Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Subretinal Hemorrhage, Age-Related Macular Degeneration
Robotic Subretinal tPA Injection Study
In the RoTIS study, the investigators would like to test the robotic stabilizer for the subretinal injection of tPA in patients with subretinal hemorrhage during standard-of-care surgery.
- Trial name
- RoTIS (NCT06347107)
- Testing
- Robotic subretinal tPA injection
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke (CVA) or TIA, Carotid Artery Plaque
[18F]AlF-NOTA-octreotide PET/MRI in Carotid Artery Disease
This clinical trial aims to evaluate whether [¹⁸F]AlF-OC PET/MRI can characterize and quantify inflammation in carotid atherosclerotic plaques.
- Conditions
- Stroke (CVA) or TIA, Carotid Artery Plaque, Atherosclerosis Cardiovascular Disease, Carotid Arteriosclerosis
- Trial name
- NCT07104487
- Testing
- [18F]AlF-OC
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spastic Cerebral Palsy
Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy
This study investigates the effect of integrated Botulinum Neurotoxin A (BoNT) treatment on morphologic muscle and tendon properties, spasticity, joint stiffness, joint range of motion, muscle strength, gait and gross motor…
- Trial name
- NCT05126693
- Testing
- Botulinum Toxin treatment combined with a post-BoNT intensive physical therapy period guided by individualized treatment goals.
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Huntington Disease
Comparison Between [11C]UCB-J and [18F]SynVest-1 PET in HD.
Positron Emission Tomography (PET) is a functional imaging technique, which enables in vivo visualization of biological molecules expressed in human tissues.
- Trial name
- NCT05360082
- Testing
- [11C]UCB-J PET, [18F]SynVest-1 PET
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tibial Plateau Fracture
TPF Machine Learning Algorithms
To adopt a machine learning technique to decide whether operative or non-operative treatment will result in the best patient-outcome.
- Trial name
- NCT04983316
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Goniometry and Goniometric Measurement on Standardised Images in Dupuytren's Disease
Measuring range of motion (ROM) is essential in detecting musculoskeletal deficits, monitoring the effects of treatment and progression of the disease.
- Trial name
- Goniometry (NCT06263699)
- Testing
- ROM measurement of the MCP and PIP joints in digits 4 and 5
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Shoulder Arthroplasty
What Are the Determinants for RTW After SA
Shoulder arthroplasty is becoming increasingly common, due to ageing of the population. Historically, surgeons have been reluctant to use a shoulder replacement in younger patients.
- Trial name
- RTW after SA (NCT06281574)
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 122 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease
Long-term Longitudinal Imaging of Presynaptic Terminals in PD
AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD.
- Trial name
- NCT06875765
- Testing
- 11C-UCB-J PET-CT, 18F-PE2I PET-CT, MRI brain
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dyspepsia and Other Specified Disorders of Function of Stomach, Postprandial Distress Syndrome
Primary Care dySpEpsia rikkuNshiTo
Dyspepsia refers to chronic or recurrent upper gastrointestinal (GI) symptoms originating from the gastroduodenal region with a significant impact on patients' lives.
- Trial name
- PRESENT (NCT06482671)
- Testing
- Rikkunshi-to
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Urogenital Cancer, Lower Limb Lymphedema
Lymphoedema and Nocturia/Nocturnal Polyuria After Pelvic LND for Urogenital Cancer
After the treatment of urogenital cancer, a person may develop lymphoedema of the leg(s) and/ or midline region. Clinical symptoms include abnormal tissue swelling, sensation of limb heaviness, erythema, pain, and impaired limb…
- Conditions
- Urogenital Cancer, Lower Limb Lymphedema, Nocturia, Nocturnal Polyuria
- Trial name
- UroLymph (NCT05300308)
- Testing
- usual care
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy, Spastic
Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy
A randomized controlled trail will be carried out to investigate the effect of a 12-week supervised home-based progressive strength intervention in children with spastic cerebral palsy aged 5-11 years.
- Trial name
- NCT03863197
- Testing
- Progressive strength training
- Where
- 2 sites in Belgium
- Volunteers
- 49 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Intellectual Developmental Disorder, Malformations
The Belgian Genome Resource to Resolve Rare Diseases
Whole-exome (WES) or whole-genome sequencing (WGS) are recommended as first- or second-tier molecular tests for patients with developmental disorders (DD), but the clinical utility of WGS continues to be debated.
- Conditions
- Intellectual Developmental Disorder, Malformations, Dysmorphia, Developmental Delay (Disorder)
- Trial name
- BeSolveRD (NCT07051213)
- Testing
- Whole exome sequencing, Whole genome Sequencing
- Where
- Belgium
- Volunteers
- 567 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tricuspid Regurgitation (TR)
Ambulant Monitoring to Detect Hemodynamic and Electrical Impact of Severe Tricuspid Valve Regurgitation
This exploratory study aims to study the feasibility to detect early signs of disease progression in patients with severe TVR (grade ≥3/4) by monitoring electrical cardiac activity and correlating it with echocardiographic…
- Trial name
- NCT07043465
- Testing
- 14 days ambulatory rhythm monitoring
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease, OCT Angiography
Coronary Evaluation And Guided Lesion Exploration Using Photon-counting CT and Intracoronary Imaging Techniques
This study evaluates the diagnostic accuracy and limitations of photon-counting computed tomography (PCCT) in characterizing coronary plaque, with comparisons to optical coherence tomography (OCT) and intravascular ultrasound…
- Conditions
- Coronary Artery Disease, OCT Angiography, CT
- Trial name
- C-EAGLE (NCT07036770)
- Testing
- Coronary CT scan using photon-counting CT
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Perinatal Depression
Clinical and Cost-effectiveness of an Online Self-help Intervention and a Face-to-face Intervention Versus Usual Care in Mothers at Moderate Risk for Perinatal Depression
The perinatal period (pregnancy and the first postnatal year) (O'Hara \& Wisner, 2014) involves important changes and considerable challenges for parents (Milgrom \& Gemmill, 2015).
- Trial name
- MaMHI (NCT07027761)
- Testing
- Online self-help, Maternal Mental Health Intervention (MaMHI), Usual Care
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 5
This clinical study evaluates the reliability, concurrent validity, and clinical feasibility of a new method to determine leg volume, namely the Structure Sensor Scanner.
- Trial name
- EvaLymph-Leg5 (NCT07017166)
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ovarian Cancer, Fallopian Tube Cancer
European Trial on Enhanced DNA Repair Inhibition in Ovarian Cancer
This study will be performed in women with platinum-sensitive, high-grade serous, high-grade endometrioid, undifferentiated epithelial ovarian cancer, carcinosarcoma, fallopian tube or primary peritoneal cancer (proven by central…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- EUDARIO (NCT03783949)
- Testing
- Ganetespib, Niraparib, Carboplatin
- Where
- 13 sites in Austria, Belgium and 3 more
- Volunteers
- 122 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pregnancy, Epidural Analgesia, Obstetric
Intelligence and Neurodevelopmental Outcome After Prenatal Exposure to Labour Epidural Analgesia: a Sibling Matched Clinical Ambidirectional Cohort Study
In Belgium, labour epidural analgesia (LEA) has been used for decades in the vast majority of vaginal deliveries (up to 83% of deliveries).
- Trial name
- NCT07014956
- Testing
- Labour epidural analgesia
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rheumatoid Arthritis
Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-guided Dose Reduction in Patients With Rheumatoid Arthritis
The goal of this open label multicenter randomized controlled pragmatic superiority trial is to investigate the optimal treatment/tapering strategy with rituximab for patients with rheumatoid arthritis.
- Trial name
- RITUXERA (NCT06003283)
- Testing
- Rituximab
- Where
- 7 sites in Belgium
- Volunteers
- 134 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Constipation
Effect to Linaclotide on Colonic Motility
This study aim was to evaluate the effect of Linaclotide, a pharmacological treatment normally used to treat functional constipation or irritable bowel syndrome with predominant constipation, on colonic motility as assessed by…
- Trial name
- NCT06989268
- Testing
- Linaclotide 290 micrograms
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven