Clinical trials: sponsored by Universitätsklinikum Hamburg-Eppendorf
Atopic Dermatitis
ADBest TREAT Registry
Atopic dermatitis is a chronic inflammatory skin disease associated with intense pruritus, recurrent eczematous lesions, sleep disturbance, and reduced quality of life.
- Trial name
- ADBest-TREAT (NCT07904546)
- Testing
- Abrocitinib, Baricitinib, Upadacitinib
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Psoriasis, Psoriatic-arthritis
PsoBest - The German Psoriasis Registry
Treatment of moderate to severe Psoriasis (Pso) and Psoriasis-Arthritis (PsA) is largely confined to systemic therapy in Germany. Systemic therapy includes conventional systemic therapy (e.g.
- Trial name
- NCT01848028
- Where
- Germany
- Volunteers
- 3,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Obesity (BMI > 35), Obesity (BMI > 35) and Diabetes Mellitus
HUGO-SLEEVE: Evaluating the Feasibility of Robotic Sleeve Gastrectomy With a New Platform
Severe obesity is a chronic condition that can lead to a range of serious health problems. One common treatment option is sleeve gastrectomy, a weight-loss operation in which the size of the stomach is reduced.
- Conditions
- Obesity (BMI > 35), Obesity (BMI > 35) and Diabetes Mellitus, Obesity (BMI > 35) and Dyslipemia, Obesity (BMI > 35) and High Blood Pressure
- Trial name
- NCT07884994
- Testing
- Sleeve Gastrectomy using Hugo RAS platform
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Blood Pressure, Intraoperative Hypotension
Perioperative Personalized Blood Pressure Management: IMPROVE-multi
Rates of major complications and mortality in the first weeks after surgery remain very high: postoperative mortality is still around 2% in central Europe and the United States.
- Conditions
- Blood Pressure, Intraoperative Hypotension, Postoperative Complications, Surgery
- Trial name
- IMPROVE (NCT05416944)
- Testing
- Personalized blood pressure management
- Where
- Germany
- Volunteers
- 1,272 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
SCAD, ACS (Acute Coronary Syndrome)
Spontaneous Coronary Artery Dissection - AntipLatelet Therapy Intensity in Guided coNservative Management (SCAD-ALIGN) Trial
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome in which blood flow to the heart muscle is reduced or interrupted.
- Trial name
- SCAD-ALIGN (NCT07683923)
- Testing
- Acetylsalicylic acid ASA, ASA plus Clopidogrel
- Where
- 5 sites in Canada, Germany and 3 more
- Volunteers
- 3,518 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Kidney Injury, Acute Kidney Injury (AKI)
Hamburg Acute Kidney Injury Study (HAKIS)
The Hamburg Acute Kidney Injury Study (HAKIS) is a prospective observational cohort study aimed at investigating the mechanisms, risk factors, and clinical determinants of acute kidney injury (AKI) trajectories and consequences.
- Trial name
- HAKIS (NCT07338669)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cholangiocarcinoma, Klatskin Tumor
Endoscopic Radiofrequency Ablation for Unresectable Cholangiocarcinoma
The goal of this clinical trial is to learn about radiofrequency ablation in patients with unresectable bile duct cancer who receive systemic chemotherapy and bile duct stenting.
- Conditions
- Cholangiocarcinoma, Klatskin Tumor, Bile Duct Cancer, Liver Cancer
- Trial name
- ACTICCA-2 (NCT06175845)
- Testing
- Intraductal biliary radiofrequency ablation
- Where
- 9 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Parkinson's Disease (PD), Tremor
Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Parkinson's Disease Tremor
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage.
- Trial name
- tACS_PD_TR (NCT06993571)
- Testing
- Active-tACS, Unlocked-tACS
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Aortic Valve Stenosis
Balloon- Versus Self-Expanding Intraannular TAVI in Small Aortic Annuli
In Europe TAVI is now recommended for treatment of aortic valve stenosis from the age of 70 years. When performing TAVI in young patients, lifetime management becomes important in terms of anticipated TAVI-in-TAVI procedures when…
- Trial name
- BALANCE (NCT07794306)
- Testing
- Meril Octapro+ THV System, Abbott Navitor/Navitor Vision THV system
- Where
- Germany
- Volunteers
- 510 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Persistent Idiopathic Facial Pain (PIFP)
Deciphering Persistent Orofacial Pain - PIFP
Persistent non-dental orofacial pain is common yet poorly characterised, and its pathophysiology remains largely unknown. Two clinically similar entities are distinguished: post-traumatic trigeminal neuropathic pain (PTNP), in…
- Trial name
- NCT07791004
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypotension During Surgery
Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
The PLANE trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep MAP above 65mmHg compared to routine care without PLC in patients having…
- Trial name
- PLANE (NCT06950606)
- Testing
- Pneumatic leg compression
- Where
- Germany
- Volunteers
- 238 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Delirium, Delirium Prevention
Evaluation of a Hospital Program to Prevent Postoperative Delirium in Older Patients
Postoperative delirium is a common complication in older adults undergoing surgery. It is characterized by an acute and fluctuating disturbance of attention, awareness, and thinking.
- Conditions
- Postoperative Delirium, Delirium Prevention, Multicomponent Care Program, Older Adults (60 - 85 Years Old)
- Trial name
- EvaDel (NCT07787832)
- Testing
- Multicomponent delirium prevention program
- Volunteers
- 720 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Intraoperative Hypotension
Continuous Finger-cuff Arterial Pressure Monitoring and Intraoperative Hypotension During Non-cardiac Surgery: the Randomized DETECT II Trial
This is a randomized trial (1) investigating whether continuous finger-cuff - compared to intermittent oscillometric - arterial pressure monitoring reduces the amount of intraoperative hypotension (specifically, from the start of…
- Trial name
- DETECT II (NCT06753097)
- Testing
- Continuous finger-cuff arterial pressure monitoring
- Where
- Germany
- Volunteers
- 930 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Loneliness, Mental Well-being
Creating Encounters Between Generations - Together Instead of Alone (GemsE)
Elderly people and children and young people (CYP) and from families with mentally ill parents are particularly affected by loneliness.
- Conditions
- Loneliness, Mental Well-being, Health-related Quality of Life
- Trial name
- GemsE (NCT07581171)
- Testing
- Mechanisms and effectiveness of intergenerational tandems
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Delirium, Dementia
Delirium and Cognitive Impairment Development in Hospitalized Older Adults Under Isolation Conditions
The goal of this observational study is to examine if older patients who need to be under isolation precautions due to multidrug resistant bacteria or other reasons have an increased risk of suffering from delirium or cognitive…
- Conditions
- Delirium, Dementia, Cognitive Impairment
- Trial name
- DELiso (NCT07114458)
- Where
- Germany
- Volunteers
- 404 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cutaneous Squamous Cell Carcinoma (CSCC), Advanced Cutaneous Squamous Cell Carcinoma
D-TECT: Pretreatment D-dimers and Disease Control in Advanced cSCC Treated With Cemiplimab
D-TECT is a prospective, multicenter, non-interventional observational study investigating whether pretreatment D-dimer levels predict disease control in patients with locally advanced or metastatic cutaneous squamous cell…
- Conditions
- Cutaneous Squamous Cell Carcinoma (CSCC), Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
- Trial name
- D-TECT (NCT07684066)
- Testing
- Pretreatment D-dimer status
- Where
- 15 sites in Austria, Germany
- Volunteers
- 116 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Frailty, Frailty in Older Adults
Comparison of Preoperative Frailty Assessment Tools
Frailty is a significant risk factor for postoperative complications and functional decline. Preoperative assessment of frailty is therefore recommended in all older adults.
- Conditions
- Frailty, Frailty in Older Adults, Frailty/Sarcopenia
- Trial name
- PREFAS (NCT06889545)
- Testing
- Assessment of frailty using multiple tools
- Where
- Germany
- Volunteers
- 584 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Frail Elderly Syndrome
Home-based Prehabilitation for Elderly Patients
As a consequence of the increasing life expectancy hospitals are seeing a growing number of elderly patients undergoing elective surgery.
- Trial name
- TRAilty (NCT03964363)
- Testing
- Unsupervised home-based physical prehabilitation
- Where
- 3 sites in Germany
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
This Study Aims to Evaluate the Safety Profile and Tissue Changes After Biostimulatory Treatments to the Face in Healthy Volunteers
Analysis of Safety and Tissue Interaction of Injectable Biosmulators
The goal of this clinical trial is to analyse tissue changes in the pre-auricular region after injectable (Poly-L-Lactic-Acid/Calcium-Hydroxylapatit) biostimulatory interventions in healthy volunteers.
- Trial name
- Biostimulation (NCT06993558)
- Testing
- Poly-L-Lactic Acid (Sculptra) injection, Calcium Hydroxyapatite
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf