Clinical trials: sponsored by Unity Health Toronto
Diabetes Mellitus, Non-Insulin-Dependent, Heart Failure
Saxagliptin and Cardiac Structure and Function
Diabetes is associated with a substantially increased risk of heart failure, which is associated with substantial morbidity and mortality.
- Trial name
- SCARF (NCT02481479)
- Testing
- Saxagliptin
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Cannabis Use, Driving Impaired
Neural Correlates of Driving and Cannabis
Driving is a set of complex tasks and requires use of multiple cognitive domains, including attention, planning, and memory. In laboratory studies, the main psychoactive component in cannabis, delta-9-tetrahydrocannabinol (THC)…
- Trial name
- NCT03581058
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Unity Health Toronto
Nephrolithiasis
Mirabegron And Ureteral Stent-related Pain (MAP) Trial
Ureteric stents are used often following ureteroscopy for prevention of obstruction from edema and/or stone fragments. Up to 75% of patients experience pain following stenting, as well as lower urinary tract symptoms (LUTS) such…
- Trial name
- MAP (NCT04286152)
- Testing
- Mirabegron 50 MG
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- Unity Health Toronto
Sleep, Pregnancy
Perinatal Effects of Mindfulness Phone App Use in Pregnancy (PaMPPr Study)
There is evidence to show that mindful meditation has a positive impact on health. To date, all the studies done to investigate the effect of mindfulness on pregnancy outcomes have been done through a traditional 8-10 weeks…
- Trial name
- PaMPPr (NCT03802734)
- Testing
- Mindful meditation phone app
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pelvic Organ Prolapse, Pessary
Extended Pessary Interval for Care (EPIC Study)
Objectives: Pelvic organ prolapse (POP) is a common condition for which pessaries are commonly used in conservative treatment. Despite their prevalence, there is no literature to guide the management of pessaries.
- Trial name
- EPIC (NCT01644214)
- Testing
- 6 month follow up for pessary check in the clinic setting
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Unity Health Toronto
Overactive Bladder
Educating Patients on Management of Overactive Bladder: Written Versus Verbal Instructions
Background: Overactive bladder (OAB) is a common condition among postmenopausal women, requiring a multifaceted treatment approach that requires patient retention of information given to them in clinic.
- Trial name
- NCT02197533
- Testing
- Written List
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Clavicle Fracture, Fractures
Conservative Treatment Versus Operative Plate Fixation for Acute, Displaced Fractures of the Distal Clavicle
This is a multicentre randomized clinical trial prospectively comparing operative treatment versus conservative (nonoperative) care in the management of displaced distal (Type II) clavicle fractures.
- Trial name
- NCT00872105
- Testing
- Non-operative Treatment, Operative Treatment
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- Unity Health Toronto
Nonunion of Bone Graft, Fractures Non Union
Reamer Irrigator Aspirator (RIA) vs Autogenous Iliac Crest Bone Graft (AICBG) for the Treatment of Non-unions
The specific question the investigators will seek to answer is: can the Reamer Irrigator Aspirator (RIA) provide a bone graft source for the treatment of nonunions that is equally effective to Autogenous Iliac Crest Bone Graft…
- Trial name
- NCT01382485
- Testing
- RIA harvesting group, AICBG harvesting group
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Pain, Disruption or Dehiscence of Closure of Sternum or Sternotomy
Use of a Support Bra to Reduce Pain and Improve Surgical Healing in Women Undergoing Sternotomy for Cardiac Surgery
The primary purpose of this study is to examine whether a properly fitted support bra on females improves their quality of life post-sternotomy. Specifically, does a support bra reduce discomfort, pain and wound dehiscence.
- Conditions
- Pain, Disruption or Dehiscence of Closure of Sternum or Sternotomy, Quality of Life
- Trial name
- NCT02453945
- Testing
- Adjustable Support Bra
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
The Effect of Viscous Fiber on Glycemic Control in Individuals With Diabetes
Purpose of Study (The Effect of Viscous Fiber on Glycemic Control (VF \& GC) in Individuals with Diabetes Mellitus. According to the World Health Organization, about 347 million individuals are living with diabetes.
- Trial name
- VF&GC (NCT02629263)
- Testing
- Viscous Fiber
- Where
- Canada
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Risk Factor, Hypercholesterolemia
The Effect of Viscous Dietary Fibers on LDL-cholesterol
This systematic review and meta-analysis is aimed to assess the effect of commonly consumed viscous fibers on blood lipids including LDL-C, non-HDL-C, and ApoB.
- Trial name
- NCT04133805
- Testing
- viscous fiber
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obesity, Morbid, Stem Cells
Effect of Weight Loss Surgery on Stem Cells.
Obesity and diabetes are linked to increased risk for health problems such as heart attack, stroke, and death. At the cellular level, obesity and diabetes increase levels of harmful inflammatory cells (M1 macrophages) and…
- Conditions
- Obesity, Morbid, Stem Cells, Cardiovascular Morbidity
- Trial name
- NCT04132531
- Testing
- Bariatric (weight loss) surgery
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Fine Motor Function Deficit and Visual Neglect Post-stroke
iPad Technology for HOME Rehabilitation in Patients After Stroke: iHOME Acute/Chronic
A pilot randomized, two parallel group study comparing an iPad software game application versus standard care in post-stroke patients.
- Trial name
- NCT01836159
- Testing
- iPad Intervention, Standard/ Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 29 people
- Sponsor
- Unity Health Toronto
Arthroplasty, Replacement, Knee
COPE: Cannabinoids to Obviate Pain Experiment After Knee Replacement
Total knee replacement is a major and painful orthopaedic (joint and bone) surgery where the knee joint is replaced with an artificial joint.
- Trial name
- COPE (NCT03675971)
- Testing
- Cannabinol
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Unity Health Toronto
Cardiac Arrest, Sepsis
Improving Outcomes After Time Sensitive Prehospital Interventions: Rescu Epistry
Rescu Epistry includes data points pertaining to prehospital and in-hospital clinical treatments and responses to therapy, survival to discharge and functional outcome data for all cases.
- Conditions
- Cardiac Arrest, Sepsis, Trauma, Stroke
- Trial name
- NCT04110912
- Testing
- This is a registry and no interventions are taking place.
- Where
- 3 sites in Canada
- Sponsor
- Unity Health Toronto
Social Determinants of Health, Poverty
Implementation and Impact of an Online Tool Used in Primary Care to Improve Income Security
We will evaluate the acceptability, feasibility and impact of an online tool that helps patients identify financial benefits that they are entitled to at six clinic sites over a three month period.
- Conditions
- Social Determinants of Health, Poverty, Social Isolation, Social Marginalization
- Trial name
- NCT02959866
- Testing
- online income tool
- Where
- 2 sites in Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Heart Failure
Comparison of BNP and NT-proBNP in the Management of Patients With Chronic and Acute Heart Failure
The purpose of this study is to compare the changes in B-type Natriuretic Peptide (BNP) and amino-terminal fragment of proBNP (NT-proBNP) in outpatients managed in the heart failure (HF) clinic initiated on the Angiotensin…
- Trial name
- NCT04107220
- Testing
- Sacubitril/Valsartan
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Unity Health Toronto
Glaucoma, Open-Angle
Saccadic Eye Movements Are Impaired In Glaucoma
The purpose of this study is to determine whether rapid eye movements called saccades are impaired in glaucoma, a neurodegenerative disease of visual pathways.
- Trial name
- NCT01254058
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Diabetic Macular Edema
Cytokine Levels in Patients With Persistent Diabetic Macular Edema Treated With Triamcinolone Acetonide
Diabetic macular edema refers to swelling (fluid accumulation) in the center of the retina. The retina is like the film of a camera and is located in the back of the eye.
- Trial name
- NCT02221453
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Unity Health Toronto
Diabetic Macular Edema
Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Diabetic Macular Edema
Diabetic macular edema refers to swelling (fluid accumulation) in the center of the retina. The retina is like the film of a camera and is located in the back of the eye.
- Trial name
- NCT02441907
- Testing
- aflibercept
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Unity Health Toronto