Clinical trials: sponsored by UMC Utrecht
Cardiovascular Health, Metabolic Health
Children Follow-up of PCOS Women
Polycystic ovary syndrome (PCOS) is a complex and frequent disorder with a heterogeneous clinical presentation varying throughout life, from birth up to post-menopause.
- Conditions
- Cardiovascular Health, Metabolic Health, Pulmonary Health
- Trial name
- CHOPS (NCT01767051)
- Where
- Netherlands
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Trauma, Inflammation
Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Trauma and major operation are associated with an excessive inflammation reaction due to tissue injury. This overwhelming immune response is considered to be a major risk factor in the pathogenesis of late inflammatory…
- Conditions
- Trauma, Inflammation, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- CAESAR (NCT01275976)
- Testing
- C1-esterase inhibitor, Saline 0.9%
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- UMC Utrecht
Pancreatic Cancer
Cone-beam CT Guided Stereotactic Radiation Therapy for Locally Advanced Pancreatic Cancer
Pancreatic cancer has a very poor survival, due to late diagnosis and lack of sufficient treatment options for locally advanced tumors and metastasized patients.
- Trial name
- NCT01898741
- Testing
- 24 Gy in 3 fractions
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Stage III Non-small Cell Lung Cancer
MRI Optimization Study in Stage III NSCLC
Radiation therapy uses radiation to treat lung tumors and metastases in the mediastinum. In order to irradiate as precise as possible, and in order to evaluate the effect of radiation treatment, it is important to depict the lung…
- Trial name
- NCT02076282
- Testing
- 1 MRI scan
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Locally Advanced Pancreatic Cancer
Safety Study of Radiofrequency Ablation of Locally Advanced Pancreatic Cancer
The purpose of the study is to determine the safety of radiofrequency ablation of locally advanced pancreatic cancer that can not be surgically removed with the current standard procedures.
- Trial name
- RFA of LAPC (NCT01628458)
- Testing
- radiofrequency ablation (RFA)
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- UMC Utrecht
Psychotic Disorders, Antisocial Personality Disorder
Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order
In a double blind randomized clinical trial with cross-over design, treatment using naratriptan will be compared to placebo within a group of 30 convicts with psychiatric disorders such as psychosis or psychopathy with repeated…
- Conditions
- Psychotic Disorders, Antisocial Personality Disorder, Impulse Regulation Disorder, Intermittent Explosive Disorder
- Trial name
- NCT00282165
- Testing
- naratriptan
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- UMC Utrecht
Insulin Resistance, Blood Pressure
Denervation of the REnal Artery in Metabolic Syndrome
The current prevalence of hypertension as part of the metabolic syndrome is substantial and is increasing with the rise of obesity worldwide.
- Trial name
- DREAMS (NCT01465724)
- Testing
- Renal denervation
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- UMC Utrecht
Cervical Cancer
The Value of Preoperative Sentinel Lymph Node Mapping by Pelvic MR Lymphangiography and SPECT-CT in Cervical Cancer
Objective of the study: To study the concordance of sentinel node (SN) localization between preoperative Magnetic Resonance Lymphangiography and SPECT-CT SN mapping and the intra-operative SN procedure for low stage cervical…
- Trial name
- NCT01777230
- Testing
- SPECT-CT sentinel node mapping, Magnetic Resonance Lymphangiography sentinel node mapping, Intra-operative sentinel node procedure
- Where
- Netherlands
- Sponsor
- UMC Utrecht
Myocardium; Injury, Coronary Artery Disease
Minimal Invasive Imaging of Coronary Artery Disease in Patients With Asymptomatic Myocardial Injury After Major Non-cardiac Surgery.
This is a cross-sectional pilot study to assess coronary artery disease with minimal invasive techniques in patients with asymptomatic troponin elevation after noncardiac surgery.
- Trial name
- AMI-NCS (NCT01960309)
- Testing
- Minimal invasive cardiac imaging
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- UMC Utrecht
Infertility
Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos
Human embryos can be preserved for later transfers by freezing. Traditionally the slow cooling method has been used. About 70% of the embryos remain fully intact after thawing.
- Trial name
- NCT00886431
- Testing
- embryo vitrification
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Schizophrenia, Psychotic Disorders
Theta Burst Transcranial Magnetic Stimulation as Treatment for Auditory Verbal Hallucinations
Auditory verbal hallucinations (AVH) are a characterising symptom of schizophrenia. In the majority of patients, these AVH respond well to antipsychotic medication.
- Trial name
- NCT01512290
- Testing
- Theta Burst Transcranial Magnetic Stimulation
- Where
- Netherlands
- Volunteers
- 71 people
- Sponsor
- UMC Utrecht
Type 2 Diabetes, Acute Coronary Event
Tailored Support for Type 2 Diabetes Patients With an Acute Coronary Event After Discharge From Hospital
Background: In type 2 diabetes mellitus patients, an acute coronary event (ACE) may result in a decreased quality of life and increased distress.
- Trial name
- Diacourse (NCT01801631)
- Testing
- Home visits, Consultation by telephone
- Where
- 13 sites in Netherlands
- Volunteers
- 201 people
- Sponsor
- UMC Utrecht
Heart Failure, Chronic Obstructive Pulmonary Disease
Triage of Reduced Exercise Tolerance in Frail Elderly
Background of the study: Many elderly suffer from reduced exercise tolerance or exercise induced shortness of breath (dyspnoea) which causes decreased mobility and restrictions in physical, psychological and social functioning.
- Trial name
- TREE (NCT01148719)
- Testing
- Index group
- Where
- Netherlands
- Volunteers
- 841 people
- Sponsor
- UMC Utrecht
Upper Respiratory Tract Infections, URTI
Innate Immune Response to (An)Aerobic Exercise in Rowing Athletes
Exercise induces innate immune response activation in athletes. The response starts during exercise and lasts for approximately 24 hours.
- Trial name
- INCREASE (NCT01893762)
- Testing
- Aerobic exercise, Anaerobic exercise
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Community-acquired Pneumonia
Community-Acquired Pneumonia - Study on the Initial Treatment With Antibiotics of Lower Respiratory Tract Infections
The purpose of this study is to compare the cost(effectiveness) of three existing antibiotic strategies for patients with community-acquired pneumonia admitted to the hospital, but not the ICU.
- Trial name
- CAP-START (NCT01660204)
- Testing
- Preferred empirical treatment
- Where
- 7 sites in Netherlands
- Volunteers
- 2,283 people
- Sponsor
- UMC Utrecht
Type 1 Diabetes Mellitus
Ovarian Ageing in Type 1 Diabetes Mellitus
In healthy women, early menopause is an event that is associated with the exacerbation of several risk factors of cardiovascular and skeletal disease.
- Trial name
- OVADIA (NCT01665716)
- Where
- Netherlands
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Atrial Fibrillation, Cardiac Surgery
Postoperative New-onset Atrial Fibrillation in Cardiac Surgery: DECS-PNAF Project
The DExamethasone for Cardiac Surgery - Postoperative New-onset Atrial Fibrillation (DECS-PNAF) project described in this protocol aims to elucidate how corticosteroids protect cardiac surgical patients from Postoperative…
- Trial name
- DECS-PNAF (NCT01143129)
- Testing
- Dexamethasone
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Incontinence
Comparison of Air Charged Catheters With Water Filled Catheters for Urodynamic Study
Various systems to measure intravesical and intrarectal pressure during urodynamic testing; especially cystometry, exist. Water filled tube -systems are the most commonly used and should be regarded as the contemporary standard.
- Trial name
- ACWF (NCT02030340)
- Testing
- lower urinary tract dysfunction
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- UMC Utrecht
HIV Infection, Endothelial Dysfunction
RAltegravir Switch STudy: Effects on Endothelial Recovery
Treatment with HIV-infection with protease inhibitors is associated with high blood lipids and higher chance for cardiovascular complications.
- Trial name
- RASSTER (NCT01453933)
- Testing
- raltegravir
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Stroke
The SMART-ORACLE Study
After having had a first cardiovascular event, there is a considerable risk of developing a subsequent event. Only recently, a risk prediction model was developed for this group of patients.
- Conditions
- Coronary Artery Disease, Stroke, Peripheral Arterial Disease, Hypertension
- Trial name
- SMART-ORACLE (NCT01932671)
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- UMC Utrecht