Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Metastatic Colorectal Cancer
Positron Emission Tomography - Computed Tomography (PET-CT) Cetuximab Project
Molecular imaging with positron emission tomography (PET) using [18F] fluorodeoxyglucose (FDG) has been suggested as an early, sensitive marker of tumour response to anticancer drugs by monitoring the changes in glucose…
- Trial name
- NCT00828620
- Testing
- Imaging study
- Where
- 6 sites in Belgium
- Volunteers
- 21 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Catheter-related Infection
Optimalisation of Therapeutic Drug Monitoring (TDM) of Vancomycin in Patients With Central Venous Port Devices
Recently, it was reported that when vancomycin levels are determined after port sampling, levels can be falsely increased potentially leading to wrong dose adjustments.
- Trial name
- NCT01661361
- Testing
- blood levels
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteers
In Vivo Inhibition Profile of CYP2C9 by Pineapple Juice
The goal of this study is to evaluate the actual potential for in vivo pineapple juice inhibition with CYP2C9 substrates in human volunteers with use of diclofenac as a marker of CYP2C9 activity.
- Trial name
- NCT01649492
- Testing
- pineapple juice (Carrefour n°1) 500 ml/day 5 days
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functionality, Strength
Objective Assessment of Physical Activity in Older Adults
The purpose of the present study is to evaluate the validity of 2 objective measures of physical activity among older adults. In addition, the investigators will examine the influence of functionality, walking aids, walking speed…
- Conditions
- Functionality, Strength, Validity During Daily Activities, Physical Activity
- Trial name
- NCT01621035
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Strength Training, Muscle Strength, Muscle Mass, Inflammatory Processes
The Role of Mechanical Stress and Muscle Fatigue in Strength Gains
The purpose of this study is to compare the impact of different levels of mechanical stress and muscle fatigue in strength training conditions on muscle strength, muscle mass and inflammatory processes.
- Trial name
- NCT01216774
- Testing
- Strength training
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Test-retest Reliability, Validity
Test-retest Reliability of a Standard Protocol on the Biodex Dynamometer
The purpose of the present study is to evaluate test-retest reliability of a standard protocol on the Biodex dynamometer in older adults.
- Conditions
- Test-retest Reliability, Validity, Biodex Medical Systems III Dynamometer, Experimental Measure of Knee Extension Strength
- Trial name
- NCT01217684
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hyperparathyroidism, Hypertension
The Effect of Parathyroidectomy on Renal Function, Endothelial Function, and Blood Pressure
Secondary hyperparathyroidism (HPT) is a known complication of chronic renal failure. Elevated concentrations of parathyroid hormone (PTH) play a role not only in the pathogenesis of renal bone disease, but also in the…
- Trial name
- NCT00452049
- Testing
- parathyroidectomy
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Renal Transplant Disorder
Renal Tubular Acidosis in Incident Renal Transplant Recipients
Metabolic acidosis is a common complication in incident renal transplant recipients. Protracted acidosis may be associated with osteoporosis, inflammation, negative protein balance and malnutrition, and last but not least may…
- Trial name
- NCT01283880
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Disease
Study of the Compliance With Phosphorus Restricted Diet and Phosphate Binder Therapy in Hemodialysis Patients
Hyperphosphatemia is a common and severe complication in chronic kidney disease patients treated with hemodialysis. A phosphate restricted diet and oral phosphate binders are the cornerstones in the prevention and treatment of…
- Trial name
- NCT01509027
- Testing
- education by DVD, Standard care, Education by DVD and dietician
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Rejection of Renal Transplant, Renal Graft Loss
Reasons for Mycophenolate Mofetil Dose Reduction and Impact on Graft Outcome in Renal Transplant Recipients
Mycophenolate mofetil (MMF) decreases the risk of acute rejection and is associated with improved graft survival in renal transplant recipients.
- Trial name
- NCT01496703
- Testing
- no intervention, this is an observational retrospective trial
- Where
- Belgium
- Volunteers
- 749 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dialysis, Fistula
Study of Pain, Anxiety and Complications Related to Cannulation of Arteriovenous (AV) Fistula in Chronic Hemodialysis Patients
A. Pain and other disadvantages of AV fistula cannulation can be limited by using the so-called buttonhole technique. B. Till present in our center catheters with cylindrical points are used for cannulation of AV fistulas with…
- Trial name
- NCT00544492
- Testing
- catheter for AV fistula cannulation
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Pain
Disposition of Intravenous Ketorolac
The purpose of this study is: to document ketorolac disposition (concentration/time profile, protein binding, metabolism) and its covariates following intravenous (iv) administration of ketorolac right after caesarean section and…
- Trial name
- NCT01291472
- Testing
- Ketorolac Tromethamine
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prophylaxis
Cefazolin Pharmacokinetics: Elimination Clearance in Neonates
To document cefazolin disposition (concentration/time profile, protein binding, metabolism, renal elimination characteristics) and its covariates in neonates following intravenous administration of the drug at induction of…
- Trial name
- NCT01295606
- Testing
- Cefazolin
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Self-esteem, Personality
Psychological Assessment of Adults Seeking Orthodontic Treatment
Is their a association between the objective and subjective severity of a malocclusion, quality of life and self-esteem/personality (as modifier between objective/subjective severity and quality of life (cfr study Agou et al.…
- Conditions
- Self-esteem, Personality, Quality of Life, Malocclusion
- Trial name
- NCT01475773
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoid Osteoma
Treatment Outcome After Surgical Treatment of Osteoid Osteoma
Purpose of the study: To retrospectively determine the clinical results in an unselected group of consecutive patients with osteoid osteoma treated by surgery.
- Trial name
- NCT01466010
- Testing
- surgical removal of osteoid osteoma
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stage III Lung Cancer
External ValidatIon Trial of ASTER Trial
As the use of endoscopic ultrasonography for mediastinal diagnosis and/or staging is widely spread in Belgium, the investigators aimed to determine the number of mediastinoscopies needed to detect one additional mediastinal lymph…
- Trial name
- EVITA (NCT01332240)
- Testing
- Endoscopic ultrasonography
- Where
- 18 sites in Belgium
- Volunteers
- 255 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Idiopathic Rhinitis Patients, Healthy Controls
Neuro-immunological Analysis of Idiopathic Rhinitis Patients and Controls Treated With Capsaicin.
The term idiopathic rhinitis (IR) is used in this study to describe a patient group with following characteristics: patients with complaints of nasal obstruction, sneezing and/or rhinorrhea for a period of over 1 year, which…
- Trial name
- NCT01223820
- Testing
- Capsaicin
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gliomas
Advanced MR Techniques in Detection of Tumor Infiltration and Grading in Gliomas
In this study, we evaluate the role of diffusion kurtosis imaging (DKI) and MR spectroscopy (MRS), two advanced imaging techniques in magnetic resonance (MR) in grading and detection of microscopic infiltrating tumour in gliomas.
- Trial name
- NCT01225003
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Disease
Inulin and Protein Fermentation in Hemodialysis Patients
An important group of protein-bound uremic retention solutes originate from protein fermentation in the colon. P-cresol is a putrefaction metabolite of tyrosine. Indole is generated by fermentation of tryptophan.
- Trial name
- NCT00695513
- Testing
- BENEO synergy1
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Spasm, Diffuse
Botulinum Toxin Injection to Treat Diffuse Esophageal Spasm
This study evaluates the effect of botulinum toxin 100 U or saline, injected endoscopically in the distal esophagus, on symptoms and manometry pattern in patients with diffuse esophageal spasm.
- Trial name
- Botox (NCT01432782)
- Testing
- Botulinum Toxin Type A
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven