Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Vitamin D, Vitamin D and Calcium Homeostasis
Free Vitamin D and Steroid Metabolism in Endocrine Disorders
This clinical study aims to gain a better understanding of how different forms of vitamin D are processed in the body in healthy individuals, pregnant women, and patients with various hormonal (endocrine) and kidney (renal)…
- Trial name
- FREEDOM (NCT07268742)
- Testing
- Blood draw for the laboratory assessment
- Where
- Belgium
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphedema, Ketogenic Dieting
Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?
Lymphedema is a debilitating disorder that severely impairs the quality of life of the patients and requires life-long attention. Treatment for lymphatic dysfunction remains largely symptomatic, without real cure.
- Conditions
- Lymphedema, Ketogenic Dieting, Ketone Ester Supplement
- Trial name
- KETOLYMPH (NCT03991897)
- Testing
- Ketogenic diet, Isocaloric diet, Ketone ester supplementation
- Where
- Belgium
- Volunteers
- 81 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Implantable Cardioverter Defibrillator (ICD)
In-depth Interviews of Patients With ICDs
Although ICDs are effective in preventing sudden cardiac death, they can also profoundly affect patients' and partner/caregivers' emotional well-being, social relationships, and daily functioning.
- Trial name
- QoLICD-INSIGHT (NCT07258602)
- Testing
- semi-structured interview
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Implantable Cardioverter Defibrillator (ICD)
Patient-Reported Quality of Life in Patients With an Implantable-Cardioverter Defibrillator - A Cross-Sectional Observational Study
Patients at risk for life-threatening arrhythmias are eligible for the implantation of an implantable cardioverter-defibrillator (ICD), which has repeatedly shown improved survival.
- Trial name
- QoL-ICD I (NCT06654232)
- Testing
- quality of life questionnaires
- Where
- Belgium
- Volunteers
- 731 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Implantable Cardioverter Defibrillator (ICD)
Patient-Reported Quality of Life in Patients With an Implantable-Cardioverter Defibrillator - A Longitudinal Observational Study
Patients at risk for life-threatening arrhythmias are eligible for the implantation of an implantable cardioverter-defibrillator (ICD), which has repeatedly shown improved survival.
- Trial name
- QoL-ICD II (NCT06654284)
- Testing
- quality of life questionnaires
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Heart Failure, Non-ischemic Cardiomyopathy
Cardiac RadiothErapy For hEart faiLure
Preliminary data suggests that patients suffering from advanced refractory heart failure (HF) could benefit from single low dose whole heart external beam radiotherapy (EBRT).
- Conditions
- Heart Failure, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy
- Trial name
- CREFEL (NCT06661876)
- Testing
- 5 Gray Whole Heart external beam radiotherapy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hearing Disability
Assistant for LIstening and Communication Enhancement
As we get older, our hearing deteriorates and an age-related hearing loss can develop. Having a hearing loss can make it more difficult for people to understand conversations.
- Trial name
- ALICE (NCT05329922)
- Testing
- ALICE: Audiological rehabilitation
- Where
- Belgium
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ulcerative Colitis
Drug Repurposing - Statins as Microbiota Modulating Agents in Ulcerative Colitis
Evaluation of the microbiota modulation away from inflammation associated microbiota profile Bacteroides2 (Bact2) Evaluation of the effect of microbiota modulation on disease activity in ulcerative colitis and Crohn's disease…
- Trial name
- ReMiDy (NCT04883840)
- Testing
- Rosuvastatin 10mg
- Where
- 3 sites in Belgium
- Volunteers
- 177 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphedema Lower Extremity
Psychometric Properties of a Lymphedema-specific Quality of Life Questionnaire in Lower Limb Lymphedema
The goal of this observational study is to cross-validate the Lymphedema Functioning, Disability and Health Questionnaire for Lower Limb Lymphedema (Lymph-ICF-LL) in French and to investigate the responsiveness of the original…
- Trial name
- NCT07075549
- Testing
- Maintenance phase of Decongestive Lymphatic Therapy, Intensive phase of Decongestive Lymphatic Therapy
- Where
- 3 sites in Belgium, France
- Volunteers
- 451 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Physiological Responses
The Role of TRP Channels in DPN
The study aims to characterize the vascular response upon topical application of cinnamaldehyde, allyl isothiocyanate and capsaicin on feet skin in healthy volunteers.
- Trial name
- NCT07237022
- Testing
- Cinnamaldehyde, Allyl isothiocyanate (AITC), Capsaicin
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Influenza With Pneumonia, Invasive Pulmonary Aspergillosis
Influenza Associated Aspergillosis In-depth Investigation
This trial is aimed to study the immunological and pathological characteristics of influenza versus non-influenza severe community-acquired pneumonia patients in ICU.
- Trial name
- PIAS (NCT03748069)
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Disability Physical
Recovery From Disability After Geriatric-home Rehabilitation Versus Standard of Care: Pilot Study
At discharge after a hospitalization, many older people are not as able as before their hospital stay and have difficulty performing their daily activities at home.
- Trial name
- RECOVER@HOME (NCT06404138)
- Testing
- The Geriatric Activation Program (GAPP) Home version, Standard of care
- Where
- 2 sites in Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
ADPKD, Pain
Somatosensory Phenotyping of ADPKD
Over 60% of patients with ADPKD suffer from pain, mostly in the abdomen, flank and back, often leading to the diagnosis. It is challenging to manage and cure the pain; approximately 39% of patients are not satisfied with their…
- Trial name
- NCT06970028
- Testing
- Quantitative Sensory Testing, Questionnaires regarding pain and quality of life
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBD - Inflammatory Bowel Disease
Trial Comparing Multiport RObotic and Laparoscopic Surgery for Elective Colorectal Resections in IBD Patients (ACRO-IBD)
The aim of this study is to better understand whether robotic surgery leads to better outcomes than laparoscopy in terms of complications, recovery and quality of life.
- Trial name
- ACRO-IBD (NCT07230262)
- Testing
- Robotic colorectal surgery, Laparoscopic colorectal surgery
- Where
- Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Radiography, Spinal Fusion
Reassessing the Role of Routine Radiographs After Spinal Fusion Surgery
Routine radiographs are commonly obtained after spinal fusion surgery to monitor postoperative evolution and detect complications. However, the actual contribution of these radiographs to clinical decision-making remains unclear.
- Trial name
- RRASP (NCT07200557)
- Where
- Belgium
- Volunteers
- 978 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Functional Dyspepsia
The Effects of STW 5-II on Duodenal Mucosa and Symptoms in Functional Dyspepsia
The goal of this clinical trial is to find out whether a herbal medicine called STW 5-II can help improve gut health and symptoms in adults recently diagnosed with functional dyspepsia (FD)-a condition that causes frequent…
- Trial name
- DESTINY (NCT07198243)
- Testing
- STW 5-II
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postprandial Distress Syndrome, Functional Dyspepsia
Postprandial Distress Itopride Cohort Trial
Functional Dyspepsia (FD) is a common gastrointestinal disorder affecting about 7.2% of the population, characterized by gastroduodenal symptoms without an identifiable organic cause.
- Conditions
- Postprandial Distress Syndrome, Functional Dyspepsia, Epigastric Pain Syndrome
- Trial name
- PASSPORT (NCT07165301)
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hearing Disorders in Children, Hearing Loss
Automated Measures of Speech Intelligibility Using Brain Wave Recordings
Hearing loss is one of the most prevalent impairments in the world. The World Health Organization estimates that as of 2020, around 466 million people worldwide are affected by disabling hearing loss, of which 34 million are…
- Trial name
- CORGEE (NCT06402994)
- Testing
- Electrophysiological experiment, Speech audiometry
- Where
- 4 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Aortic Stenosis, Coronary Artery Disease
COronary and MICrocirculatory Measurements in Patients With Aortic Valve Stenosis.
Although concomitant coronary artery disease (CAD) is frequent in patients with severe aortic stenosis (AS), hemodynamic assessment of CAD severity in patients undergoing valve replacement for severe AS is challenging.
- Trial name
- COMIC-AS (NCT04420325)
- Where
- 3 sites in Belgium
- Volunteers
- 116 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Peri-implant Health
The Socket Shield Technique, a Prospective Cohort Study of 20 Patients
23 implants with socket shield were followed for 18 months. buccal bone thickness and survival rates registered.
- Trial name
- NCT05902715
- Testing
- oral implant placement with socket shield technique
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven