Clinical trials: sponsored by UMC Utrecht
IBD, Crohn Disease
The Nori Health App
A multicenter, randomized controlled trial with an embedded pilot and qualitative component to investigate the effects of the Nori Health app.
- Conditions
- IBD, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT05474742
- Testing
- The Nori Health app
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
PAIS, Neonatal Stroke
Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration
The aim of the study is to perform a randomized double-blind placebo controlled prospective study in newborn infants with MRI confirmed Middle Cerebral Artery (MCA) Perinatal Arterial Ischemic Stroke (PAIS) with darbepoetin.
- Conditions
- PAIS, Neonatal Stroke, Perinatal Stroke
- Trial name
- DINOSAUR (NCT03171818)
- Testing
- Darbepoetin Alfa, Saline
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Knee Pathology, Osteoarthritis, Knee
Knee Registry (Knieregister)
Rationale: In view of patient care, patient characteristics and treatment parameters are registered for all patients visiting the Mobility Clinic of the University Medical Center Utrecht for orthopaedic knee treatment.
- Conditions
- Knee Pathology, Osteoarthritis, Knee, Osteochondritis Dissecans, Chondral Defect
- Trial name
- NCT04364334
- Where
- Netherlands
- Volunteers
- 1,000,000 people
- Sponsor
- UMC Utrecht
Endometrial Cancer
Feasibility of Gallium-68-tilmanocept PET/CT for Sentinel Lymph Node Detection in Endometrial Cancer
This pilot study evaluates the feasibility of 68Ga-tilmanocept PET/CT for SLN mapping in patients with endometrial cancer.
- Trial name
- SENGA (NCT05446324)
- Testing
- Gallium-68-tilmanocept
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Surgery, Angiotensin Hypertension
Management of Angiotensin Inhibitors During the Perioperative Period
This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the perioperative period on…
- Conditions
- Surgery, Angiotensin Hypertension, Perioperative Complication
- Trial name
- AIPOP (NCT04506372)
- Testing
- Perioperative withdrawal of angiotensin converting enzyme inhibitors and angiotenin receptor blockers, Blood draw, Diary to register drug adherence
- Where
- 7 sites in Canada, Netherlands
- Volunteers
- 342 people
- Sponsor
- UMC Utrecht
Atopic Dermatitis
Identifying Atopic Dermatitis Patients at Risk for Developing Conjunctivitis During Dupilumab Treatment
Study on ophthalmological comorbidities and the underlying pathomechanisms of conjunctivitis during dupilumab treatment in atopic dermatitis (AD) patients. Patients participate in the Bioday Registry.
- Trial name
- NCT04276623
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Perioperative Complication, Infections
Perioperative Longitudinal Study of Complications and Long-term Outcomes
Purpose: with an increased risk of complications. Improved preoperative risk stratification and earlier diagnosis of these complications may ameliorate postoperative recovery and improve long-term outcomes.
- Conditions
- Perioperative Complication, Infections, Myocardium; Injury, Kidney Injury
- Trial name
- PLUTO (NCT05331118)
- Where
- Netherlands
- Volunteers
- 9,000 people
- Sponsor
- UMC Utrecht
Hospital-acquired Pneumonia, Ventilator Associated Pneumonia
HOspital NEtwork STudy - Preparation for a Randomized Evaluation of Anti-Pneumonia Strategies
Hospital Acquired and Ventilator Associated Pneumonia (HAP/VAP) pose a significant burden to patients admitted to the Intensive Care Unit (ICU).
- Trial name
- HONEST-PREPS (NCT05060718)
- Where
- 16 sites in Albania, Croatia and 5 more
- Volunteers
- 2,165 people
- Sponsor
- UMC Utrecht
Knee Osteoarthritis
Grip on Knee Osteoarthritis; DIstraction Versus Arthroplasty
The goal of this pragmatic, open, (1:1) randomized, multi-centre, non-inferiority trial is to to determine whether knee-joint distraction (KD) is non-inferior on patient reported effectiveness as compared to a knee-prosthesis…
- Trial name
- GODIVA (NCT06113549)
- Testing
- Knee Joint Distraction (KD), Knee Prosthesis
- Volunteers
- 600 people
- Sponsor
- UMC Utrecht
Pancreatic Cancer, Pancreatic Cyst
Improving Pancreatic Cancer Care by the Use of Computational Science and Technology
The goal of the IMPACT project is to set up a data sharing infrastructure between expert centers for pancreatic surgery that enables training, testing and validation of computer science tools to improve quality of care for…
- Conditions
- Pancreatic Cancer, Pancreatic Cyst, Pancreatic Adenocarcinoma, Pancreatic Diseases
- Trial name
- IMPACT (NCT06055010)
- Testing
- No interventions
- Where
- Netherlands
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Liver Cancer
Interventional X-ray and Scintigraphy Imaging of 99mTc-MAA During the Radioembolisation Pretreatment Procedure
To establish the safety and feasibility of interventional x-ray and scintigraphy imaging during the pre-treatment procedure of hepatic radioembolization
- Trial name
- IXSI (NCT06013774)
- Testing
- IXSI
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Cervical Cancer, Gynecologic Cancer
MRLinac Boost for Gynecological Cancers if Brachytherapy is Not Feasible (MARGARITA)
The goal of this observational study is to explore the effectiveness and side effects of a high dose daily adapted SBRT (stereotactic body radiotherapy) boost delivered with MRLinac in patients with gynaecological cancers that…
- Trial name
- MARGARITA (NCT05937958)
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Adolescent Idiopathic Scoliosis, 22q11.2 Deletion Syndrome
Early Scoliotic Changes in Children at Increased Risk for Scoliosis Development
Rationale: Despite several decades of research, the exact etiology of adolescent idiopathic scoliosis (AIS) remains unclear. In AIS, spine curvature begins with and progresses during the adolescent growth spurt.
- Trial name
- EARLYBIRD (NCT05924347)
- Testing
- MRI, Scolioscan, Skeletal maturity assessment
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Neuromuscular Scoliosis, Distraction System
Limited-efficacy Testing of SDS and NEMOST for Early Onset Neuromuscular Scoliosis
The primary aim of this study is to investigate and describe the limited efficacy of the Spring Distraction System (SDS) and Bilateral One Way Rod (NEMOST) in maintaining curve reduction without repeat lengthening procedures and…
- Conditions
- Neuromuscular Scoliosis, Distraction System, Growth Friendly System
- Trial name
- BiPOWR (NCT04021784)
- Testing
- SDS, NEMOST
- Where
- 3 sites in Netherlands
- Volunteers
- 28 people
- Sponsor
- UMC Utrecht
Cataract
Cataract Online Refraction Evaluation: A Multi Center Randomized Controlled Trial
Background of the study: Cataract is widely prevalent in especially elderly and cataract extraction surgery has thus become one of the most performedsurgeries worldwide.
- Trial name
- CORE-RCT (NCT04809402)
- Testing
- remote monitoring after cataract surgery
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 94 people
- Sponsor
- UMC Utrecht
Spinal Neoplasms, Neoplasm Metastasis
Stereotactic Body Radiotherapy Followed by Surgical Stabilization in Spinal Metastases
The aim of this study is to assess pain response after combining stereotactic body radiotherapy (SBRT) and pedicle screw fixation in a 48-hour window for the treatment of painful unstable metastases of the thoracic and/or lumbar…
- Conditions
- Spinal Neoplasms, Neoplasm Metastasis, Radiosurgery, Surgery
- Trial name
- BLEND-II (NCT05060653)
- Testing
- SBRT followed by surgical stabilization within 24-48 hours
- Where
- Netherlands
- Sponsor
- UMC Utrecht
COVID-19, SARS-CoV 2
EuRopean Study of MAjor Infectious Disease Syndromes Related to COVID-19
Background Rapid European COVID-19 Emergency Research response (RECoVER), is a project involving 10 international partners that has been selected for funding by the European Union under the Horizon 2020 research framework…
- Trial name
- MERMAIDS 2 (NCT04364711)
- Where
- 11 sites in Estonia, Greece and 6 more
- Volunteers
- 300 people
- Sponsor
- UMC Utrecht
Buccal Mucosa Cancer, Squamous Cell Carcinoma
Buccal Cancer Resection Ultrasound Guided
The aim of this research is to decrease the number of inadequate tumor-free margins, probably resulting in less adjuvant therapy, less local recurrences and better quality of life.
- Trial name
- BRUG (NCT05852665)
- Testing
- Ultrasound-guided resection
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Pseudoxanthoma Elasticum
The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum
The goal of this randomized clinical trial is to assess the effect of etidronate on ectopic calcification in relatively young patients with Pseudoxanthoma elasticum.
- Trial name
- TEMP-PREVENT (NCT05832580)
- Testing
- Etidronate
- Where
- Netherlands
- Volunteers
- 76 people
- Sponsor
- UMC Utrecht
Extracranial Carotid Artery Aneurysm
ECAA Brain MRI: Seeking the Link Between Extracranial Carotid Artery Aneurysms and Small Vessel Disease
In order to understand which ECAA patients benefit from medical therapy, more should be known about the possible outcomes of this rare disease.
- Trial name
- NCT05828576
- Testing
- MRI
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht