle Disorders
A Clinical Study of Glycerol Phenylbutyrate in Chinese Patients With Urea Cycle Disorders
Urea cycle disorders (UCD) are rare diseases in China, would lead to high mortality and disability, which require long-term management due to the recurrent symptoms.
- Trial name
- NCT06904027
- Testing
- Glycerol phenylbutyrate Oral Liquid
- Where
- 5 sites in China
- Volunteers
- 40 people
- Sponsor
- Tongji Hospital
Systemic Scleroderma
Efficacy and Safety of Firsekibart in the Treatment of Systemic Sclerosis
This study is a single-center, single-arm, open-label, exploratory clinical trial. A total of 30 patients with diffuse cutaneous systemic sclerosis (dcSSc) will be enrolled.
- Trial name
- NCT07502105
- Testing
- Firsekibart injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tongji Hospital
HCC - Hepatocellular Carcinoma, TP53 Gene Mutation
A Clinical Trial of Firsekibart, Tislelizumab, and Lenvatinib in Patients With Unresectable, TP53-Mutated Hepatocellular Carcinoma
This study aims to evaluate the effectiveness and safety of a combination therapy with Fuxinqibai monoclonal antibody, Tislelizumab, and Lenvatinib in patients with advanced, unresectable TP53-mutated hepatocellular carcinoma…
- Conditions
- HCC - Hepatocellular Carcinoma, TP53 Gene Mutation, Unresectable, Resistant Cancer
- Trial name
- NCT07535840
- Testing
- Firsekibart + Tislelizumab + Lenvatinib
- Volunteers
- 25 people
- Sponsor
- Tongji Hospital
Hepatocellular Carcinoma (HCC), Metastases
Local Consolidation After Sintilimab Plus Lenvatinib for Metastatic Liver Cancer
This study evaluates whether comprehensive local consolidative therapy added to continued sintilimab plus lenvatinib improves survival compared with continued sintilimab plus lenvatinib alone in patients with oligo-extrahepatic…
- Trial name
- NCT07537946
- Testing
- Sintilimab, Lenvatinib, Comprehensive Local Consolidative Therapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tongji Hospital
Hepatocellular Carcinoma (HCC), Bone Metastases
Denosumab Strategy for Liver Cancer With Bone Metastases
This study will evaluate whether starting denosumab early, together with a locked uniform PD-1-based systemic therapy, can reduce skeletal-related events and delay worsening bone pain compared with a delayed/rescue bone-modifying…
- Trial name
- NCT07537972
- Testing
- Denosumab, Sintilimab, Delayed/Rescue Bone-Modifying Strategy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tongji Hospital
Hepatocellular Carcinoma (HCC), Metastasis
Surgery Plus Systemic Therapy for Liver Cancer With Extrahepatic Metastases
This study will evaluate whether resection of the primary liver tumor, in addition to standard first-line systemic therapy, improves survival in patients with hepatocellular carcinoma that has spread outside the liver but still…
- Trial name
- NCT07537959
- Testing
- Primary Tumor Resection, Protocol-Allowed First-Line Immune-Based Systemic Therapy
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Tongji Hospital
Highly Sensitized Patients Awaiting Kidney Transplant
CAR-T Therapy Targeting CD19 and BCMA in Highly Sensitized Kidney Transplant Participants
The purpose of this study is to assess the safety, tolerability, and efficacy of AZD0120 in highly sensitized adult participants with ESKD awaiting kidney transplant-who, as assessed by investigators, are improbable…
- Trial name
- NCT07350837
- Testing
- AZD0120
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Tongji Hospital
Radiation-Induced Bladder Injury
Study on Biomarkers of Radiation-Induced Bladder Injury
1. To identify biomarkers of radiation-induced bladder injury; 2. To develop a predictive model for radiation-induced bladder injury.
- Trial name
- NCT07528313
- Volunteers
- 220 people
- Sponsor
- Tongji Hospital
Radiation-induced Intestinal Injury
Study on Biomarkers of Radiation-Induced Intestinal Injury
1. To identify biomarkers of radiation-induced intestinal injury; 2. To develop a predictive model for radiation-induced intestinal injury.
- Trial name
- NCT07528287
- Volunteers
- 220 people
- Sponsor
- Tongji Hospital
Adenoidectomy, Tonsillectomy
Effects of Adenoidectomy on Symptoms and IgE Levels in Children With AR
This study aims to evaluate the effects of conservative management versus surgical intervention (adenoidectomy alone or adenotonsillectomy) on symptoms and local IgE levels in children with allergic rhinitis (AR) accompanied with…
- Conditions
- Adenoidectomy, Tonsillectomy, Allergic Rhinitis
- Trial name
- NCT07527260
- Testing
- Drug therapy (NASONEX nasal spray), Adenoidectomy, Adenotonsillectomy
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Tongji Hospital
Gall Stones, Gall Stones (& [Calculus - Gall Bladder])
A Study on the Efficacy and Safety of Endoscopic Ultrasound-guided Gastro-/Duodeno-cholecystostomy for the Treatment of Gallstones.
Gallstones, as a common benign gallbladder disease worldwide, have a prevalence of approximately 6.1%. Although laparoscopic cholecystectomy (LC) is currently the mainstream treatment, its associated complications cannot be…
- Trial name
- NCT07522385
- Testing
- cholecystolithotomy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
EBV-associated Haematologic Neoplasms
KSD-101 Therapy for EBV-associated Haematologic Neoplasms: an Exploratory Clinical Trial
The primary objectives of this study is to evaluate the tolerability and safety of KSD-101 in Patients with EBV-associated haematologic neoplasms, observe the dose-limiting toxicity (DLT) and and to explore the maximum tolerated…
- Trial name
- NCT05635591
- Testing
- Autologous monocyte - derived DCs pulsed with EBV antigen
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Tongji Hospital
Lobectomy
Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection
Combining tegileridine PCIA with ICNB targeting peripheral nerves, may constitute an ideal analgesic model with complementary advantages.
- Trial name
- NCT07386626
- Testing
- Tegileridine, Intercostal Nerve Block, Sufentanil
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Tongji Hospital
Hepatocellular Carcinoma (HCC), Hepatocellular Carcinoma Recurrent
GNB4 and Riplet Gene Methylation Combined Detection Kit for Hepatocellular Carcinoma Recurrence Monitoring
This is a prospective, multicenter, observational longitudinal study designed to evaluate the clinical performance of the GNB4 and Riplet Gene Methylation Combined Detection Kit (Real-time PCR) for monitoring recurrence after…
- Trial name
- CCGLC-019 (NCT07489768)
- Testing
- GNB4 and Riplet Gene Methylation Combined Detection Kit (Real-time PCR)
- Volunteers
- 162 people
- Sponsor
- Tongji Hospital
Advanced Biliary Tract Carcinoma
Adebrelimab Combined With Gemcitabine, Cisplatin, and Simvastatin for Advanced Biliary Tract Cancer
This study will investigate the safety and effectiveness of a new combination treatment for patients with advanced bile duct cancer.
- Trial name
- NCT07392541
- Testing
- Adebrelimab, Gemcitabine + Cisplatin, Simvastatin 20mg
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Tongji Hospital