Clinical trials: completed, sponsored by Universitaire Ziekenhuizen KU Leuven
Mucormycosis
Mucorales PCR Screening in At-risk Hematology Patients
Patients with leukemia are treated with intensive chemotherapy and often have to undergo a stem cell transplantation which makes their immune system extremely vulnerable.
- Trial name
- MUCOPS (NCT05925660)
- Testing
- Mucorales PCR (MucorGenius, PathoNostics, Maastricht, The Netherlands)
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neutropenia, Febrile
Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia
The goal of this clinical trial is to compare a short course of antibiotics in patients in whom no bacterial infection is found with the current "golden standard": long-term antibiotic treatment in adult hematology patients who…
- Trial name
- SAFE (NCT05926063)
- Testing
- Comparison short vs extended EBAT treatment group
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Short Bowel Syndrome, Anticoagulation
Pharmacokinetics of Apixaban in Patients With Short Bowel Syndrome Requiring Long Term Parenteral Nutrition
Short bowel syndrome (SBS) is defined as a loss of function of the small intestine resulting in a malabsorptive disorder. In SBS, oral drug absorption may be altered due to extensive intestinal resection.
- Trial name
- ABSORB (NCT04344717)
- Testing
- Apixaban single dose, Apixaban steady-state
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy (CP), Typically Developing Children
The Effect of Perturbation Training on Reactive Balance in Children With Cerebral Palsy
The aim of this project was to evaluate whether perturbation training influences reflex modulation in children with spastic CP and whether changed reflex modulation leads to improved reactive balance and walking.
- Trial name
- NCT07818928
- Testing
- Balance training on a moving platform
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Overweight and Obesity, Bariatric Surgery Candidate
Protein Digestion After Bariatric Surgery in Older Adults
The goal of this clinical trial is to investigate protein digestibility after bariatric surgery. Does protein digestibility decrease after Roux-en-Y-Gastric Bypass? Does protein digestibility decrease after Sleeve Gastrectomy…
- Conditions
- Overweight and Obesity, Bariatric Surgery Candidate, Aging, Protein Malabsorption
- Trial name
- ProDigBO (NCT06076187)
- Testing
- Dual isotope protein digestibility method
- Where
- 2 sites in Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spina Bifida, Neuromuscular Diseases
Metformin in Children With Motor Deficit
Obesity with insulin resistance in the paediatric population provides an increasing challenge. Children with neurological or neuromuscular diseases are even more prone to obesity: their locomotor impairment leads to an…
- Trial name
- NCT00720161
- Testing
- Metformin
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Poor Glycemic Control, Quality of Life
Benefits of a Bolus Calculator in Pediatric Patients on Multiple Daily Insulin Injections
It it hypothesized that children and adolescents with type 1 diabetes, who are counting carbohydrates can achieve better metabolic control by concurrent use of the Accu-Chek Aviva Expert.
- Trial name
- NCT06141629
- Testing
- accu chek Aviva Expert, Accu Chek Aviva Nano
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
3D Foot Scanning and Customized 3D-Printed Foot Orthotics to Reduce Pressure on the Feet of Healthy Adults
The number of people with diabetes mellitus worldwide is increasing rapidly and is expected to rise to 439 million by 2030, or 7.7% of the total adult world population.
- Trial name
- NCT07781618
- Testing
- Foot orthotics
- Where
- Belgium
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tooth Loss and Rehabillitation
Custom Provisionalisation
Fully digital immediate implant treatment by means of fully guided implant placement and custom designed provisionalisation with a individual designed abutment and temporary PMMA crown leads to better esthetic outcomes than free…
- Trial name
- Azento (NCT07731854)
- Testing
- Fully guided implant placement, Free handed implant placement, individualised abutment + digital prepared provisional crown
- Where
- 2 sites in Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gingival Recession, Generalized
Ultrasonographic Vascular Supply
Pre-operative ultrasound enables visualization of mandibular arterial branches relevant to flap design in mucogingival surgery. This study documents the pre-and post operative course of these arteries in four CAF procedures using…
- Trial name
- NCT07727707
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mitral Valve Prolapse, Ventricular Arrythmia
Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
Mitral valve prolapse (MVP) affects up to 3% of the general population and a small subset of patients is at risk for ventricular arrhythmias.
- Trial name
- ALARM-PILOT (NCT06378996)
- Testing
- 14-day rhythm monitoring
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Foot and Ankle Arthrodesis, Foot and Ankle Osteotomy
Foot and Ankle Arthrodesis or Osteotomy With Io-Fix Type Fixation
The recovery of foot and ankle arthrodesis and osteotomy is still plagued by the problem of delayed consolidation or even pseudo-arthrosis.
- Trial name
- NCT04812353
- Testing
- Follow-up of Io-Fix type fixation
- Where
- Belgium
- Volunteers
- 208 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometriosis, Endometriosis, Rectum
Patient Reported Outcomes After Surgery for Rectal Endometriosis
To describe the difference in patient reported outcomes after conservative treatment in comparison to radical rectal surgery in patients with deep endometriosis infiltrating the rectum (up to 15cm from the anus with at least…
- Conditions
- Endometriosis, Endometriosis, Rectum, Endometriosis-related Pain, Endometriosis; Bowel
- Trial name
- PROCURE (NCT04204707)
- Testing
- PROMS
- Where
- 2 sites in Belgium, Hungary
- Volunteers
- 294 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy (CP), Typically Developing Children
Interaction Between Spasticity and the Initial Response After Balance Perturbations in Children With Spastic Cerebral Palsy
The aim of this study was to investigate the link between spasticity and the initial response after standing balance perturbations in children with spastic cerebral palsy.
- Trial name
- NCT07616193
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alveolar Bone Resorption
LPRF Block vs. DBBM in Horizontal Bone Reconstruction
split-mouth RCT. 12 patients. horizontal GBR performed. 2 grafts were compared: test was LPRF block, control was 50% autogenous bone and 50% DBBM. 25 months follow-up.
- Trial name
- NCT07584629
- Testing
- guided bone regeneration
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spastic Cerebral Palsy
Homebased (6-week) Stretching Intervention in Children With Spastic Cerebral Palsy
This study will investigate the effect of a 6-week stretching intervention, consisting of a combination of a 2-week casting period and a home-based stretching program of the plantar flexors and hamstrings, on muscle and tendon…
- Trial name
- NCT04904094
- Testing
- Casting of the lower limb and homebased stretching exercise program.
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Enhanced Recovery After Surgery, Cardiac Surgical Procedures
Audit of the Revised PACU Centric ERACS Program
A previous audit (S63843) found an association between improved compliance with these interventions and postoperative outcomes (hospital length of stay (LOS) and presence of ≥1 postoperative complication).
- Trial name
- ERACS2 (NCT06257745)
- Testing
- Compliance with ERACS guideline as described in the current ERACS guidelines from Engelman et al. 2019
- Where
- Belgium
- Volunteers
- 487 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cranial Sutures; Closure
Role of Leukocyte- and Platelet-Rich Fibrin Membranes in Endoscopic Endonasal Skull Base Reconstruction
Prospective investigation of the effectivity of L-PRF membranes for skull base reconstruction after endoscopic endonasal skull base surgery (transsphenoidal) versus classical closure techniques.
- Trial name
- NCT03910374
- Testing
- Dural closure
- Where
- 3 sites in Belgium, Spain
- Volunteers
- 220 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Head and Neck Cancer
Effect of Exercise in Head and Neck Cancer Patients
Head and neck cancers (HNC) are malignancies originating from the mucosa in the oral cavity, nasopharynx, oropharynx, hypopharynx and larynx.
- Trial name
- EffEx-HN (NCT05256238)
- Testing
- comprehensive supervised exercise program (CSEP)
- Where
- Belgium
- Volunteers
- 133 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dialysis; Complications
Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Serum Magnesium Levels
Individuals with ESKD and treated with hemodialysis have a high mortality risk. Associative studies suggest a relationship between serum magnesium concentration and mortality risk.
- Trial name
- OMAGOD-1 (NCT07565779)
- Testing
- A - Dialysate magnesium 0.75, B - Dialysate magnesium 1.00 mmol/L
- Where
- 4 sites in Belgium
- Volunteers
- 54 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven