Clinical trials: sponsored by Turku University Hospital
Multiple Sclerosis
Sphingosine-1 Phosphate -Receptor Targeting and Microglial Activation
To evaluate the usability of positron emission tomography imaging as a novel outcome measure in multiple sclerosis studies
- Trial name
- FINGOPET (NCT02139696)
- Testing
- PET and MRI
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital
Hip Osteoarthritis
Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women
This randomized clinical trial will evaluate the efficacy of an antiresorptive osteoporosis drug (denosumab) in prevention of periprosthetic bone loss and in promotion of implant osseointegration (bone bonding) in postmenopausal…
- Trial name
- ProliaHip (NCT01926158)
- Testing
- Denosumb
- Where
- Finland
- Volunteers
- 65 people
- Sponsor
- Turku University Hospital
Premature; Infant, Light-for-dates, Breastfeeding
Probiotics and Early Microbial Contact in Preterm Neonates
Probiotics are live microbes which, when administered in sufficient amounts, confer a health benefit to the host. According to recent clinical trials, administration of probiotics to very low birth weight infants significantly…
- Trial name
- ProPre (NCT01454661)
- Testing
- LGG, LGG+Bb-12
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Prostate Cancer
Prostate Magnetic Resonance Imaging in Patient With Previous Negative Biopsies
Prostate cancer has been the most common neoplastic disease in men in Finland over the last ten years. Prostate-specific antigen (PSA) plays an important role in screening of prostate cancer.
- Trial name
- PROMANEG (NCT02388126)
- Testing
- 3T multiparametric MRI, Transrectal ultrasound
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Turku University Hospital
Bladder Cancer
PET/MRI and Biomarkers in Bladder Cancer
Muscle invasive bladder cancer is an aggressive malignancy. Currently the investigators lack accurate imaging technologies in clinical staging and estimation of response to neoadjuvant chemotherapy as well as prognostic…
- Trial name
- ACEBIB (NCT01918592)
- Testing
- MRI/acetate-PET imaging
- Where
- 3 sites in Finland
- Volunteers
- 25 people
- Sponsor
- Turku University Hospital
Prostate Cancer
MRI and Biomarkers in Prostate Cancer
Prostate cancer has been the most common neoplastic disease in men in Finland over the last ten years. Prostate-specific antigen (PSA) plays an important role in screening of prostate cancer.
- Trial name
- Multi-IMPROD (NCT02241122)
- Testing
- prostate biopsy
- Where
- 5 sites in Finland
- Volunteers
- 350 people
- Sponsor
- Turku University Hospital
Glaucoma, Mild Cognitive Impairment
Assessing Neurovisual Function in Patients With Cognitive Impairment
The aim of this study is to measure fitness to drive in patients with a visual and a cognitive impairment. To do so, Ocusweep is used in patients with glaucoma and Mild Cognitive Impairment.
- Conditions
- Glaucoma, Mild Cognitive Impairment, Glaucoma and Mild Cognitive Impairment, Healthy
- Trial name
- NCT03333096
- Testing
- Ocusweep test battery, Neuropsychological test battery
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Substance-Related Disorders, Pregnancy, High Risk
A Prenatal Mentalization-focused 4D Ultrasound and a Pregnancy Diary Intervention for Substance-abusing Women
Objective: This randomized and controlled trial was aimed at exploring the effect of a new mentalization-focused 4D interactive ultrasound and a week-by-week pregnancy diary intervention with substance-abusing pregnant women.
- Conditions
- Substance-Related Disorders, Pregnancy, High Risk, Prenatal Care, Maternal-Fetal Relations
- Trial name
- NCT03413631
- Testing
- Prenatal mentalization intervention, Prenatal obstetric treatment as usual
- Where
- Finland
- Volunteers
- 126 people
- Sponsor
- Turku University Hospital
Insulin Resistance
Effects of Intranasal Insulin Administration on Tissue Specific Insulin Sensitivity
Recent research has suggested that intranasally administered insulin can reach the brain quickly without passing through circulation and evoke increased insulin sensitivity and tissue glucose consumption during insulin…
- Trial name
- NASO-PET (NCT02933645)
- Testing
- Actrapid, [18F]-FDG PET-CT, Hyperinsulinemic euglycemic clamp
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity
Adenosine and A2A Receptors in Human Brown Adipose Tissue
This study investigates the significance of adenosine and A2A receptors in human brown adipose tissue (BAT) in vivo. Using positron emission tomography (PET), perfusion and the density of A2A receptors will be measured in…
- Trial name
- AdenoBAT (NCT03327168)
- Testing
- Adenosine, Cold exposure
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Prostate Cancer
The Effect of ADT on PSMA-PET.
Phase A: To describe and to determine the maximum standardised uptake values (SUV) in prostate specific membrane antigen positron emission tomography (PSMA-PET) before ADT and 7, 14 and 28 days after ADT.
- Trial name
- ADTPSMA (NCT03313726)
- Testing
- GnRH antagonist
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Pain
Bioavailability of Subcutaneous Dexmedetomidine
The aim of this study is to investigate the pharmacokinetics of subcutaneously administered dexmedetomidine in healthy volunteers. The absolute bioavailability of subcutaneously administered dexmedetomidine will be calculated.
- Trial name
- ScDex (NCT02724098)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Morbid Obesity
Laparoscopic Gastric Bypass Versus Sleeve Gastrectomy to Treat Morbid Obesity
Bariatric surgery in the treatment of morbid obesity is associated with long-term weight-loss and decreased overall mortality. Long-term results have been reported for laparoscopic gastric bypass procedures but the long-term…
- Trial name
- SLEEVEPASS (NCT00793143)
- Where
- 4 sites in Finland
- Volunteers
- 240 people
- Sponsor
- Turku University Hospital
Adverse Reactions to Metal Debris, Infection of Total Hip Joint Prosthesis
Imaging of Joint Replacement Complications by PET/CT
Total hip replacement is the well-established surgical method for treatment of hip osteoarthritis and related diseases. The outcome of the procedure is commonly satisfactory and most patients will not need any revision surgery.
- Conditions
- Adverse Reactions to Metal Debris, Infection of Total Hip Joint Prosthesis, Mechanical Loosening of Prosthetic Joint
- Trial name
- Propeli (NCT01970228)
- Testing
- 68Ga-citrate and 18F-FDG PET/CT imaging
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- Turku University Hospital
Macular Degeneration
Evaluation of Visual Function and Driving Health Using Ocusweep in Patients Suffering From Wet Age-related Macular Degeneration
The aim is to study the use of Ocusweep system especially in driving health evaluation and compare the results produced by Ocusweep system to those of conventional devices.
- Trial name
- NCT02747368
- Testing
- Ocusweep system
- Volunteers
- 600 people
- Sponsor
- Turku University Hospital
Bone Metastases, Bone Neoplasm
MR Imaging- Guided High Intensity Focused Ultrasound (HIFU) Therapy of Bone Metastases
Bone metastasis give rise to major complications that lead to significant morbidity and impairment of life quality. The most common primary for bone metastasis is prostate, lung and breast carcinoma.
- Conditions
- Bone Metastases, Bone Neoplasm, Bone Cancer, Bone Lesion
- Trial name
- NCT03106675
- Testing
- Thermal ablation of bone metastasis with MR-HIFU device Philips Sonalleve coupled with Philips Ingenia 3.0T, Varian Truebeam Radiotherapy System
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Morbid Obesity
Prospective, Randomised Study: Metabolic and Functional Effects of Bariatric Surgery Accessed Using PET and MRI.
The objectives of this study are to measure effect of obesity on brain structure and molecular pathways, food-stimuli mediated brain activation response, on hormones affecting both feeding and energy balance as well as on bone…
- Trial name
- Sleevepet2 (NCT01373892)
- Testing
- Bariatric surgery
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Hip Osteoarthritis
Efficacy of Zoledronic Acid in Enhancement of Early Stability of Cementless Primary Hip Prosthesis
This is a randomized, double-blind and placebo-controlled study to evaluate the efficacy of zoledronic acid on the biologic incorporation of cementless hip prosthesis in postmenopausal female patients.The study population…
- Trial name
- NCT01218035
- Testing
- zoledronic acid
- Where
- Finland
- Volunteers
- 49 people
- Sponsor
- Turku University Hospital
Subarachnoid Hemorrhage, Aneurysm
Dexmedetomidine and Subarachnoid Haemorrhage
The purpose of this study is to investigate how dexmedetomidine affects static and dynamic autoregulation, intracranial pressure (ICP) and cerebral oxygenation in aneurysmal subarachnoid haemorrhage (SAH) patients.
- Trial name
- NCT01664520
- Testing
- Dexmedetomidine infusion
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital
Infertility
GnRH Agonist as Luteal Support in FET Cycles
Back ground: A single dose of GnRH analogue in the luteal phase is reported to improve the outcome of IVF/ICSI treatments but the effect in FET cycles has not been reported.
- Trial name
- NCT02620124
- Testing
- Natural cycle: Triptorelin acetate 0.1 mg, Hormone replacement cycle and triptorelin acetate 0.1 mg
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital