Clinical trials: sponsored by Universitätsklinikum Hamburg-Eppendorf
Study Group
Hands-on Emotion Awareness and Regulation Group Training for Autistic Adolescents (HEART)
The study focuses on a group training program called HEART aimed at helping adolescents with Autism Spectrum Disorder improve emotional regulation.
- Trial name
- HEART (NCT07009522)
- Testing
- Hands-on Emotion Awareness and Regulation Group Training for Autistic Adolescents - HEART
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mental Disorder in Adolescence, Depression in Adolescence
Adolescent Psychiatry Inpatients: Self-reported Parent-adolescent Communication Quality and Treatment Outcome
The quality of parent-adolescent communication has been found to be associated with adolescent mental health. However, little is known about the association of parent-adolescent communication and adolescent mental health in the…
- Conditions
- Mental Disorder in Adolescence, Depression in Adolescence, Anxiety
- Trial name
- NCT06633458
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Congenital Heart Disease, Heart Failure
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
Advances in surgical and medical care have led to improved outcomes in patients with congenital heart disease (CHD). As a consequence, the majority of patients nowadays survives to adulthood (adults with CHD, that is, adult CHD…
- Conditions
- Congenital Heart Disease, Heart Failure, Transplant; Complication, Failure, Arrythmia
- Trial name
- ARTORIA-R (NCT04848844)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Deep Brain Stimulation, Parkinson's Disease (PD)
Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop
The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and…
- Trial name
- NCT07139093
- Testing
- DBS-coupled tACS
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postinduction Hypotension
Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk…
- Trial name
- INDUCT-Multi (NCT07538388)
- Testing
- Continuous Norepinephrine Administration
- Where
- 4 sites in Germany
- Volunteers
- 446 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ebola Vaccine
Immunity Induced by VSV-EBOV and Assessment of a Booster Dose in Individuals at Potential Occupational Risk for Exposure
This study is a multi-center, open label, randomized phase 3b trial to assess the durability of Immunity induced by the Ebolavirus Vaccine VSV-EBOV ( with or without booster vaccination) in individuals at potential occupational…
- Trial name
- PREPARE (NCT05959421)
- Testing
- ERVEBO® (rVSV∆G-ZEBOV-GP)
- Where
- 2 sites in Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Hepatitis B
A Heterologous Protein Prime/MVA Boost Therapeutic Hepatitis B Vaccine Candidate
This study is an open-label, ascending dose phase 1a trial to assess the safety and immunogenicity of a heterologous protein prime/MVA boost therapeutic hepatitis B vaccine
- Trial name
- NCT05727267
- Testing
- HEPLISAV B; TherVacB, TherVacB
- Where
- 2 sites in Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Positive Expectations
Positive Expectation Effects on Early Emotional Processing
Insights into the mechanisms of expectation effects in the emotional domain can be invaluable for the development of potential therapeutic interventions for mood disorders.
- Trial name
- NCT07615530
- Testing
- Saline Nasal Spray
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave
The CLIMATE-III Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-III (NCT06890208)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Myeloma Multiple, Myeloma
Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple Myeloma
This study is researching an experimental five-drug combination called etentamig, isatuximab, bortezomib, lenalidomide, and dexamethasone.
- Trial name
- CONQUISTADOR (NCT07600151)
- Testing
- Etentamig, Isatuximab, Bortezomib + Lenalidomide + Dexamethasone
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Isolated Cervical Dystonia
Cerebellar Transcranial Direct Current Stimulation (tDCS) in Patients With Isolated Cervical Dystonia (CD)
Cervical dystonia (CD) is a movement disorder characterized by involuntary muscle contractions of the neck, leading to abnormal head postures and movement, pain and impaired motor function.
- Trial name
- NCT07014384
- Testing
- Anodal and cathodal ctDCS
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Migraine
BIOMIGA: Results From Magnetic Resonance Imaging
The projects comprising in the multicenter BIOMIGA project have been preregistered earlier with ID NTC04503083 at clinicaltrials.gov. Here the imaging subproject within the overall BIOMIGA aims is specified.
- Trial name
- NCT06633484
- Testing
- functional magnetic resonance imaging
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Ischemic Stroke, Atrial Fibrillation
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study will determine whether early, comprehensive, rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care.
- Trial name
- EAST-STROKE (NCT05293080)
- Testing
- Medical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version), Usual care for atrial fibrillation
- Where
- Germany
- Volunteers
- 1,746 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depressive Symptoms, Expectations
Disentangling Pharmacological and Expectation Effects in Antidepressant Discontinuation
Antidepressant medication is established as an evidence-based, guideline-recommended treatment for Major Depressive Disorders. In the past decades, prescriptions of antidepressant medication have markedly increased, with a…
- Conditions
- Depressive Symptoms, Expectations, Antidepressants
- Trial name
- PHEA (NCT05191277)
- Testing
- Treatment 'discontinuation of antidepressant medication', Treatment 'continuation of antidepressant medication', Expectation 'high'
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Migraine Disorders
Trigeminal Brainstem Mapping 2: Higher Cortical Strucureas as Well as Subnuclei of the Spinal Trigeminal Nucleus
In previous studies clustering of the three branches of the trigeminal nerve in brainstem were shown, cerebellum and periaqueductal gray.
- Trial name
- NCT06535880
- Testing
- Electric Current Stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Multiple Myeloma, Multiple Myeloma in Relapse
Combination Treatment of Belantamab Mafodotin and Venetoclax in Treatment of Relapsed and Refractory t(11;14) Multiple Myeloma
The goal of this clinical trial is to learn about the safety and efficacy of the drug combination belantamab mafodotin and venetoclax, with or without the addition of dexamethasone, in patients with relapsed/refractory multiple…
- Trial name
- BELI(E)VE (NCT05853965)
- Testing
- Belantamab mafodotin, Venetoclax
- Where
- 5 sites in Germany
- Volunteers
- 45 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Aortic Valve Stenosis
Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality
Randomized controlled, multi-center trial randomizing patients with symptomatic severe aortic stenosis at low to intermediate operative risk of mortality in a 1:1 fashion to transcatheter aortic valve implantation (TAVI) or…
- Trial name
- DEDICATE (NCT03112980)
- Testing
- Transcatheter aortic valve implantation, Surgical aortic valve replacement
- Where
- 43 sites in Germany
- Volunteers
- 1,414 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Multiple Myeloma
Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone
A Clinical Phase II, multicenter, Open-label study evaluating iNduction, consolidation and maintenance treatment with Isatuximab (SAR650984), Carfilzomib, LEnalidomide and Dexamethasone (I-KRd) in Primary diagnosed high-risk…
- Trial name
- NCT03104842
- Testing
- Isatuximab, Carfilzomib, Lenalidomide
- Where
- 17 sites in Germany
- Volunteers
- 246 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke, Hand Functions
Bifocal Transcranial Alternating Current Stimulation Targeting the Frontoparietal Network in Stroke Patients
Hand and arm function is often significantly impaired in stroke patients, making its recovery a primary goal in rehabilitative treatment.
- Conditions
- Stroke, Hand Functions, Cerebrovascular Disease, Brain Diseases
- Trial name
- NCT06809959
- Testing
- In-phase-tACS, Out-of-phase-tACS
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf