Clinical trials: completed, sponsored by Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Disease
Inulin and Protein Fermentation in Hemodialysis Patients
An important group of protein-bound uremic retention solutes originate from protein fermentation in the colon. P-cresol is a putrefaction metabolite of tyrosine. Indole is generated by fermentation of tryptophan.
- Trial name
- NCT00695513
- Testing
- BENEO synergy1
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis
Comparison of 2 Treatment Regimens for Eradication of P Aeruginosa Infection in Children With Cystic Fibrosis
Treatment of new Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) can postpone chronic infection. Aim of the study: compare 2 Pa eradication regimens in children with new Pa infection.
- Trial name
- CCTOBI (NCT01400750)
- Testing
- oral ciprofloxacin plus inhaled colistin, TOBI
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Oncology, Medical, Hematologic Disease
Safety of Catheter Lock With or Without Heparin in Implanted Central Venous Catheters
Long-term central venous access devices are considered as safe for the administration of medication as chemotherapy, but are also used for blood sampling.
- Trial name
- NCT00994136
- Testing
- normal saline
- Where
- Belgium
- Volunteers
- 1,100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Carcinoma (Squamous Cell Carcinoma - Adenocarcinoma)
Early Metabolic Response in Locally Advanced Esophageal Cancer Undergoing Induction Chemoradiotherapy
Early metabolic response evaluation may predict clinical and histopathological response after neoadjuvant chemotherapy. Its value in neoadjuvant chemoradiotherapy (CRT) is unknown.
- Trial name
- NCT01269970
- Testing
- 18-FDG-PET-CT
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain, Fever
Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates
The purpose of this study is triple, i.e. document single dose pharmacokinetics and -dynamics of intravenous paracetamol in preterm and term neonates after a loading dose (20 mg/kg iv bolus paracetamol), document multiple dose…
- Trial name
- PARANEO (NCT00969176)
- Testing
- paracetamol
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epiphora
Prevention of Docetaxel Induced Dacryostenosis
The antineoplastic agent Docetaxel (Taxotere®) is approved for the treatment of patients with metastatic and locally advanced breast cancer and other malignancies.
- Trial name
- NCT00266838
- Testing
- Maxidex; Lacrystat
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inguinal Hernia
Effects of Lightweight Meshes in Laparoscopic Inguinal Hernia Repair on Quality of Life and Male Fertility Aspects
A randomized, prospective clinical trial analyzing whether the use of lightweight prostheses during laparoscopic inguinal hernia repair of male patients could have a beneficial effect on postoperative discomfort, chronic pain…
- Trial name
- NCT00925067
- Testing
- laparoscopic (TEP) inguinal hernia repair, lightweight TiMesh, lightweight VyproII
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glaucoma, Trabeculectomy
Usefulness of Topical Non-Steroidal Anti-Inflammatory Drugs or Steroids Before Trabeculectomy and Clinical Outcomes
Antiglaucoma medication have been shown to induce subclinical conjunctival inflammation in a considerable proportion of glaucoma patients.
- Conditions
- Glaucoma, Trabeculectomy, Fibrosis, Intraocular Pressure
- Trial name
- NCT00707421
- Testing
- ketorolac acetate, fluorometholone, artificial lacrimal tears
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
End Stage Renal Disease
Protein-Bound Uremic Retention Solutes in Long Nocturnal Hemodialysis
Although remarkable progress has been made, chronic kidney disease still poses a major burden on both individual patients, as well as on society as a whole.
- Trial name
- NCT00417105
- Testing
- hemodialysis
- Where
- 4 sites in Australia, Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Disease
The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis
Despite major advances in the treatment of chronic kidney disease, the age and sex matched mortality far exceeds that of the normal population.
- Trial name
- INVEST-PD (NCT00433264)
- Testing
- peritoneal dialysis
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hematologic Disease
Functional Evaluation of Two Types of Totally Implanted Venous Ports
Totally implanted venous access ports allow a safe delivery of medication, mainly chemotherapy, but are also used for blood sampling.
- Trial name
- NCT00484848
- Testing
- Vortex port and Celsite port
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hemodialysis, Renal Transplantation
Influenza Vaccination in Hemodialysis Patients and Renal Transplant Recipients
Disturbances of acquired immunity are considered to be responsible, at least partly, for the high infection rate and inadequate response to vaccinations observed in hemodialysis (HD) patients and renal transplant recipient (RTR).
- Trial name
- NCT00776750
- Testing
- trivalent split influenza vaccine
- Where
- Belgium
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dialysis
Citrate Anticoagulation vs. Heparin-Coated Dialyzers
Hemodialysis causes contact activation of the coagulation pathway (1). For this reason, unfractionated or low molecular weight heparins are administered in daily practice to prevent thrombosis of the dialyzer and blood circuit…
- Trial name
- NCT00395824
- Testing
- anticoagulation procedure
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven