Clinical trials: sponsored by Tongji Hospital
Cranial Diseases (e.g., Brain Tumors, Stroke, Neurodegenerative Disorders)
Construction of AI Model for Precision Imaging Diagnosis of Cranial Diseases
The goal of this observational study is to develop and validate a high-precision AI diagnostic model for cranial diseases by integrating clinical knowledge systems (pathophysiological classification, age stratification, and…
- Trial name
- NCT07446842
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Rheumatoid Arthritis
Efficacy and Safety of Ivarmacitinib Monotherapy in the Treatment of csDMARDs-IR Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting small joints, with a global prevalence of 0.5%-1.0% and 0.42% in China (around 5 million patients, mostly female and over 55).
- Trial name
- NCT07452445
- Testing
- Ivarmacitinib
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Cholecystectomy
PEG Laxatives for Intestinal Preparation and Gut Microbiota in Cholecystectomy
This observational study aims to investigate the impact of polyethylene glycol (PEG) laxatives used for bowel preparation on the gut microbiota of patients who have undergone cholecystectomy.
- Trial name
- NCT07439640
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Gynecological Day Surgery
Osellidine is Used for Analgesia During Daytime Hysteroscopic Surgery
While providing equivalent analgesic efficacy, oxelidine significantly reduces the risk of adverse reactions-including respiratory depression, gastrointestinal dysfunction, and cognitive impairment-and facilitates faster recovery…
- Trial name
- NCT07409311
- Testing
- Oxelidine, Sufentanil or Remifentanil
- Volunteers
- 310 people
- Sponsor
- Tongji Hospital
Advanced Biliary Tract Cancer(BTC), Advanced Pancreatic Cancers
A Prospective Observational Study of First-Line Systemic Therapy Combined With Celiac Plexus Blockade for Advanced Biliopancreatic Cancer With Pain
This study is for patients with advanced bile duct or pancreatic cancer who are experiencing pain from their disease. The purpose of this research is to learn about the effects of combining a standard pain relief treatment…
- Conditions
- Advanced Biliary Tract Cancer(BTC), Advanced Pancreatic Cancers, Cancer-related Pain
- Trial name
- NCT07326137
- Testing
- First-Line Systemic Therapy, Celiac Plexus Neurolysis (CPN)
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Tongji Hospital
Colorectal Cancer Liver Metastases (CRLM)
AI-Based Prediction of Liver Metastasis in Colorectal Cancer (A Retrospective Study)
This multicenter, retrospective study aims to develop and validate a multimodal deep learning model for predicting the risk of metachronous liver metastasis in patients with stage I-III colorectal cancer following curative…
- Trial name
- NCT07399236
- Testing
- Multimodal Deep Learning Model Analysis
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Tongji Hospital
Coronary Artery Disease, Myocardial Infarction
Foundation Model for Post-MI Cardiovascular Event Alert Using Huawei Watch
The goal of this randomized controlled trial is to evaluate whether a HUAWEI smartwatch integrated with a foundation model can enhance daily monitoring and management of AMI patients during outpatient cardiac rehabilitation after…
- Trial name
- NCT07395648
- Testing
- Smartwatch + AI assisted, Smartwatch only, Conventional care
- Volunteers
- 1,050 people
- Sponsor
- Tongji Hospital
Colorectal Cancer Liver Metastasis
Prospective Validation of an AI Model for Predicting Liver Metastasis in Colorectal Cancer
This is a prospective, multicenter, observational study designed to validate the predictive accuracy of a pre-developed multimodal deep learning model.
- Trial name
- NCT07392567
- Testing
- Multimodal Deep Learning Prediction Model
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tongji Hospital
R/R Grade 4 Glioma
TH-CAR-027 for Grade 4 Gliomas
This is an open-Label, dose-escalation, multiple administration, exploratory clinical study to evaluate the safety, tolerability, and anti-tumor activity of TH-CART-027 cell injection in subjects with recurrent or progressive…
- Trial name
- NCT07384390
- Testing
- TH-CART-027
- Volunteers
- 21 people
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Migraine
Desvenlafaxine for Preventive Treatment of Frequent Migraines
To evaluate whether Desvenlafaxine can reduce the frequency and severity of migraine attacks in patients.
- Trial name
- NCT07385755
- Testing
- Desvenlafaxine
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Tongji Hospital
HCC, Adjuvant Therapy
Adjuvant Anti-PD-1 Therapy in Resected Hepatocellular Carcinoma
Early hepatocellular carcinoma (HCC) recurrence (driven by residual tumors) and late recurrence (driven by de novo tumors) exhibit distinct biological behaviors, suggesting differential therapeutic vulnerabilities.
- Conditions
- HCC, Adjuvant Therapy, Recurrence, Immune Checkpoint Inhibitor
- Trial name
- NCT07379489
- Testing
- PD-1 Inhibitors
- Volunteers
- 300 people
- Sponsor
- Tongji Hospital
Myocardial Injury, Thoracic Diseases
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery
Myocardial injury after noncardiac surgery (MINS) refers to postoperative elevation of cardiac troponin (cTn) levels caused by underlying ischemic mechanisms (i.e., coronary artery supply-demand imbalance or atherosclerotic…
- Conditions
- Myocardial Injury, Thoracic Diseases, Thoracoscopic Surgery
- Trial name
- CP-MINS (NCT07028593)
- Testing
- Propofol, ciprofol
- Where
- China
- Volunteers
- 1,058 people
- Sponsor
- Tongji Hospital
Systemic Sclerosis
A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis
Systemic Sclerosis (Ssc) is a rare, systemic autoimmune disease characterized by skin fibrosis and vasculopathy. In addition to the skin, it is a heterogeneous disease that affects multiple organs, including the musculoskeletal…
- Trial name
- NCT05300932
- Testing
- Baricitinib, Cyclophosphamide
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Fiberoptic Bronchoscopy
Dexmedetomidine Nasal Spray and Pediatric Bronchoscopy
To observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy…
- Trial name
- NCT06755996
- Testing
- Dexmedetomidine injection, Remimazolam
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tongji Hospital
Lupus or SLE, Interstitial Lung Disease
Effects of Telitacicept vs Cyclophosphamide on Lupus Related Interstitial Lung Disease
Recent data indicate that Telitacicept is beneficial for lupus nephritis. Our goal is to determine whether Telitacicept is an effective and safe treatment, compared to standard-of-care Cyclophosphamide, for subclinical and…
- Conditions
- Lupus or SLE, Interstitial Lung Disease, Systemic Lupus Erythematosus
- Trial name
- NCT07077486
- Testing
- Methylprednisolone (Corticosteroid), Immunosuppressant other than CYC, Telitacicept Freeze-dried powder Injection 80mg
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Blau Syndrome
Effective Treatment of Jak1/3 Inhibitor in Blau Syndrome
To investigate the effectiveness of the JAK 1/3 inhibitor tofacitinib in treating Blau syndrome and explore the association between various clinical and genetic features and therapeutic responses within the cohort.
- Trial name
- inapplicable (NCT06688838)
- Testing
- Tofacitinib
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Tongji Hospital
Familial Mediterranean Fever (FMF )
Observing the Efficacy and Safety of Different Drugs Used in Real-world Familial Mediterranean Fever (FMF) Cases
retrospective observe the efficacy and safety of different drugs used in familial Mediterranean fever (FMF) cases in real-world
- Trial name
- NCT07077473
- Testing
- real word drugs
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Tongji Hospital
Ankylosing Spondylitis (AS)
A Study Evaluating the Efficacy of Secukinumab 300mg in Chinese Adults With Active Ankylosing Spondylitis
The purpose of this study is to evaluate the safety and efficacy of secukinumab 300mg in Chinese adults participants with active ankylosing spondylitis (AS) who have had an inadequate response to at least 2 non-steroidal…
- Trial name
- NCT05303285
- Testing
- Secukinumab 300mg s.c., Secukinumab 150mg s.c.
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Bladder Cancer (BC)
Safety, Tolerability, and Preliminary Efficacy of KD01 Via Intravesical Instillation in Bladder Cancer (BC)
Recombinant oncolytic adenovirus injection (KD01) is an oncolytic virus product. Its main component is a conditionally replicative recombinant human type 5 adenovirus, where part of the E3 region has been replaced with the gene…
- Trial name
- NCT07359235
- Testing
- KD01(the recombinant oncolytic adenovirus)
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Tongji Hospital
Tension Type Headache
Desvenlafaxine for Preventive Treatment of Frequent Episodic Tension-type Headache
To evaluate whether Desvenlafaxine can reduce the frequency and severity of TTH attacks in patients.
- Trial name
- NCT07359248
- Testing
- Desvenlafaxine
- Where
- China
- Volunteers
- 432 people
- Sponsor
- Tongji Hospital