Clinical trials: sponsored by UMC Utrecht
Esophageal Cancer, Esophageal Adenocarcinoma
Preoperative Image-guided Identification of Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer
Rationale: For locally advanced esophageal cancer the standard treatment consists of 5 weeks of neoadjuvant chemoradiotherapy (nCRT) followed by surgery.
- Conditions
- Esophageal Cancer, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms
- Trial name
- PRIDE (NCT03474341)
- Testing
- MRI, PET-CT, Endoscopy
- Where
- 4 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
COVID-19; Cardiovascular Diseases
Cardiac complicAtions in Patients With SARS Corona vIrus 2 (COVID-19) regisTrY
CAPACITY (www.capacity-covid.eu) is a registry of patients with COVID-19 across Europe and has been established to answer questions on the role of cardiovascular disease in this pandemic.
- Trial name
- CAPACITY-COVID (NCT04325412)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Refractory Localization-related Epilepsy
A New Method for Delineation of Epileptic Brian Tissue During Epilepsy Surgery (The HFO Study)
Epilepsy occurs in 0.5-0.7% of the population, of which 25% are children. 30% Of patients with focal epilepsy do not respond well to medication and half of them are eligible for epilepsy surgery.
- Trial name
- NCT02207673
- Testing
- Tailoring of the resection based on biomarker in aEcoG during epilepsy surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Hodgkin's Lymphoma
Whole-body MRI in Pediatric Hodgkin's Lymphoma
Background: The assessment of extent of disease (staging) and response to therapy (restaging) is performed with computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET scan) or integrated…
- Trial name
- NCT04005703
- Where
- 8 sites in Austria, Italy and 2 more
- Volunteers
- 75 people
- Sponsor
- UMC Utrecht
Schizophrenia
European Long-acting Antipsychotics in Schizophrenia Trial
Schizophrenia is a chronic psychiatric illness with periods of remission and relapse. Patients vary in the frequency and severity of relapse, time until relapse and time in remission.
- Trial name
- EULAST (NCT02146547)
- Testing
- Aripiprazole, Aripiprazole depot, Paliperidone
- Where
- 49 sites in Austria, Belgium and 14 more
- Volunteers
- 536 people
- Sponsor
- UMC Utrecht
COVID-19
Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19
Rationale: Currently there are no approved treatments for COVID-19. In the Dutch treatment protocol guideline (SWAB) designated treatment is supportive care with the option to add chloroquine base (CQ) or hydroxychloroquine…
- Trial name
- ARCHAIC (NCT04362332)
- Testing
- Chloroquine Sulfate, Hydroxychloroquine, Standard supportive care
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Neuroendocrine Tumors
Holmium-166-radioembolization in NET After Lutetium-177-dotatate; an Efficacy Study
Patients with gastroenteropancreatic neuroendocrine tumours (NET) often die from intrahepatic disease or are excluded from liver-directed treatment because of extrahepatic disease.
- Trial name
- HEPAR_Plus (NCT02067988)
- Testing
- Holmium-166 microspheres hepatic radioembolization.
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- UMC Utrecht
Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Chest CT With Iterative Reconstruction as an Alternative to Conventional Chest X-ray Prior to Heart Surgery
To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared to…
- Conditions
- Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Stroke
- Trial name
- CRICKET (NCT02173470)
- Testing
- CT scan
- Where
- 3 sites in Hungary, Netherlands
- Volunteers
- 866 people
- Sponsor
- UMC Utrecht
Prostate Cancer, Radiotherapy
FLAME: Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer
Rationale: Dose escalation in external-beam irradiation has proven to benefit outcome in local prostate cancer. Randomized trials were performed up to doses of 78 Gy in 2 Gy fractions.
- Conditions
- Prostate Cancer, Radiotherapy, MRI
- Trial name
- FLAME (NCT01168479)
- Testing
- FLAME boost, standard arm
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 571 people
- Sponsor
- UMC Utrecht
Schizophrenia
Endocannabinoid Control of Microglia Activation as a New Therapeutic Target in the Treatment of Schizophrenia
The main objective of this study is to compare microglia activation as measured with proton Magnetic Resonance Spectroscopy (1H-MRS) between recent-onset schizophrenia patients who are randomised to CBD and those randomised to…
- Trial name
- CANGLIA (NCT02932605)
- Testing
- Cannabidiol
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- UMC Utrecht
Esophageal Carcinoma, Esophageal Cancer
Robot-assisted Thoraco-laparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy
This is the first randomized controlled trial designed to compare robot-assisted minimally invasive thoraco-laparoscopic esophagectomy with open transthoracic esophagectomy as surgical treatment for resectable esophageal cancer.
- Trial name
- ROBOT (NCT01544790)
- Testing
- Esophagectomy
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- UMC Utrecht
Early-Onset Scoliosis Deformity of Spine (Disorder), Idiopathic Scoliosis
Limited-efficacy Testing of Spring Distraction System (SDS) and Unilateral One-way Rod (MID-C) for Early Onset Scoliosis
The primary aim of this study is to investigate the limited efficacy of these innovative surgical solutions in treatment of Early Onset Scoliosis (EOS) in terms of maintaining reduction while maintaining spinal growth.
- Trial name
- UniPOWR (NCT04003233)
- Testing
- SDS, MID-C
- Where
- 2 sites in Netherlands
- Sponsor
- UMC Utrecht
Epileptic Seizure, Epilepsy Intractable
REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex.
People with central lobe epilepsy (CLE), with seizures arising from the primary sensorimotor cortex, typically show a high rate of convulsive seizures that do not respond to anti-epileptic drugs, but have a large impact on…
- Conditions
- Epileptic Seizure, Epilepsy Intractable, Motor Seizure
- Trial name
- REC2Stim (NCT04158531)
- Testing
- ECoG sensing and stimulation
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Infection Resistant to Drugs, Gram-Negative Bacterial Infection
Burden of Antibiotic Resistance in Gram-Negative Infections in Dutch Hospitals
This study aims to assess how large an additional disease burden and what extra costs are generated by antibiotic resistance in patients suffering from infections caused by gram-negative bacteria, such as Escherichia coli and…
- Trial name
- GRAND-ABC (NCT02007343)
- Where
- 8 sites in Netherlands
- Volunteers
- 3,895 people
- Sponsor
- UMC Utrecht
Colonic Neoplasms
Imatinib as Pre-operative Anti-Colon Cancer Targeted Therapy
In this proof-of-concept trial the investigators will study the effects of imatinib treatment on the biology of mesenchymal-type colon cancers.
- Trial name
- ImPACCT (NCT02685046)
- Testing
- Imatinib
- Where
- 3 sites in Netherlands
- Volunteers
- 5 people
- Sponsor
- UMC Utrecht
Arterial Calcification, Diabetes Mellitus Type 2
A Randomized, Placebo-controlled, Double Blind Trial to Investigate Whether Vitamin K2 Can Influence Arterial Calcification in Patients With Type 2 Diabetes
Arterial calcification is an independent predictor of coronary events associated with a 3-4 fold increased risk of cardiovascular events. Currently, no effective intervention exists to reduce arterial calcification.
- Trial name
- Vitacal (NCT02839044)
- Testing
- Menaquinone-7
- Where
- Netherlands
- Volunteers
- 68 people
- Sponsor
- UMC Utrecht
Rectal Cancer
RECTAL BOOST Study
Randomized controlled trial in which the effect is investigated of a radiation boost in addition to standard chemoradiation in patients with locally advanced rectal cancer on complete response rate defined as pathological…
- Trial name
- RECTAL BOOST (NCT01951521)
- Testing
- Boost
- Where
- Netherlands
- Volunteers
- 128 people
- Sponsor
- UMC Utrecht
Refraction Error, Myopia
The MORE Study: Manifest vs. Online Refraction Evaluation
The assessment of the refractive state of the eye is a fundamental and important part of ophthalmic and optometric clinical practice.
- Conditions
- Refraction Error, Myopia, Astigmatism
- Trial name
- MORE (NCT03313921)
- Testing
- Online Manifest Refraction
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
RSV Infection, Respiratory Syncytial Virus Infections
RESCEU Study, Defining the Burden of Disease of RSV in Older Adults
The REspiratory Syncytial virus Consortium in EUrope (RESCEU) is an Innovative Medicine Initiative (IMI) funded by the EU under the H2020 framework to define and understand the burden of disease caused by human respiratory…
- Conditions
- RSV Infection, Respiratory Syncytial Virus Infections, Bronchiolitis
- Trial name
- NCT03621930
- Where
- 3 sites in Belgium, Netherlands and 1 more
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Schizophrenia, Schizoaffective Disorder
Prednisolone Addition for Patients With Recent-onset Psychotic Disorder
Treatment with prednisolone can be used as a proof of concept to investigate the possibility of immune modulation as a treatment for schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychotic Disorder NOS
- Trial name
- NCT02949232
- Testing
- Prednisolone
- Where
- 4 sites in Belgium, Denmark and 1 more
- Volunteers
- 42 people
- Sponsor
- UMC Utrecht