Clinical trials: sponsored by Université de Sherbrooke
First Episode Psychosis
Recovery With Exogenous Ketones and Antipsychotics
The RECAP project will evaluate the clinical and metabolic effects of adding exogenous ketones to antipsychotic (AP) treatment in young adults with a first episode of psychosis (FEP).
- Trial name
- RECAP (NCT07122531)
- Testing
- Medium chain triglyceride oil
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Provoked Vestibulodynia
Efficacy of Dry Needling in Reducing Pain During Sexual Intercourse
Chronic vulvar pain is a highly prevalent and debilitating condition affecting up to 16% of women. The most common subtype of vulvar pain, provoked vestibulodynia (PVD), is characterized by a sharp pain at the entry of the vagina…
- Trial name
- NCT07534345
- Testing
- Real dry needling
- Where
- 4 sites in Canada
- Volunteers
- 170 people
- Sponsor
- Université de Sherbrooke
Prediabetic State
Restoring 24-hour Substrate Rhythmicity to Improve Glycemic Control by Timing of Lifestyle Factors
Exercise is well-known to improve skeletal muscle energy metabolism and is an established intervention to improve muscle insulin sensitivity and to counter the development of type 2 diabetes (T2D).
- Trial name
- TIMED (NCT05123963)
- Testing
- High-intensity interval training
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Stroke
Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence.
- Trial name
- CN-NINM (NCT06386510)
- Testing
- Strength training, Cranial nerve non-invasive neuromodulation
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes
Improving Insulin Sensitivity in Patients With Type 2 Diabetes Via Repeated Cold-induced Shivering Thermogenesis
Type 2 Diabetes Mellitus (T2DM) is a widespread health condition characterized by impaired ability of the body to maintain glucose homeostasis.
- Trial name
- NCT07573917
- Testing
- Cold exposure with shivering
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Obesity, Childhood, Lifestyle Intervention
Obesity-fertility Cohort Study: Protocol for the Assessment of Children Aged 6-12 Years and Their Mothers
Maternal preconception obesity and adverse gestational metabolic health increase the risk of childhood obesity in offspring. A group of investigators from Université de Sherbrooke therefore developed a lifestyle intervention…
- Conditions
- Obesity, Childhood, Lifestyle Intervention, Preconception Care
- Trial name
- NCT06402825
- Testing
- Fit-for-Fertility program
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cardiovascular Diseases, Frailty
Managing Frailty Through Mobilization in Males and Female Inpatients With Cardiovascular Disease
Frailty describes the overall health of a person. Inpatients with cardiovascular problems have a higher risk for frailty - or the sick are more likely to get sicker - causing longer hospital stays, hospital readmission, and…
- Trial name
- NCT06810661
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Sherbrooke
Asthma, Inflammation
PROPULSION SANTE: Inflammometry to Improve the Diagnostic Trajectory in Situations of Suspected Asthma in Children and Adults
The objective of this observational study is to assess the relevance of inflammometry (based on the measurement of fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC)) as a tool for prioritizing respiratory…
- Conditions
- Asthma, Inflammation, Asthma in Children
- Trial name
- PROPULSION (NCT06981169)
- Testing
- FeNO, blood sample
- Where
- 3 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- Université de Sherbrooke
Frailty at Older Adults
Preventing Frailty in Hospital Through Mobilizing
Frailty describes the variability in aging and explains why two people of the same chronological age may look very different. Higher frailty leads to poor quality of life, disability, and death.
- Trial name
- NCT06802289
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Université de Sherbrooke
Dyslipidemias
Group Medical Visits for Patients With Dyslipidemia
Physicians' interventions to promote the improvement of lifestyle habits have been shown to be effective. However, such interventions remain underutilized due to barriers such as lack of time, confidence, and compensation.
- Trial name
- PARTAGE-D (NCT07543718)
- Testing
- Group medical visits
- Where
- Canada
- Volunteers
- 288 people
- Sponsor
- Université de Sherbrooke
Cardiovascular
The Role of EDHFs on Blood Pressure Following a Bout of Prolonged Sitting
Canadians spend most of their day in sedentary postures (i.e., sitting, lying, reclining). While the beneficial impacts of physical activity on the heart are well-established, less is known about the consequences during time…
- Trial name
- NCT07396857
- Testing
- Fluconazole 150 mg
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Total Knee Arthroplasty
REST-Knee: A Pilot RCT of 72-Hour Knee Immobilization and Pain Outcomes
Postoperative pain following total knee arthroplasty (TKA) is often difficult to manage, particularly with the increasing use of outpatient surgery where patients recover at home.
- Trial name
- REST-Knee (NCT07511842)
- Testing
- Knee Extension Brace (Zimmer-type), Early Mobilization (Standard Care)
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- Université de Sherbrooke
Dyspnea, Chronic Obstructive Pulmonary Disease Severe
Alleviating Dyspnea With Non-Invasive Neuromodulation
The goal of this feasibility sham-controlled randomized trial is to assess the feasibility of studying non-invasive neuromodulation techniques, specifically transcutaneous vagal nerve stimulation (tVNS) and transcutaneous…
- Trial name
- PNEURO (NCT06985628)
- Testing
- Transcutaneous vagal nerve stimulation (tVNS), Transcutaneous electrical nerve stimulation (TENS)
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Université de Sherbrooke
Long COVID Syndrome
A Fasting Pilot Study for Long COVID
Background Long COVID (LC) is a chronic multisystemic condition which substantially impact the quality of life. Despite the staggering burden of LC, there is still no effective treatment.
- Trial name
- NCT07418567
- Testing
- prolonged fasting
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes
Brown Adipose Tissue Metabolism in Type 2 Diabetes
Activation of brown adipose tissue (BAT) by cold exposure. BAT thermogenesis and BAT volume of metabolic activity will be assessed by Positron-Emitting-Tomography (PET/CT) and MRI/MRS imaging and new pharmacological methods to…
- Trial name
- GB8 (NCT05092945)
- Testing
- Cold exposure, Oral Nicotinic acid
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Lipoprotein Lipase Deficiency
Postprandial Fatty Acid Metabolism in Subjects With Lipoprotein Lipase Deficiency
Lipoprotein lipase (LPL) is an enzyme that plays an important role in removing triglycerides (TG) (molecules that transport dietary fat) from the blood.
- Trial name
- AGL12 (NCT04227678)
- Testing
- Heparin, liquid meal
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus Type 2
Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.
- Trial name
- CB5 (NCT05934409)
- Testing
- Bariatric surgery, Nicotinic Acid
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Pain
Comparison of the Efficacy of an Empowered Relief Single-Session Versus Standard Care for Reducing Postoperative Pain Following Elective Orthopedic Surgery: A Randomized Controlled Trial
The purpose of this study is to evaluate the efficacy and acceptability of the French-Canadian version of ER compared to standard care in reducing postoperative pain and improving recovery outcomes at 6-week and 3-month…
- Trial name
- ER-CHUS -Ortho (NCT07392099)
- Testing
- Empowered Relief (ER) consists of a single-session, 2-hour group class.
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- Université de Sherbrooke
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Public Health
Cohort as Part of Undergraduate Medical Studies at the University of Sherbrooke
The main goals of this project are to support the research training of undergraduate medical students at the University de Sherbrooke and promote planning of health services a better knowledge of the prevalence, social, and…
- Trial name
- NCT03928509
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 6,000 people
- Sponsor
- Université de Sherbrooke