Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Peritoneal Carcinomatosis, Pseudomyxoma Peritonei
Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed
The purpose of this study is to register the follow-up data of patients who, because of a peritoneal surface malignancy, will undergo cytoreductive surgery and HIPEC.
- Conditions
- Peritoneal Carcinomatosis, Pseudomyxoma Peritonei, Peritoneal Mesothelioma
- Trial name
- HIPEC (NCT01617382)
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy (CP)
Targeted Muscle Activation During Strength Training for Children With CP
Cerebral palsy (CP) is the most common cause of physical disability in children and is associated with muscle weakness, spasticity, and impaired motor control.
- Trial name
- TACT-CP (NCT07800221)
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spina Bifida, Neuromuscular Diseases
Metformin in Children With Motor Deficit
Obesity with insulin resistance in the paediatric population provides an increasing challenge. Children with neurological or neuromuscular diseases are even more prone to obesity: their locomotor impairment leads to an…
- Trial name
- NCT00720161
- Testing
- Metformin
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Poor Glycemic Control, Quality of Life
Benefits of a Bolus Calculator in Pediatric Patients on Multiple Daily Insulin Injections
It it hypothesized that children and adolescents with type 1 diabetes, who are counting carbohydrates can achieve better metabolic control by concurrent use of the Accu-Chek Aviva Expert.
- Trial name
- NCT06141629
- Testing
- accu chek Aviva Expert, Accu Chek Aviva Nano
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
3D Foot Scanning and Customized 3D-Printed Foot Orthotics to Reduce Pressure on the Feet of Healthy Adults
The number of people with diabetes mellitus worldwide is increasing rapidly and is expected to rise to 439 million by 2030, or 7.7% of the total adult world population.
- Trial name
- NCT07781618
- Testing
- Foot orthotics
- Where
- Belgium
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Twin Pregnancy, Dichorionic
Lifestyle Intervention to Improve Twin Pregnancy Outcomes
The goal of this clinical trial to is assess the benefits of holistic lifestyle interventions, including nutrition, physical activities, and mindfulness, aiming to reduce preterm birth in twins, potentially revolutionizing twin…
- Trial name
- LIFETWIN (NCT07270640)
- Testing
- LIFETWIN
- Where
- 4 sites in Belgium
- Volunteers
- 81 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Late Life Depression (LLD)
The Leuven Longitudinal Late-Life Depression Study
The goal of this observational study is to learn about the long-term effects of late-life depression (LLD) in adults aged 60 and older. LLD is depression that begins for the first time later in life.
- Trial name
- L4D (NCT07768098)
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Triple Negative Breast Cancer (TNBC), Early Setting
LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients With Triple Negative Breast Cancer
LESLIE is a multicentric randomized controlled trial in patients with triple negative breast cancer receiving neoadjuvant chemo/immunotherapy (NAT).
- Trial name
- LESLIE (NCT06831955)
- Testing
- Exercise Therapy, Fasting-Mimicking Diet, SOC
- Where
- 10 sites in Belgium
- Volunteers
- 356 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Insufficient Bone Volume Prior to Implant Surgery
The Tooth Collar Technique
The aim of this study is to evaluate wound healing after the application of the Tooth Collar Technique (TCT) for bone augmentation in the upper or lower jaw.
- Trial name
- TCTechnique (NCT07753525)
- Testing
- Tooth Collar Technique
- Where
- 4 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Visual Impairment, Cerebral Visual Impairment
Body Image, Identity Development, and Social Media Use Among Youth With Visual Impairment: A Single Case Intervention Study
1. Introduction This 3-week single case intervention study is funded by the Horizon Europe Research Program and is part of the VIPPSTAR project (Project 101156763 - VIPPSTAR "Visually Impaired children and adolescents: bridging…
- Conditions
- Visual Impairment, Cerebral Visual Impairment, Visual Impairments
- Trial name
- VIPPSTAR_G3KUL (NCT07741500)
- Testing
- Body image intervention
- Where
- 2 sites in Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tooth Loss and Rehabillitation
Custom Provisionalisation
Fully digital immediate implant treatment by means of fully guided implant placement and custom designed provisionalisation with a individual designed abutment and temporary PMMA crown leads to better esthetic outcomes than free…
- Trial name
- Azento (NCT07731854)
- Testing
- Fully guided implant placement, Free handed implant placement, individualised abutment + digital prepared provisional crown
- Where
- 2 sites in Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pediatric Cancer
Securing Access to Innovative Molecules in Oncology and Hematology for Children, Adolescents and Young Adults
It involves collecting safety and efficacy data, under the actual conditions of use of off label and compassionate use medicines in children and adolescents approved in humans before 2007, using a validated tool (Ennov EDC) and…
- Trial name
- (SACHA) (NCT07727694)
- Testing
- data collection
- Where
- 6 sites in Belgium
- Volunteers
- 1,600 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gingival Recession, Generalized
Ultrasonographic Vascular Supply
Pre-operative ultrasound enables visualization of mandibular arterial branches relevant to flap design in mucogingival surgery. This study documents the pre-and post operative course of these arteries in four CAF procedures using…
- Trial name
- NCT07727707
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mitral Valve Prolapse, Ventricular Arrythmia
Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
Mitral valve prolapse (MVP) affects up to 3% of the general population and a small subset of patients is at risk for ventricular arrhythmias.
- Trial name
- ALARM-PILOT (NCT06378996)
- Testing
- 14-day rhythm monitoring
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hip Arthropathy Associated With Other Conditions
Long-term Aseptic Revision & Advanced Hip Arthroplasty Database
Total hip arthroplasty (THA) volumes continue to rise each year as the population ages and indications broaden. Increasingly, younger patients require hip replacement for conditions beyond primary osteoarthritis or fractures.
- Trial name
- LARA (NCT07481448)
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hospital Costs
Variability in ASD (Adult Spinal Deformity) Value
The study will examine if variability in created value (outcome/costs) over the care cycle for ASD patients can be explained by patient and treatment characteristics.
- Trial name
- VIAV (NCT04638894)
- Testing
- Surgical treatment of patients with adult spinal deformity
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Foot and Ankle Arthrodesis, Foot and Ankle Osteotomy
Foot and Ankle Arthrodesis or Osteotomy With Io-Fix Type Fixation
The recovery of foot and ankle arthrodesis and osteotomy is still plagued by the problem of delayed consolidation or even pseudo-arthrosis.
- Trial name
- NCT04812353
- Testing
- Follow-up of Io-Fix type fixation
- Where
- Belgium
- Volunteers
- 208 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Posterior Tibial Tendon Dysfunction
Biomechanical and Morphological Characterization of PTTD
Posterior tibial tendon dysfunction (PTTD) is a progressive condition of the tendon of the tibialis posterior muscle with symptoms of tendinopathy or even rupture.
- Trial name
- PTTD (NCT06260813)
- Testing
- Radiography, Ultrasound, MRI
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Disease
Skin Involvement in Dupuytren Surgical Treatment Outcome
Palmar skin is often retracted in Dupuytren disease (DD), making surgical management challenging and skin-preserving surgery difficult.
- Trial name
- Skin in DD (NCT07470684)
- Testing
- Suction cutometry, Ultrasound measurement, Microbiopsy for histological analysis
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven