Clinical trials: open to volunteers, sponsored by Universitaire Ziekenhuizen KU Leuven
Peroneal Nerve Entrapment
Follow-up and Outcome of Operative Treatment With Decompressive Release Of The Peroneal Nerve
The FOOT DROP trial is a prospective, multi-center, randomized controlled trial to assess if decompressive surgery for peroneal nerve entrapment is superior to maximal conservative treatment.
- Trial name
- FOOTDROP (NCT04695834)
- Testing
- Neurolysis peroneal nerve, Maximal physiotherapy
- Where
- 18 sites in Belgium, Netherlands
- Volunteers
- 182 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Venous Disease
Outcomes of Different Treatment Options in Chronic Venous Disease
This study aims to describe conservative and invasive treatments for patients with chronic venous disease (CVD) in Belgium, and their association with clinical and patient-reported outcomes during a follow-up of 24 months.
- Trial name
- VOS (NCT06318988)
- Testing
- Radiofrequency ablation using Closure fast, Aethoxysclerol, Daflon
- Volunteers
- 2,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
ACL Injury
Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries
Currently, most patients with an anterior cruciate ligament injury undergo surgery. There is a general belief that surgical reconstruction is necessary to safely return to sports and to prevent early knee osteoarthritis or…
- Trial name
- IODA (NCT05747079)
- Testing
- Rehabilitation, Optional delayed anterior cruciate ligament reconstruction, Immediate anterior cruciate ligament reconstruction
- Where
- Belgium
- Volunteers
- 280 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer, Hereditary Diseases
UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research
UPTIDER is a prospective, interventional, non-Investigational Medicinal Product (non-IMP), non-commercial, single centre post-mortem tissue donation program for metastatic breast cancer patients or patients with a germline…
- Trial name
- UPTIDER (NCT04531696)
- Testing
- Blood draw, Post-mortem tissue collection
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Brain Injury, Traumatic Brain Injury
Connectivity and Neural Signatures of Consciousness in Unresponsive States
The CONSCIUS study is a prospective, interventional study including patients with acute brain injury and impaired consciousness implanted with intracranial electrodes.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Consciousness Disorders, Seizures
- Trial name
- CONSCIUS (NCT06426615)
- Testing
- Intracranial electrodes
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prostate Cancer, Adenocarcinoma of the Prostate
Prospective Prostate Cancer and Patient-reported Outcomes Registry
This study aims to evaluate the use of a digital solution, integrated into the electronic health record, for prospective and structured reporting of clinical and patient-reported outcomes for patients diagnosed with localized or…
- Conditions
- Prostate Cancer, Adenocarcinoma of the Prostate, Locally Advanced Prostate Carcinoma, Locally Advanced Prostate Adenocarcinoma
- Trial name
- Prosquare (NCT04694924)
- Testing
- standard of care
- Where
- 4 sites in Belgium
- Volunteers
- 5,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Failure
BIOBANK Renal Transplantation University Hospitals Leuven
This study aims to maintain a prospective biobank of human samples obtained from donors and recipients of renal allografts, including biopsy tissue, peripheral blood samples and urine samples.
- Trial name
- NCT01331668
- Where
- Belgium
- Volunteers
- 5,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cognition, Brain Tumor
Neurocognition After Radiotherapy in CNS- and Skull-base Tumors
The goal of this multicenter prospective longitudinal study is to study the long-term impact of multimodal treatment (chemotherapy, radiotherapy and surgery) in adult brain and base of skull tumors on neurocognitive functioning.
- Conditions
- Cognition, Brain Tumor, Magnetic Resonance Imaging, Meningioma
- Trial name
- NARCiS (NCT05727605)
- Testing
- Neurocognitive tests: WAIS digit span, HVLT-R, COWAT, MOCA, WAIS digit symbol substitution, TMT A&B, Stroop Color Word Test, MRI, Questionnaires: EORTC QLQ C30 & BN20, STAI, CFQ, BDI-II, BRIEF-A, FACIT-F, PSQI
- Where
- 3 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Listening Difficulties
Causes of Listening Difficulties in Children
Many children experience listening and processing difficulties (LiD), especially in background noise, despite normal hearing sensitivity. The prevalence of these problems is estimated at 0.5-1% in the general population.
- Trial name
- CLINIC (NCT06388343)
- Testing
- Evaluation of Children's Listening and Processing Skills, Multidisciplinary behavioral assessment
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Transplantation, Physical Fitness
A Home-based Exercise and Physical Activity Intervention After Liver Transplantation: Impact of Exercise Intensity
Research demonstrated that transplant recipients benefit from physical activity, but there is a gap in knowledge regarding the required intensity.
- Trial name
- PHOENIX-L (NCT06302205)
- Testing
- Physical activity
- Where
- Belgium
- Volunteers
- 147 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Urinary Bladder Neoplasms
Prospective Sample Collection for Cancer of Bladder
The goal of the Flemish Databank for Urothelial Cancer is to collect clinical and pathological data of patients treated for urothelial cancer (UC).
- Trial name
- ProCaB (NCT03973671)
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Rhinosinusitis With Nasal Polyps, Allergic Rhinitis
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected…
- Trial name
- NCT06129552
- Testing
- Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Extradural Tumor, Spinal Metastases
SBRT in the Management of Solid Spinal Metastases
Documenting efficiency of SBRT in the management of epidural spinal metastases from solid tumors
- Trial name
- NCT04863612
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prostate Cancer
Long-term Better Than Short-term ADT With Salvage RT
A randomized, multicenter, prospective PHASE II trial to assess the effect of short- versus long-term adjuvant ADT with high dose salvage radiotherapy on distant metastasis free survival in case of biochemical relapse (BR) after…
- Trial name
- LOBSTER (NCT04242017)
- Testing
- Triptoreline
- Where
- 3 sites in Belgium
- Volunteers
- 394 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epilepsy
Brain Activity in Epilepsy
Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.
- Trial name
- NCT05307146
- Testing
- macro/micro electrode recording
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Athlete Heart
Prospective Athlete's Heart Study
The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e.
- Trial name
- Pro@Heart (NCT05164328)
- Testing
- No intervention
- Where
- 4 sites in Australia, Belgium
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bladder Cancer
Prospective Collection of Samples for Urothelial Cancer of Bladder
ProCSUCaB (Prospective Collection of Samples for Urothelial Cancer of Bladder) is a monocentric, non-interventional, prospective registry that will recruit newly diagnosed intermediate- and high-risk NMIBC patients in a tertiary…
- Trial name
- ProCSUCaB (NCT04167332)
- Volunteers
- 630 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven