Clinical trials: sponsored by Université de Sherbrooke
Overweight and Obesity, Pregnancy Complications
Healthy for my Baby- RCT of a Lifestyle Intervention for Overweight Women in Preconception
The purpose of this study is to determine whether an intervention combining motivational interviewing and follow-up with a mobile phone application will help overweight women and their partners adopt healthy lifestyle habits in…
- Conditions
- Overweight and Obesity, Pregnancy Complications, Health Behavior, Life Style
- Trial name
- NCT04242069
- Testing
- Healthy for my Baby, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Healthy Aging
Effect of a Two-month Carbohydrate-restricted Diet on Energy Metabolism in a Seniors' Residence
The present study will assess the effects on glucose, ketones and other blood biomarkers fuels, cognition, quality of life, physical activity and well-being of a reduced carbohydrate menu (R-CHO) for 2 months in a population…
- Trial name
- SAGE (NCT06022094)
- Testing
- 2 months of reduced carb menus
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
First Episose Psychosis, Metabolic Disease
The ATP Project (Antipsychotic-TEP-Psychosis)
The goal of this observational study is to the early impacts of psychosis and antipsychotic medications on brain metabolism in young adults recently diagnosed with a first episode of psychosis.
- Conditions
- First Episose Psychosis, Metabolic Disease, Psychosis; Episode
- Trial name
- ATP (NCT06651112)
- Testing
- Antipsychotic drugs
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Université de Sherbrooke
Menopause
Health, Imaging, and Cognition Across the Menopausal Transition
This observational cross-sectional study aims to better understand how the menopausal transition affects brain energy metabolism and cognition.
- Trial name
- MOSAIC (NCT07021664)
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Kidney Failure, Chronic
Acetoacetate and Acetate Metabolism in Patients With Chronic Kidney Failure.(RENO-TEP)
The objective of this study is to nake a comparison between 11c-acetate and 11c-acetoacetate kidney uptake in chronic kidney failure patients.
- Trial name
- RENO-TEP (NCT05968391)
- Testing
- PET scan metabolic day
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Asthma Control
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called "remission") when given earlier in their disease, before asthma becomes severe.
- Trial name
- HOTHOT (NCT07309614)
- Testing
- Dupilumab Prefilled Syringe
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 150 people
- Sponsor
- Université de Sherbrooke
Intensive Care Unit ICU, Vasopressor
Canadian Critical Care Comparative Effectiveness Platform
The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial.
- Conditions
- Intensive Care Unit ICU, Vasopressor, Platelet, Nutrition
- Trial name
- CEPEC (NCT06605144)
- Testing
- 1- Vasopressor - Mean arterial pressure 56-60, 2- Vasopressor - Mean arterial pressure 61-65, 3- Vasopressor - Mean arterial pressure 66-70
- Where
- 11 sites in Canada, New Zealand and 1 more
- Volunteers
- 5,500 people
- Sponsor
- Université de Sherbrooke
Diagnosis, Inflammation
Diagnosing Asthma With Clinically Accessible, Non-invasive, and Efficient Tests: a Child-inclusive Translational Investigation
Asthma is a common inflammatory respiratory disease affecting 11% of Canadians, but its diagnosis remains challenging, leading to delays in treatment or overtreatment.
- Conditions
- Diagnosis, Inflammation, Asthma in Children, Asthma
- Trial name
- DIVE 2 (NCT07011394)
- Testing
- FeNO, Blood eosinophil count
- Where
- 3 sites in Canada
- Volunteers
- 123 people
- Sponsor
- Université de Sherbrooke
Fragile X Syndrome
Effect of CANnabidiol on Anxiety and GABAergic Function in Individuals With Fragile-X Syndrome
This study focuses on the therapeutic relevance of the endocannabinoid (eCB) system for the treatment of Fragile-X syndrome (FXS), the primary hereditary cause of autism spectrum disorder (ASD).
- Trial name
- CANAX (NCT06261502)
- Testing
- CBD Oral Solution
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Université de Sherbrooke
Developmental Dysplasia of the Hip (DDH), Congenital Hip Dysplasia
Manual Intervention and Congenital Hip Dysplasia in Infants
Developmental dysplasia of the hip (DDH) is a developmental abnormality of the infant hip in which the acetabulum does not adequately cover the femoral head. Standard conservative treatment commonly includes a Pavlik harness.
- Trial name
- NCT07756814
- Testing
- Manual therapy
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke
Endometriosis
Improving Access to Pelvic Health Physiotherapy for Endometriosis
This is a mixed-methods study aimed to generate new evidence to help optimize access to pelvic health physiotherapy (PHPT) for women living with endometriosis in the province of Quebec (Canada).
- Trial name
- ENDO-RM (NCT07731776)
- Where
- Canada
- Volunteers
- 264 people
- Sponsor
- Université de Sherbrooke
Kinesiophobia (Fear of Movement), Experimental Pain
Pain Beliefs and Intracortical Excitability During Experimental Pain
Pain can influence the way the motor system functions. However, responses to pain vary widely between individuals, and this variability may be partly related to pain-related beliefs such as kinesiophobia.
- Trial name
- NCT07688525
- Testing
- Topical Capsaicin Cream (1%)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Liver Fibrosis/NASH
Stimulating Fat Tissue Storage With Niacin to Reduce Fat Accumulation in the Liver.
Metabolic dysfunction-associated steatotic liver disease (MASLD) (aka non-alcoholic fatty liver disease), commonly occurring in individuals with obesity and type 2 diabetes can lead to liver inflammation/ fibrosis.
- Conditions
- Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Liver Fibrosis/NASH, Non-Alcoholic Steato-Hepatitis (NASH)
- Trial name
- AGL13 (NCT06843148)
- Testing
- Niacin (250mg)
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Université de Sherbrooke
Vulvodynia
Efficacy of High Intensity Laser for Provoked Vestibulodynia
This is a multicenter randomized controlled trial (RCT) investigating the effects of laser treatments in women suffering from provoked vestibulodynia compared to a sham-laser treatment.
- Trial name
- Laser_RCT (NCT05597358)
- Testing
- High Intensity Laser Therapy (HILT)
- Where
- 4 sites in Canada
- Volunteers
- 145 people
- Sponsor
- Université de Sherbrooke
Developmental Coordination Disorder (DCD)
Therapeutic Climbing for Children With DCD
This study looks at whether therapeutic climbing - indoor climbing activities guided by therapists - can help children with Developmental Coordination Disorder (DCD).
- Trial name
- Climbing TDC (NCT07609563)
- Testing
- CO-OP-based group therapeutic climbing intervention
- Volunteers
- 16 people
- Sponsor
- Université de Sherbrooke
Amyotrophic Lateral Sclerosis
Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a rare neurodegenerative disease resulting in loss, primarily, of the motor neurons in the motor cortex, brainstem and spinal cord.
- Trial name
- NCT05974579
- Testing
- 89Zr-DFO-AP-101
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Complex Renal Cyst
Surveillance of Complex Renal Cysts - The SOCRATIC Study
One third of individuals aged >60 years will be diagnosed with at least one renal cyst following abdominal imaging. These cystic lesions are categorized according to the Bosniak classification which categorizes cysts according to…
- Trial name
- SOCRATIC (NCT04558593)
- Testing
- Active surveillance, Surgery
- Where
- 18 sites in Canada, France
- Volunteers
- 330 people
- Sponsor
- Université de Sherbrooke
Breast Mass, Breast Cancer
Predicting Breast Cancer With the BRAVE System
Breast cancer predominates among cancer diagnoses in Canadian women. It accounts for around 25% of new cases and contributes to 13% of all cancer-related deaths.
- Trial name
- BRAVE (NCT06498388)
- Testing
- Stiffness measurement by visco-elastography
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Université de Sherbrooke
Chronic Pain
DNIC Using Deep Learning and Artificial Intelligence
Chronic pain (CP) is disabling for people triggering important costs for society. A deficit of diffuse noxious inhibitory controls (DNIC) is one of the CP mechanisms.
- Trial name
- NCT04896827
- Testing
- Conditioned pain modulation test
- Where
- Canada
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Pregnancy, Pelvic Floor Dysfunction
Female Reproductive Health in Canadian Armed Forces
This is a mixed-method study aimed at gathering new evidence on reproductive health among female service members in the Canadian Armed Forces (CAF).
- Conditions
- Pregnancy, Pelvic Floor Dysfunction, Military Personnel, Contraception
- Trial name
- BEARH2025 (NCT07524764)
- Where
- Canada
- Volunteers
- 1,121 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke