Clinical trials: sponsored by Université de Sherbrooke
Healthy Children
Outdoor Science Education and Child Well-being in Primary Schools: Protocol for a Cluster Randomized Controlled Trial on Learning, Connection to Nature, Eco-anxiety, and Stress
The goal of this randomized controlled trial is to learn if an outdoor science education intervention can improve primary school students' learning and well-being when compared to an indoor classroom-based science education…
- Trial name
- Bio-Explo (NCT07147634)
- Testing
- Outdoor science education, Indoor classroom-based science education
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
HPV, Cervical Cancers
Self-sampling for HPV Screening
To offer large-scale HPV self-sampling in Québec, it is essential to first demonstrate the most effective pathway for patient recruitment, proper sample collection, and safe continuity of care.
- Trial name
- HPVselftest (NCT07273383)
- Testing
- HPV self-sampling test
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Asthma, Asthma in Children
Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma
Asthma is characterised by episodic symptoms (attacks) caused by airway inflammation and decreased airflow to the lungs. It affects 10% of the Canadian population and is the most common chronic disease in childhood.
- Conditions
- Asthma, Asthma in Children, Diagnosis, Inflammation
- Trial name
- DIVE (NCT05992519)
- Testing
- ¸FeNO
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Université de Sherbrooke
Time of the Crowning of the Fetal Head, Levator Ani Avulsion
The Effect of Crowning Time on Levator Ani Muscle Avulsion
Levator ani muscle is one of the main components of perineal muscles and plays a crucial role in urinary continence and pelvic organ support.
- Conditions
- Time of the Crowning of the Fetal Head, Levator Ani Avulsion, Labor Delivery, Postpartum
- Trial name
- NCT07210788
- Where
- Canada
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Low-back Pain, Fibromyalgia
Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain
The primary aim of this study is to document the feasibility and acceptability of an intervention consisting of pain neuroscience education and reconsolidation therapy with propranolol in adults suffering from chronic pain…
- Trial name
- NCT05085782
- Testing
- Propranolol Hydrochloride, Reactivation procedure, Pain neuroscience education
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Blood Pressure Management, Blood Pressure Monitoring, Ambulatory
Impact of Resistance Training Intensity on Blood Pressure
The goal of the clinical trial is to understand the effect of two resistance training protocols employing different loading intensities (% of 1 repetition maximum; 1-RM), but with standardized effort intensity (2 repetitions in…
- Conditions
- Blood Pressure Management, Blood Pressure Monitoring, Ambulatory, Blood Pressure, High, Blood Pressure
- Trial name
- HEART (NCT06845514)
- Testing
- Condition LL-RE, Control, Condition HL-RE
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans
Veterans in Canada are twice as likely as the general population to experience chronic pain. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Conditions
- Chronic Pain, PTSD - Post Traumatic Stress Disorder, Quality of Life (QOL)
- Trial name
- VR & CN-NINM (NCT07137845)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke
Colorectal Cancer, Breast Cancer
Impact of Aerobic Exercise on the Anticancer Immune Response in Patients Receiving Cancer Treatment
The goal of this clinical trial is to determine to what extent anticancer immune cells mobilized by aerobic exercise exhibit migratory and functional capacity towards cancer cells in patients undergoing treatment for breast or…
- Conditions
- Colorectal Cancer, Breast Cancer, Non Metastatic Cancer
- Trial name
- Immuno-Ex (NCT06911970)
- Testing
- Exercise
- Where
- 2 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Université de Sherbrooke
Fibromyalgia
TENS Therapy to Reduce Exercise-Induced Pain in Women With Fibromyalgia
The goal of this clinical trial is to evaluate the short-term (24-hour) effect of conventional transcutaneous electrical nerve stimulation (TENS) compared to Sham TENS on pain induced by resistance training in women with…
- Trial name
- TENSXFibro (NCT06834308)
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Université de Sherbrooke
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH)
How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver
Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
- Trial name
- AGL14 (NCT07133854)
- Testing
- Imaging PET/MRI, Stable isotope infusions, meal test
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Glioblastoma Multiforme, Relapse
IA Carboplatin + Radiotherapy in Relapsing GBM
Treatment of glioblastoma involves an optimal surgery, followed by a combination of radiation and temozolomide chemotherapy. Progression-free survival (PFS) with this treatment is only 6.9 months and relapse is the norm.
- Trial name
- NCT03672721
- Testing
- IA Carbo+ Radiation
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Université de Sherbrooke
Glioblastoma Multiforme, Relapse
Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma
The standard of care for glioblastoma (GBM) treatment involves maximal resection followed by concomitant radiotherapy and temozolomide.
- Trial name
- NCT06356883
- Testing
- IA Carboplatin + IA Caelyx, IA Carboplatin + IA Etoposide Phosphate
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Université de Sherbrooke
Triple-Negative Breast Cancer
Triple Negative Breast Cancer and Celecoxib. Pilot Study
Relapses occur in 20 to 30% of patients with early-stage triple-negative breast cancer (TNBC), which is characterized by the absence of three receptors: the estrogen receptor (ER), progesterone receptor (PR) and human epidermal…
- Trial name
- NCT07104266
- Testing
- Celecoxib (Celebrex)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke
Anxiety, Pain
Colposcopy Anxiety and the Role of Pre-procedure Nursing Intervention
Colposcopy is essential for the diagnosis and prevention of cervical cancer. However, receiving screening results and being informed of the need to undergo a colposcopic examination are significant sources of anxiety for…
- Trial name
- NCT07092189
- Testing
- Pre-colposcopy counseling by a clinical nurse, Treatment as usual: regular call to schedule the appointment without pre-procedure conseilling
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Université de Sherbrooke
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Neuromodulation to Manage Chronic Pain
In Canada, veterans suffer from chronic pain at twice the rate of the general population. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Trial name
- VR & CN-NINM (NCT07065396)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Parkinson Disease, Alzheimer Disease
Effect of Exercise, Endocannabinoids and Ketones on Cerebral Metabolism in a Cognitive Disorders Population
A two months intervention in which two groups of cognitive disorders, Parkinson and Alzheimer's disease, will receive 50g/day of a commercial MCT supplement combined with supervised aerobic exercise 3 times/week.
- Trial name
- PARKA (NCT04322461)
- Testing
- Betaquik MCT supplement
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Université de Sherbrooke
MCI
BRain Energy Activation With Ketones to Prevent Alzheimer's Disease
A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS).
- Trial name
- BREAK-AD (NCT04466735)
- Testing
- Active group
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Social Anxiety
Evidence-based Internet Cognitive-behavioral Therapy for Social Anxiety
The objectives of the study are to 1) to translate and adapt iCBT Shyness Program to the Canadian context; 2) to examine the completion and effectiveness of the Canadian adapted, including the French translated and English iCBT…
- Trial name
- iCBT-SAD (NCT06403995)
- Testing
- Self-referred, undirected Internet-based cognitive behavioral therapy for social anxiety, Recommended, undirected Internet-based cognitive behavioral therapy for social anxiety, Recommended, directed Internet-based cognitive behavioral therapy for social anxiety
- Where
- 2 sites in Canada
- Volunteers
- 252 people
- Sponsor
- Université de Sherbrooke
Anxiety, Postnatal Depression
Transdiagnostic Internet Cognitive-behavior Therapy for Mixed Anxiety and Depressive Symptoms in Postnatal Women
This research project aims to examine the acceptability and efficacy of a French-Canadian adaptation of a postnatal anxiety and depression program.
- Trial name
- postnataIiCBT (NCT06778096)
- Testing
- Postnatal anxiety and depression iCBTprogram
- Where
- 4 sites in Canada
- Volunteers
- 226 people
- Sponsor
- Université de Sherbrooke
Organ Transplant Failure or Rejection, Brain Death
Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)
The investigators hypothesize that preconditioning neurologically deceased organ donors with the calcineurin inhibitor tacrolimus will improve short and long-term transplant survival without causing harm.
- Conditions
- Organ Transplant Failure or Rejection, Brain Death, Ischemic Reperfusion Injury
- Trial name
- CINERGY (NCT05148715)
- Testing
- Tacrolimus
- Where
- 9 sites in Canada
- Volunteers
- 414 people
- Sponsor
- Université de Sherbrooke