Clinical trials: sponsored by University College, London
Obesity
APPETITE: linguAl PYY3-36 on aPpEtite and acuTe Energy InTakE
A double-blind, cross-over, placebo-controlled, proof-of-concept study using oral peptide YY3-36 solution to investigate the mechanistic role of lingual PYY in regulating appetite, energy intake and food preference in people with…
- Trial name
- APPETITE (NCT05110664)
- Testing
- PYY (3-36) Peptide, Placibo
- Volunteers
- 40 people
- Sponsor
- University College, London
Hepatic Steatosis, HIV-1-infection
Adding MAraViroc &/or METformin for Hepatic Steatosis in People Living With HIV
This is a multicentre, phase IV, randomised, open-label, trial exploring adjunctive maraviroc and/or metformin for liver steatosis over 48 weeks.
- Trial name
- MAVMET (NCT03129113)
- Testing
- Maraviroc, Metformin
- Where
- 6 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University College, London
Xerostomia, Head and Neck Neoplasms
A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer
This trial is looking at using an intra-oral electrostimulating device for the management of radiotherapy-induced dry mouth.
- Trial name
- LEONIDAS-2 (NCT02941276)
- Testing
- Active Electrostimulator device
- Volunteers
- 84 people
- Sponsor
- University College, London
Prostate Cancer Screening, Prostate Cancer
ReIMAGINE Prostate Cancer Screening
Single site study to assess the feasibility of prostate cancer screening using an invitation for a prostate MRI scan via GP practices.
- Trial name
- NCT04063566
- Testing
- Magnetic Resonance Imaging (MRI), Prostate-specific antigen (PSA) test
- Where
- United Kingdom
- Volunteers
- 309 people
- Sponsor
- University College, London
MR Image Distortion Correction, Prostate Cancer
UNDISTORT Correction of Distortions in Diffusion MRI V1.0
This is a three-year project funded by a Cancer Research UK Multidisciplinary Award and brings together a team from UCL Division of Medicine, Computer Science and University College London Hospital.
- Trial name
- UNDISTORT (NCT03151512)
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University College, London
Systemic Lupus Erythematosus, Periodontitis
Treatment of Periodontal Disease in Systemic Lupus Erythematosus
The primary objective of this study is to: Part 1 - Baseline Comparisons The primary objective of Part 1 is to: Investigate the association between SLE and a measures of vascular health (brachial artery flow-mediated dilatyation)…
- Trial name
- NCT04046172
- Testing
- supra/sub gingival root surface debridement, supra-gingival scaling and polishing
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Sjögren's Syndrome
SS-INQ Information Needs Questionnaire in Sjögren's Syndrome
Patients with some long-standing rheumatic diseases have stated that they want to be fully informed about their disease as they find it 'more scary not to know' about possible complications and consequences.
- Trial name
- SS-INQ (NCT04798911)
- Testing
- Phase 1 Observational Interviews
- Where
- United Kingdom
- Volunteers
- 243 people
- Sponsor
- University College, London
Breast Neoplasm Female
Extended Follow up of the TARGIT-A Trial
All UK patients who participated in the TARGIT-A Trial were initially treated for early breast cancer between 2000-2012. A total of 3451 patients from 33 hospitals in 11 countries participated in the trial and a comparison was…
- Trial name
- TARGIT-X (NCT03501121)
- Where
- 2 sites in United Kingdom
- Volunteers
- 714 people
- Sponsor
- University College, London
Primary Alcohol Use Disorder
Ketamine for Reduction of Alcoholic Relapse
96 recently detoxified alcoholics will be randomized to receive either 3 sessions ketamine (0.8 mg/kg IV over 45 minutes) or placebo plus manualised psychological therapy, or 3 sessions of ketamine or placebo plus simple…
- Trial name
- KARE (NCT02649231)
- Testing
- Ketamine, Psychological Therapy, Alcohol Education
- Where
- 2 sites in United Kingdom
- Volunteers
- 96 people
- Sponsor
- University College, London
Cannabis, Cannabis Intoxication
Do Adolescents and Adults Differ in Their Acute Response to Cannabis?
The acute effects of cannabis may differ between adolescents and adults. Furthermore, these effects may be tempered by the presence of cannabidiol.
- Conditions
- Cannabis, Cannabis Intoxication, Cannabis Use, Cannabis Dependence
- Trial name
- CannTeenA (NCT04851392)
- Testing
- Cannabis with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), Cannabis with THC without CBD
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University College, London
Critical Illness, Respiratory Failure
Targeted OXYgen Therapy in Critical Illness
The investigators propose to conduct a feasibility, multi-centre, randomised controlled trial of targeted oxygen therapy in adult critically ill patients receiving mechanical ventilation via an endotracheal tube as part of their…
- Trial name
- TOXYC (NCT03287466)
- Testing
- Oxygen
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Head and Neck Squamous Cell Carcinoma, Lymphoma
GlucoCEST MRI in Oncology
The roles of imaging in cancer may be divided into that of diagnosis and tumour detection, staging and assessment of response to treatment.
- Conditions
- Head and Neck Squamous Cell Carcinoma, Lymphoma, Glioma
- Trial name
- NCT03212157
- Testing
- Glucose infusion, Magnetic Resonance Imaging (MRI), FDG PET
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University College, London
Smouldering Myeloma, MGUS
Biology and Genetics of Smouldering Myeloma
Observational clinical trial recruiting Smouldering Myeloma patients (SMM) or potential SMM patients. Study involves collecting blood and bone marrow samples to determine the features of the tumour genome and BM microenvironment…
- Conditions
- Smouldering Myeloma, MGUS, Multiple Myeloma
- Trial name
- COSMOS (NCT05047107)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Diffuse Large B Cell Lymphoma
A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Trial Subjects (patients), will receive single infusions of pembrolizumab in combination with CXD101 every 3 weeks for two years or until disease progression or unacceptable toxicity develops.
- Trial name
- PLACARD (NCT03873025)
- Testing
- Pembrolizumab and CXD101
- Sponsor
- University College, London
Chronic Kidney Diseases
Assessing Bone Calcium Content in Children With Kidney Disease Treated With Two Different Medicines
This is an open label, time series trial. The trial is likely to be single centre (additional sites will only be opened if necessary) and will involve 25 children with chronic kidney disease (stage 3b, 4-5) or on dialysis.
- Trial name
- CAL-BAL (NCT04120922)
- Testing
- calcium carbonate, sevelamer carbonate
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University College, London
Dementia
SettleIN - Adjustment to Care in Dementia: An Intervention Feasibility Study v0.1
Admission into a care home for people with dementia has been linked with both positive and negative psychological outcomes for both the resident and their carers.
- Trial name
- NCT02682472
- Testing
- SettleIN - Adjustment to care programme
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Endometrial Cancer
A Parp Inhibitor (BMN 673) for Inoperable Advanced eNDometrial cAncer
A Single Arm Phase II Trial of BMN 673 for Inoperable, Advanced Endometrial Cancer With Retrospective PTEN, MSI and MRE11 Analysis PTEN= Phosphatase and tensin homolog MSI= Microsatellite instability MRE11= Double-strand break…
- Trial name
- PANDA (NCT02127151)
- Testing
- BMN 673
- Where
- 16 sites in United Kingdom
- Sponsor
- University College, London
Waldenstrom's Macroglobulinaemia
Randomised Trial in Waldenstrom's Macroglobulinaemia
The purpose of this trial is to assess tolerability and efficacy of the Bortezomib, Cyclophosphamide and Rituximab combination as initial therapy for previously untreated patients with symptomatic Waldenstrom's macroglobulinaemia.
- Trial name
- R2W (NCT01592981)
- Testing
- Bortezomib, Cyclophosphamide, Rituximab
- Where
- 30 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Intellectual Disability
Intensive Support Teams Study
About 17% of people with ID living in the community have challenging behaviour such as aggression to others or property, self-injury or hyperactivity.
- Trial name
- IST-ID (NCT03586375)
- Testing
- Intensive Support Team Care
- Where
- 16 sites in United Kingdom
- Volunteers
- 226 people
- Sponsor
- University College, London
Breast Cancer, Unilateral
MIAMI Safe Surgery for Multiple Breast Cancers
Sometimes women have more than one breast cancer in the same breast at the same time. These women are usually offered a mastectomy (removal of that breast) and breast reconstruction.
- Trial name
- MIAMI (NCT03514654)
- Testing
- Mastectomy, Therapeutic Mammoplasty
- Where
- 7 sites in United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College, London