Clinical trials: sponsored by Turku University Hospital
Scoliosis, Spondylolisthesis
Effect of Pregabalin on Immediate Post-operative and Longterm Pain
This study aims to evaluate the incidence of longterm pain after spinal fusion surgery in children and adolescents. In the second part of the study a randomized double-blind clinical trial will be conducted.
- Trial name
- NCT02464813
- Testing
- Pregabalin, Sugar pill, Oxycodone
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Turku University Hospital
Osteoarthritis, Knee
Finnish Unicompartmental and Total Knee Arthroplasty Investigation
Unicondylar knee arthroplasty (UKA) can be used as the treatment of knee OA isolated to a single compartment instead of TKA. Both UKA and TKA have been used for decades as a treatment of knee OA.
- Trial name
- FUNCTION (NCT02481427)
- Testing
- Unicondylar Knee Replacement, Total Knee Replacement
- Where
- 3 sites in Finland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Adolescent Idiopathic Scoliosis
Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery
The Finnish Paediatric Orthopaedic Study Group will perform a prospective randomized, multicenter, clinical trial comparing Gelatin matrix with human derived thrombin (Floseal, Baxter) and without use of Floseal in adolescents…
- Trial name
- NCT01451788
- Testing
- Gelatin matrix with human derived thrombin (Floseal, Baxter)
- Where
- 3 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Cancer, Breast
Exercise and Tumor Blood Flow in Breast Cancer Patients
This research aims at investigating tumor blood flow response to acute exercise in human cancer patients. It is hypothesized and expected that acute exercise increases tumor blood flow, which could plausibly increase the efficacy…
- Trial name
- EXETUMOR2 (NCT04416087)
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Back Pain, Stress Fracture
Posterior Lumbar Stress Reaction in Pediatric Patients. Treatment With or Without Soft Spinal Brace?
A clinical trial will be conducted comparing healing of a posterior lumbar vertebra stress reaction in children treated either with cessation of sports activities for a period of six weeks and wearing a soft spinal brace 16 hours…
- Trial name
- NCT04533178
- Testing
- soft spinal brace, Resting from all sports activities
- Where
- 4 sites in Finland
- Volunteers
- 110 people
- Sponsor
- Turku University Hospital
Bladder Cancer
MRI in Clinical Staging and Estimation of Treatment Response in Bladder Cancer
Bladder cancer (BC) as the most common malignancy arising from the urinary tract continues to be a major health problem. This prospective non-randomized study will enroll 150 patients undergoing magnetic resonance imaging (MRI)…
- Trial name
- MIB (NCT02662166)
- Testing
- MR imaging
- Where
- 2 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
Prolonged Pregnancy, Sleep Disturbance
Sleep and Depression in Induction of Labour
Randomised trial comparing double balloon catheter for induction of labor between inpatient and outpatient groups. The investigators assess how sleep disturbances and depression of the mother affect to the pain during balloon…
- Conditions
- Prolonged Pregnancy, Sleep Disturbance, Depression
- Trial name
- NCT03380897
- Testing
- Intervention for outpatient group was to go home, Intervention for inpatient group was to stay at ward
- Where
- Finland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Prolonged Pregnancy
Outpatient Versus Inpatient Balloon Catheter Induction of Labor
Randomized trial comparing double balloon catheter for induction of labor between in- and outpatient groups.Investigators assess feasibility, clinical effectiveness and patient acceptability of outpatient versus inpatient…
- Trial name
- NCT02793609
- Testing
- Intervention is to let patient to go home., Intervention is to observe women in the ward.
- Where
- Finland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Chronic Kidney Disease
Chronic Kidney Disease and Bone - Correlation Between 18F-PET-TT Imaging and Histomorphometry of Bone in CKD Patients
Chronic kidney disease (CKD) is an increasing public health problem and the number of patient with chronic kidney disease is increasing worldwide.
- Trial name
- CKD-Bone (NCT02967042)
- Testing
- 18F-PET-TT
- Where
- Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Tennis Elbow, Lateral Epicondylitis
Levobupivacaine Versus Liposomal Bupivacaine (Exparel®) for Treatment of Pain and Disability in Lateral Epicondylitis
The main objective of the trial is to compare the effectiveness of injected levobupivacaine and liposomal bupivacaine in the treatment of pain and disability in patients with lateral epicondylitis.
- Trial name
- LELIBU (NCT04382144)
- Testing
- Liposomal bupivacaine
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
Metabolic Syndrome, Physical Activity
Medical and Physiological Benefits of Reduced Sitting
The most important objective of this randomized controlled trial in subjects with increased cardiovascular and metabolic risk factors is to investigate whether only reduced daily sitting improves human cardiovascular and…
- Conditions
- Metabolic Syndrome, Physical Activity, Insulin Resistance, Cardiovascular Diseases
- Trial name
- NCT03101228
- Testing
- Reduced sitting
- Where
- Finland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Carpal Tunnel Syndrome
Scalpel Versus Electrocautery for Surgical Skin Incision in Open Carpal Tunnel Release
The use of electrocautery for surgical skin incision in general surgery is known to decrease post-operative pain. This study compares the use of scalpel and electrocautery for surgical skin incision in open carpal tunnel release…
- Trial name
- OCTR-Electro (NCT02791529)
- Testing
- Electrocautery, Scalpel
- Volunteers
- 16 people
- Sponsor
- Turku University Hospital
Acute Heart Failure, Low Output Heart Failure
Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation
Cardiac surgery can be not infrequently complicated by cardiac low-output syndrome due to critical preoperative conditions such as cardiogenic shock, poor left ventricular function and severe myocardial ischemia.
- Conditions
- Acute Heart Failure, Low Output Heart Failure, Cardiac Output, Low, Extracorporeal Membrane Oxygenation
- Trial name
- PC-ECMO (NCT03508505)
- Testing
- Venoarterial extracorporeal oxygenation
- Where
- Finland
- Volunteers
- 1,000 people
- Sponsor
- Turku University Hospital
Aortic Valve Stenosis
Finnish Registry of Transcatheter and Surgical Aortic Valve Replacement for Aortic Valve Stenosis: FinnValve Registry
The FinnValve investigators planned a nationwide registry to investigate the early and late outcome of transcatheter aortic valve implantation (TAVI) compared to surgical aortic valve replacement (SAVR) in patients with aortic…
- Trial name
- FinnValve (NCT03385915)
- Testing
- Aortic valve replacement
- Where
- Finland
- Volunteers
- 6,463 people
- Sponsor
- Turku University Hospital
Urinary Incontinence,Stress, Urinary Incontinence, Urge
Tension-free Vaginal Tape Obturator for the Treatment of Urinary Incontinence -Long-term Follow-up
The efficacy of TVT-O (tension-free vaginal tape obturator) is well established in patients with stress urinary incontinence (SUI).
- Trial name
- NCT04240613
- Testing
- TVT-O
- Volunteers
- 106 people
- Sponsor
- Turku University Hospital
Obesity
Secretin Activates Human Brown Fat and Induces Satiation.
15 healthy males will be studied with PET/CT, using FDG to investigate glucose metabolism, and radiowater to investigate perfusion.
- Trial name
- GUTBAT (NCT03290846)
- Testing
- Secretin Human, Saline Solution, Cold exposure
- Where
- Finland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cancer
Active Video Games to Promote Physical Activity in Children With Cancer
The aim of this study is to evaluate the efficacy and feasibility of active video gaming with regard to the promotion of physical activity and motor learning in children with cancer.
- Trial name
- NCT01748058
- Testing
- Exercise based on active video gaming
- Where
- Finland
- Volunteers
- 36 people
- Sponsor
- Turku University Hospital
Pain, Postoperative
Dose-response of Ketamine in Patient Controlled Analgesia in Orthopaedic Surgery Patients
To study the multimodal protocol combining adjunct ketamine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral…
- Trial name
- DoseRespKeta (NCT02994173)
- Testing
- Oxycodone, S-Ketamine 0.25, S-Ketamine 0.5
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Alzheimer Disease, Dementia
Processing of Music in Alzheimer Patients
Correlation of musicality, brain atrophy in brain areas relevant for music processing and the stage of Alzheimer´s disease.
- Conditions
- Alzheimer Disease, Dementia, Amusia
- Trial name
- MUKU-DEM (NCT04132193)
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
Squamous Cell Carcinoma of the Head and Neck
Reproducibility of Intratumor Distribution of 18F-EF5 in Head and Neck Cancer
The results of previous studies suggest further development of [18F]EF5 as a PET tracer for imaging hypoxia. This is a non-randomized prospective study to obtain information on reproducibility of [18F]EF5 intratumor distribution…
- Trial name
- NCT01774760
- Testing
- 18F-EF5, Pretreatment PET/CT-scan (performed two times)
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital