Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis
Comparison of 2 Treatment Regimens for Eradication of P Aeruginosa Infection in Children With Cystic Fibrosis
Treatment of new Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) can postpone chronic infection. Aim of the study: compare 2 Pa eradication regimens in children with new Pa infection.
- Trial name
- CCTOBI (NCT01400750)
- Testing
- oral ciprofloxacin plus inhaled colistin, TOBI
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Oncology, Medical, Hematologic Disease
Safety of Catheter Lock With or Without Heparin in Implanted Central Venous Catheters
Long-term central venous access devices are considered as safe for the administration of medication as chemotherapy, but are also used for blood sampling.
- Trial name
- NCT00994136
- Testing
- normal saline
- Where
- Belgium
- Volunteers
- 1,100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cardiovascular Surgical Procedure
Clinical Evaluation of Air Handling in Baby fx Oxygenator With Integrated Arterial Filter Versus Baby rx Oxygenator With Non Integrated Arterial Line Filter
The goal of the study is the evaluation of the air handling of a "new" type of oxygenator versus the standard model. The new type has an integrated arterial filter. The standard model has a non integrated arterial line filter.
- Trial name
- NCT01296685
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Preimplantation Genetic Diagnosis
Genome-wide Single Cell Haplotyping as a Generic Method for Preimplantation Genetic Diagnosis
The investigators previously developed approaches to SNP-, CNV- and haplo-type single human cells (Vanneste et al. 2009, Nature Medicine).
- Trial name
- NCT01336400
- Testing
- single cell haplotyping
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Attention-deficit/Hyperactivity Disorder
Toolkit for School Behavior Modification in Children With Attention-Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to examine the efficacy of the ADHD-Toolkit (a toolkit for school behaviour modification in primary school children with ADHD-behaviours) in terms of general improvement in ADHD symptoms, specific…
- Trial name
- NCT01330849
- Testing
- ADHD Toolkit, Waiting List Control group
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Carcinoma (Squamous Cell Carcinoma - Adenocarcinoma)
Early Metabolic Response in Locally Advanced Esophageal Cancer Undergoing Induction Chemoradiotherapy
Early metabolic response evaluation may predict clinical and histopathological response after neoadjuvant chemotherapy. Its value in neoadjuvant chemoradiotherapy (CRT) is unknown.
- Trial name
- NCT01269970
- Testing
- 18-FDG-PET-CT
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain, Fever
Pharmacokinetics, -Dynamics and Safety of Intravenous Paracetamol in Neonates
The purpose of this study is triple, i.e. document single dose pharmacokinetics and -dynamics of intravenous paracetamol in preterm and term neonates after a loading dose (20 mg/kg iv bolus paracetamol), document multiple dose…
- Trial name
- PARANEO (NCT00969176)
- Testing
- paracetamol
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Studying Spinal Cord Evoked Potentials in Patients With Intractable Pain.
Spinal Cord Evoked Potentials as a Tool to Investigate Sensorimotor Processing
The study first aim is to investigate the relationship between different patterns of electrode stimulation and peripheral sensory stimulation and spinal cord-evoked potentials to optimize spinal cord stimulation parameters .
- Trial name
- SCEPTISM (NCT01208805)
- Testing
- Recording spinal cord evoked potentials
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epiphora
Prevention of Docetaxel Induced Dacryostenosis
The antineoplastic agent Docetaxel (Taxotere®) is approved for the treatment of patients with metastatic and locally advanced breast cancer and other malignancies.
- Trial name
- NCT00266838
- Testing
- Maxidex; Lacrystat
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inguinal Hernia
Effects of Lightweight Meshes in Laparoscopic Inguinal Hernia Repair on Quality of Life and Male Fertility Aspects
A randomized, prospective clinical trial analyzing whether the use of lightweight prostheses during laparoscopic inguinal hernia repair of male patients could have a beneficial effect on postoperative discomfort, chronic pain…
- Trial name
- NCT00925067
- Testing
- laparoscopic (TEP) inguinal hernia repair, lightweight TiMesh, lightweight VyproII
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glaucoma, Trabeculectomy
Usefulness of Topical Non-Steroidal Anti-Inflammatory Drugs or Steroids Before Trabeculectomy and Clinical Outcomes
Antiglaucoma medication have been shown to induce subclinical conjunctival inflammation in a considerable proportion of glaucoma patients.
- Conditions
- Glaucoma, Trabeculectomy, Fibrosis, Intraocular Pressure
- Trial name
- NCT00707421
- Testing
- ketorolac acetate, fluorometholone, artificial lacrimal tears
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
End Stage Renal Disease
Protein-Bound Uremic Retention Solutes in Long Nocturnal Hemodialysis
Although remarkable progress has been made, chronic kidney disease still poses a major burden on both individual patients, as well as on society as a whole.
- Trial name
- NCT00417105
- Testing
- hemodialysis
- Where
- 4 sites in Australia, Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Disease
The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis
Despite major advances in the treatment of chronic kidney disease, the age and sex matched mortality far exceeds that of the normal population.
- Trial name
- INVEST-PD (NCT00433264)
- Testing
- peritoneal dialysis
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Failure
Citrate Anticoagulation During MARS Treatment
The optimal anticoagulation procedure during MARS treatment has not been defined. In various multi-centre trials, such as MARS-RELIEF, anticoagulation procedures are left to the discretion of the treating physician.
- Trial name
- NCT00695617
- Testing
- trisodiumcitrate
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hematologic Disease
Functional Evaluation of Two Types of Totally Implanted Venous Ports
Totally implanted venous access ports allow a safe delivery of medication, mainly chemotherapy, but are also used for blood sampling.
- Trial name
- NCT00484848
- Testing
- Vortex port and Celsite port
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hemodialysis, Renal Transplantation
Influenza Vaccination in Hemodialysis Patients and Renal Transplant Recipients
Disturbances of acquired immunity are considered to be responsible, at least partly, for the high infection rate and inadequate response to vaccinations observed in hemodialysis (HD) patients and renal transplant recipient (RTR).
- Trial name
- NCT00776750
- Testing
- trivalent split influenza vaccine
- Where
- Belgium
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Kidney Disease
Albumin Dialysis in End-Stage Renal Disease: Detoxification Capacity and Impact on Vascular Endothelial Function
The uremic syndrome is mainly related to the retention of a host of compounds, due to altered glomerular filtration and other factors of renal dysfunction, e.g. tubular secretion.
- Trial name
- NCT00442299
- Testing
- Fractionated Plasma Separation and Adsorption (FPSA)
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dialysis
Citrate Anticoagulation vs. Heparin-Coated Dialyzers
Hemodialysis causes contact activation of the coagulation pathway (1). For this reason, unfractionated or low molecular weight heparins are administered in daily practice to prevent thrombosis of the dialyzer and blood circuit…
- Trial name
- NCT00395824
- Testing
- anticoagulation procedure
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven