Clinical trials: sponsored by Tongji Hospital
Autoimmune Diseases of the Nervous System
JY231 Injection for the Treatment of Relapsed/Refractory Neurologic Immune Disorders
his study is an investigator-initiated single center, single arm clinical study with a target population of patients with relapsed/refractory neurologic immune disorders.
- Trial name
- JY231 NID (NCT06797024)
- Testing
- JY231 Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tongji Hospital
Colorectal Liver Metastasis (CRLM)
FOLFOX-HAIC as Conversion Treatment for Initially Unresectable Colorectal Liver Metastasis
Try FOLFOX-HAIC combining bevacizumab or cetuximab for initially unresectable colorectal liver metastasis patients to increase the conversion to resection rate to improve long-term survival outcomes
- Trial name
- NCT06988852
- Testing
- FOLFOX (oxaliplatin, leucovorin, 5-fluorouracil [5FU]), hepatic arterial infusion chemotherapy (HAIC), Bevacizumab
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tongji Hospital
Ovarian Cancer
SHR - A1811 Versus Chemotherapy for Platinum-resistant Recurrent Epithelial Ovarian Cancer
This study is a randomized, open-label, active-controlled, multicenter phase III clinical trial. It is planned to enroll 300 subjects with platinum-resistant recurrent epithelial ovarian cancer, fallopian tube cancer, or primary…
- Trial name
- NCT06990503
- Testing
- SHR-A1811, Chemotherapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tongji Hospital
Ovarian Cancer
SHR - A1811 Injection in the Treatment of Platinum-sensitive Recurrent Ovarian Cancer
This study is a multi - center, single - arm, open - label, phase Ib/II clinical trial for dose exploration and efficacy expansion.
- Trial name
- NCT06990516
- Testing
- SHR-A1811, Carboplatin, Oxaliplatin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tongji Hospital
Non-Hodgkin's B-cell Lymphoma
A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects
The trial is a single arm, single-center, non-randomized phase I clinical trial which is designed to evaluate the safety and efficacy of C-CAR039 in treatment of relapsed or refractory NHL patients
- Trial name
- NCT04317885
- Testing
- Prizloncabtagene Autoleucel
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Neuroendocrine Tumors
Correlation Between Body Composition and Pathologic Grade/Prognosis in GEP-NENs: A Retrospective Study
The goal of this observational study is to learn about the value of body composition as predictors of pathological grading and prognosis in patients with gastroenteropancreatic neuroendocrine neoplasms.
- Trial name
- GEP-NENs (NCT06983106)
- Testing
- body composition calculate
- Where
- China
- Volunteers
- 633 people
- Sponsor
- Tongji Hospital
Coronary Stenosis, Cerebral Arterial Diseases
Wearable Devices Assist in the Detection, Screening, and Management of Major Diseases in Middle-aged and Elderly Populations
The goal of this randomized controlled trial is to evaluate the effectiveness of wearable devices (Huawei smartwatches) in aiding the detection, and screening of major diseases (e.g., coronary artery disease, hypertension) in…
- Conditions
- Coronary Stenosis, Cerebral Arterial Diseases, Hypertension, Parkinson Disease
- Trial name
- NCT06980064
- Testing
- Smartwatch + GP, GP only
- Volunteers
- 800 people
- Sponsor
- Tongji Hospital
Solid Tumors
An Exploratory Clinical Study of the Efficiency and Safety of TH027 in the Treatment of Relapsed/Refractory Solid Tumors
This is a Phase l, Open-Label, Dose-escalation Study to Evaluate the Safety, Tolerabilityand Antitumor Activity of TH027 CAR-T Cell lnjection (TH-CART-027) in Subjects With Relapsed or Refractory Solid Tumors.
- Trial name
- NCT06951425
- Testing
- TH-CART-027
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Encephalitis, Encephalitis, Viral
Efficacy and Safety of Calculus Bovis Sativus (CBS) for Adult Encephalitis (CBSinEncephalitis)
Based on the records of traditional Chinese medicine, CBS has the functions of purifying the heart, eliminating phlegm, stimulating bile secretion, and soothing the nerves.
- Conditions
- Encephalitis, Encephalitis, Viral, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis
- Trial name
- NCT06584045
- Testing
- Calculus bovis sativus (CBS)
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Central Nervous System Diseases
TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System
Central Nervous System (CNS) inflammation is an immune response activated in the brain and spinal cord by microglial cells and astrocytes, commonly occurring under conditions such as central nervous system ischemia, autoimmunity…
- Trial name
- NCT06467773
- Testing
- Radiation: PET-MRI with [18F]-DPA-714
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Myeloid Malignancies, CAR-T
Exploratory Clinical Study on the Safety and Efficacy of CAR-T Cell Therapy in the Treatment of Relapsed/Refractory Myeloid Malignancies
This is an open-label, single-arm, exploratory clinical trial utilizing a "3+3" dose escalation followed by dose expansion to evaluate the safety, maximum tolerated dose (MTD), pharmacokinetics (PK), and preliminary efficacy of…
- Trial name
- NCT06917105
- Testing
- CD33/CD123/CLL-1 CAR-T Cells
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Tongji Hospital
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
Equecabtagene Autoleucel Injection (Eque-cel) for Relapsed/Refractory Systemic Lupus Erythematosus (SLE)
This is a single-center, open-label, exploratory clinical study to evaluate the efficacy and safety of Equecabtagene Autoleucel Injection (Eque-cel) in patients with Relapsed /refractory systemic lupus erythematosus (SLE).
- Trial name
- NCT06902844
- Testing
- Equecabtagene Autoleucel Injection
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Tongji Hospital
Cervical Cancer, Locally Advanced Cervical Cancer
Neoadjuvant Immunochemotherapy in PD-L1-negative LACC
This is a multicenter, prospective, single-arm, phase 2 clinical trial designed to evaluate the therapeutic efficacy of the NACI (neoadjuvant chemotherapy plus Camrelizumab) for PD-L1-negative locally advanced cervical cancer.
- Conditions
- Cervical Cancer, Locally Advanced Cervical Cancer, PD-L1 Negative, Neoadjuvant Chemoimmunotherapy
- Trial name
- NCT06288360
- Testing
- Camrelizumab, Paclitaxel-albumin, Cisplatin
- Where
- 12 sites in China
- Volunteers
- 40 people
- Sponsor
- Tongji Hospital
Trigeminal Neuralgia (TN)
Magnetic Resonance Imaging in Patients with Trigeminal Neuralgia
This study intends to use MRI technology to analyze the dynamic changes and microstructure changes of the brain network in patients with trigeminal neuralgia, evaluate the blood-brain barrier and water exchange rate, and further…
- Trial name
- NCT06853119
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Intrahepatic Cholangiocarcinoma
A Clinical Study of DEB-TACE Combined With Surufatinib and Camrelizumab in the Treatment of Inoperable or Metastatic ICC
At present, for advanced Intrahepatic Cholangiocarcinoma（ICC）, the effect of single treatment is not good.So far, superselective drug-eluting bead transarterial chemoembolization（DEB-TACE） is a good method for the treatment of…
- Trial name
- CCGLC-005 (NCT05236699)
- Testing
- DEB-TACE combined with Surufatinib and Camrelizumab
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Tongji Hospital
Hepatocellular Carcinoma, Biliary Tract Cancer
Ambispective Cohort Study of Precision Medicine for Primary Hepatobiliary Cancer Based on Next-generation Sequencing
Exploring the precise medicine of patients with primary hepatobiliary cancer. And evaluate the efficacy and safety of individualized treatment regimens for primary hepatobiliary cancer based on next-generation sequencing.
- Trial name
- CCGLC-006 (NCT05520788)
- Testing
- precise medicine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital
Delirium, Post-operative Delirium
Nitric Oxide Levels Were Associated With Postoperative Delirium Following Cardiac Surgery
This study is a single-center prospective observational study conducted at the operating room, post-anesthesia care unit, and ICU of Tongji Hospital, from April 2023 to September 2024.
- Trial name
- NCT06748391
- Where
- China
- Volunteers
- 1,939 people
- Sponsor
- Tongji Hospital
Effect of Drug
Effect of Equivalent Dose of Alfentanil and Sufentanil in Bronchoscopic Treatment
The equivalent dose of sufentanil and afentanil combined with laryngeal mask was used for complex bronchoscopy to observe the intraoperative effect and the influence on the recovery of patients
- Trial name
- EOEDSAAIBT (NCT06414018)
- Testing
- Alfentanil
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tongji Hospital
Video-assisted Thoracoscopic Lung Surgery；Anesthesia
Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS
Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery.
- Trial name
- NCT06367218
- Testing
- opioid based strategy, opioid-free strategy, Laryngeal mask airway; Preserved spontaneous breathing
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Tongji Hospital
Postoperative Analgesia
Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study
Identifying the lowest effective opioid dose that achieves rapid pain relief while minimizing side effects is a principal objective in postoperative multimodal analgesia strategies.
- Trial name
- NCT06409689
- Testing
- Oliceridine fumarate low dose, Oliceridine fumarate high dose, Oliceridine fumarate moderate dose
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tongji Hospital