Clinical trials: completed, sponsored by Unity Health Toronto
Autism Spectrum Disorder
Exploring the Efficacy and Usability of the My Autism Passport (MAP).
To address developmental service navigation by families of children with autism spectrum disorder (ASD) an innovative paper-based tracking tool called the Pediatric Developmental Passport (Passport) was created by Dr.
- Trial name
- NCT04259671
- Testing
- My Autism Passport (MAP) Application
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Cognitive Dysfunction
Musical Attention Control and Executive Function Training for Adults With MDD
The investigators have developed music-based cognitive training sessions derived from Neurologic Music Therapy (NMT) techniques.
- Conditions
- Major Depressive Disorder, Cognitive Dysfunction, Suicide
- Trial name
- NCT05694156
- Testing
- Music-based cognitive training
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Primary Care
Screening for Poverty and Related Social Determinants to Improve Knowledge of and Links to Resources (SPARK) Pilot Study
Research question and objectives This pilot study will help us answer the following research question: Is it feasible to conduct a large cluster randomized controlled trial (RCT) of an intervention that consists of routine…
- Trial name
- SPARK Pilot (NCT04211025)
- Testing
- Modest, Intensive
- Where
- 6 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Unity Health Toronto
COVID-19
Coagulopathy of COVID-19: A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation Versus Standard Care
Coagulopathy of COVID-19 afflicts approximately 20% of patients with severe COVID-19 and is associated with need for critical care and death.
- Trial name
- NCT04362085
- Testing
- Therapeutic Anticoagulation
- Where
- Canada
- Volunteers
- 465 people
- Sponsor
- Unity Health Toronto
Homeless Persons
Effect of a Rent Subsidy and Mentoring on Youth Transitioning Out of Homelessness
Compared to the vast amount of literature about the risk factors associated with young people entering and becoming entrenched in homelessness, much less is known about how to facilitate and sustain transitions off the streets.
- Trial name
- NCT03779204
- Testing
- Mentorship, Rent Subsidies
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Housing
Housing Conditions: Evaluation, Advocacy and Research in Toronto Community Housing
This project will examine whether a health promotion campaign using community organizing and joint advocacy by a coalition of tenants, health providers, social service agencies and advocates can lead to improvements in building…
- Trial name
- HEARTH (NCT04131101)
- Testing
- Community Organizing
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Quality of Health Care, HIV/AIDS
Using Electronic Medical Record Data to Improve HIV Primary Care
This cluster randomized control trial examines whether an audit and feedback study improves care of patients living with HIV/AIDS in a family health team setting.
- Conditions
- Quality of Health Care, HIV/AIDS, Electronic Health Records
- Trial name
- NCT04107233
- Testing
- Audit and Feedback
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared to standard initiation…
- Trial name
- NCT02568722
- Testing
- Standard RRT initiation, Accelerated RRT initiation
- Where
- 105 sites in United States, Australia and 13 more
- Volunteers
- 3,019 people
- Sponsor
- Unity Health Toronto
Subarachnoid Hemorrhage
Ketamine Infusion in Neurologic Deficit
Subarachnoid hemorrhage (SAH) or bleeding in the brain as a result of ruptured aneurysm is a devastating type of stroke. Many patients who undergo emergent neurosurgery to repair the aneurysm and remove the bleeding suffer from…
- Trial name
- KIND (NCT02636218)
- Testing
- Ketamine, 0.9% NaCl
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
HIV Testing, HIV Infections
Near Patient Study of the OraQuick ADVANCE® HIV-1/2 Rapid Antibody Test in Oral Fluid and Fingerstick Whole Blood
Point-of-care (POC) tests for HIV are easy to use, rapid and provide accurate results while the patient is still in-front of a healthcare provider (HCP).
- Trial name
- NCT04810559
- Testing
- OraQuick ADVANCE® HIV-1/2 Rapid Antibody Test
- Where
- 4 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cancer
Genetics Adviser: Evaluating a Digital Decision Support Tool for Genetic Results
Oncologists are increasingly using genomic sequencing to diagnose and optimize care for their patients. A consequence of this technology is its capacity to detect a patient's risk for thousands of current and future conditions or…
- Trial name
- NCT04725565
- Testing
- Genetics ADvISER Decision Aid Plus Standard Genetic Counselling, Standard Genetic Counseling
- Where
- 3 sites in Canada
- Volunteers
- 133 people
- Sponsor
- Unity Health Toronto
Treatment Resistant Depression, Major Depressive Disorder
Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate a short-term treatment option for major depressive disorders by administering nitrous oxide gas.
- Trial name
- SMILE (NCT04957368)
- Testing
- Nitrous Oxide 99 %, Oxygen + Midazolam
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Traumatic Brain Injury, Trauma, Nervous System
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury
The prevention of secondary brain injury is a primary goal in treating patients with severe traumatic brain injury (TBI). Secondary brain injury results from tissue ischemia induced by increased vascular resistance in the at-risk…
- Conditions
- Traumatic Brain Injury, Trauma, Nervous System, Reperfusion Injury, Ischemia, Brain
- Trial name
- NCT03176823
- Testing
- CellAegis Technologies autoRIC device, Best Practice Management of Traumatic Brain Injury
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Distress, Emotional, Stress Response Among Nursing Professionals During the COVID-19
Digital Interventions to Understand and Mitigate Stress Response
Stress, anxiety, distress, and burnout are exceptionally high among healthcare workers at the frontline of the COVID-19 pandemic.
- Conditions
- Distress, Emotional, Stress Response Among Nursing Professionals During the COVID-19, Stress Reaction; Acute
- Trial name
- NCT05923398
- Testing
- Digital Intervention Group
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Hypercholesterolemia
The Combined Portfolio Diet and Exercise Study
The purpose of this study is to determine whether a dietary portfolio of cholesterol-lowering foods (viscous fibres, soy protein, plant sterols and nuts) further enhanced by increased levels of monounsaturated fatty acids (MUFA)…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- PortfolioEx (NCT02481466)
- Testing
- Portfolio diet and structured exercise, DASH-like diet and structured exercise, Portfolio diet and routine exercise
- Where
- 4 sites in Canada
- Volunteers
- 232 people
- Sponsor
- Unity Health Toronto
Treatment Resistant Depression, Major Depressive Disorder
Stellate Ganglion Block for Major Depressive Disorder.
This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB).
- Trial name
- NCT04727229
- Testing
- Bupivacaine Hydrochloride, Normal Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Sudden Cardiac Death, Sudden Cardiac Arrest
Canadian Sudden Cardiac Arrest Network
The overall aim of the project is to develop a national registry to accurately measure the burden of Sudden Cardiac Arrest (SCA) among the general Canadian population.
- Trial name
- C-SCAN (NCT03642587)
- Testing
- There is no intervention in this study.
- Where
- 6 sites in Canada
- Volunteers
- 82,054 people
- Sponsor
- Unity Health Toronto
Operating Room Efficiency
Minimizing Peri-operative Time Delays, Maximizing Operating Room Efficiency: A Pilot Study
The primary objective is to prospectively identify Operating Room (OR) time delays from the time the patient who is undergoing total laparoscopic hysterectomy enters the OR to exiting the OR.
- Trial name
- NCT03257384
- Testing
- Black box recording of surgery
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Vaginal Speculum Examination
Gynaecological Speculum Examination: Straight Horizontal Insertion Versus Vertical Insertion and Rotation.
This study compares two different types of speculum insertion to determine the level of discomfort they might cause. This study compares the straight horizontal insertion (SHI) of the speculum and the vertical insertion and…
- Trial name
- NCT02708615
- Testing
- Type of speculum vaginal insertion method
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Uterine Fibroid
Design of an Intra-operative Blood Conservation Pathway at Open Myomectomy
Uterine fibroids are benign uterine masses that can be removed through a surgical procedure called a myomectomy. Myomectomy is often associated with a significant amount of blood loss for the patient.
- Trial name
- NCT03211481
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto