Clinical trials: sponsored by University College, London
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Dehydration (Physiology), Thirst; Due to Deprivation of Water
Patient Controlled Fluid Administration
The purpose of the study is to determine whether participants who are dictating their own administration of IV fluid boluses in response to thirst, receive better protection from hypovolaemia and volume overload than those who…
- Conditions
- Dehydration (Physiology), Thirst; Due to Deprivation of Water, Plasma Osmolality Increased, Hypovolemia
- Trial name
- NCT03176043
- Testing
- IV Fluid Administration
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University College, London
HIV, Latent Tuberculosis
Testing for Tuberculosis in the United Kingdom HIV Infected Population
Human Immunodeficiency Virus (HIV) is the strongest individual risk factor for the reactivation of tuberculosis (TB) after previous exposure to Mycobacterium tuberculosis (MTb).
- Trial name
- NCT02712671
- Testing
- Chest radiograph, Blood interferon gamma release assay, Tuberculin skin testing (TST)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Glioblastoma
Cediranib Maleate With or Without Gefitinib in Treating Patients With Recurrent or Progressive Glioblastoma
RATIONALE: Cediranib Maleate and gefitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT01310855
- Testing
- cediranib maleate, gefitinib
- Where
- 10 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- University College, London
Ischemic Stroke
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study
Ischaemic stroke causes significant morbidity and mortality and is a leading cause of disability within an ageing United Kingdom (UK) population.
- Trial name
- RICE PAC (NCT03152799)
- Testing
- RIPC Remote Ischaemic Pre-Conditioning
- Volunteers
- 60 people
- Sponsor
- University College, London
Prostate Cancer
Magnetic Nanoparticle Thermoablation-Retention and Maintenance in the Prostate:A Phase 0 Study in Men
Men with early prostate cancer face a number of options which lie at the extremes of care. On one hand, active surveillance involves monitoring the disease and on the other, immediate treatment involves surgery or radiotherapy.
- Trial name
- MAGNABLATE I (NCT02033447)
- Testing
- Magnetic Nanoparticle Injection
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College London Hospitals
Progression of Prostate Cancer
FOcal RECurrent Assessment and Salvage Treatment
Radiotherapy is the commonest form of prostate cancer treatment in the UK. In one in four men, radiotherapy will fail to control the cancer. These men are offered hormonal treatment which has significant side effects.
- Trial name
- FORECAST (NCT01883128)
- Testing
- Whole Body MRI, Focal Salvage Therapy, MRI Targeted biopsies
- Where
- 2 sites in United Kingdom
- Volunteers
- 177 people
- Sponsor
- University College London Hospitals
PROSTATE CANCER
Prostate Cancer Genomic Heterogeneity
The purpose of this study is to carry out very detailed genetic testing on prostate cancer cells. The reason to do this is because researchers do not fully understand How prostate cancer develops Why some cancer cells spread and…
- Trial name
- PROGENY (NCT02022371)
- Testing
- Targeted biopsies of the prostate
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College London Hospitals
ST-segment Elevation Myocardial Infarction (STEMI)
Effect of Remote Ischemic Conditioning in Heart Attack Patients
New treatments are required to improve health outcomes in patients with ischemic heart disease. This is especially so in developing countries such as Mauritius in which optimal therapy for acute myocardial infarction may not be…
- Trial name
- ERIC-LYSIS (NCT02197117)
- Testing
- Remote ischemic conditioning, Control
- Where
- 5 sites in Mauritius
- Volunteers
- 519 people
- Sponsor
- University College, London
Epilepsy
Ketogenic Diet in Infants With Epilepsy (KIWE)
Epilepsy, a condition where individuals are prone to recurrent epileptic seizures, is the most common chronic neurological disorder in children.
- Trial name
- KIWE (NCT02205931)
- Testing
- Ketogenic diet, Antiepileptic drug therapy
- Where
- 11 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University College, London
Influenza, Human, Respiratory Syncytial Virus Infections
Specific Respiratory Infections as Triggers of Acute Medical Events
This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and…
- Conditions
- Influenza, Human, Respiratory Syncytial Virus Infections, Parainfluenza, Rhinovirus
- Trial name
- NCT02984280
- Where
- United Kingdom
- Volunteers
- 787,000 people
- Sponsor
- University College, London
Early-Stage Breast Carcinoma
PICTURE Breast XS: Patient Information Combined for Local Therapy oUtcome Assessment in bREast Cancer - Cross-sectional
This project which is fully funded by the European Union FP7 Program is designed to pull together all the information we obtain from scans and x-rays to design a personalised 3-D digital model of each patient, their anatomy and…
- Trial name
- PICTURE XS (NCT02310984)
- Where
- 3 sites in Netherlands, Portugal and 1 more
- Volunteers
- 222 people
- Sponsor
- University College, London
Breast Neoplasms
PICTURE Breast L: Patient Information Combined for Local Therapy oUtcome Assessment in bREast Cancer - Longitudinal
This project which is fully funded by the European Union FP7 Program is designed to pull together all the information we obtain from scans and x-rays to design a personalised 3-D digital model of each patient, their anatomy and…
- Trial name
- PICTURE L (NCT02341820)
- Where
- 3 sites in Netherlands, Portugal and 1 more
- Volunteers
- 83 people
- Sponsor
- University College, London
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Severe Obsessive Compulsive Disorder
The overarching aim is to compare the effects of ventral capsule/ventral striatum (VC/VS) and subthalamic nucleus (STN) deep brain stimulation (DBS) in the same participants.
- Trial name
- NCT02655926
- Testing
- Deep Brain Stimulation
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Stress, Psychological, Depression
The Efficacy of a Mobile Application for Treating Depression and Anxiety Symptoms
This was a 12-week, parallel randomised controlled trial, including a 6-week follow-up. The trial compared a group of university students (N = 84) receiving a mobile CBT application intervention ("Feel Stress Free") to a…
- Conditions
- Stress, Psychological, Depression, Anxiety
- Trial name
- NCT03032952
- Testing
- "Feel Stress Free" mobile application
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University College, London
Emotional Difficulties
A Feasibility Trial of Power Up
There is an increasing demand for digital tools to empower young people with mental health difficulties (NHS England, 2015). Digital information, advice and mood tracking tools are increasingly being used to support child mental…
- Trial name
- NCT02987608
- Testing
- Power Up
- Where
- 3 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- University College, London
Parkinson's Disease
Trial of Exenatide for Parkinson's Disease
This study is a clinical trial in patients with Parkinson's disease, of a drug called Exenatide which is already licensed for the treatment of patients with Type 2 Diabetes.
- Trial name
- EXENATIDE-PD (NCT01971242)
- Testing
- Exenatide
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Chronic Lymphocytic Leukemia
Pilot Study to Establish Safety & Efficacy of a Combination of Dexamethasone and Lenalidomide in Patients With Relapsed or Refractory Chronic Lymphocytic Leukaemia (CLL)
The purpose of this study is to establish the safety and efficacy of a combination of dexamethasone and lenalidomide (Revlimid®) (D+L) in subjects with relapsed or refractory CLL who have failed or are unable to tolerate standard…
- Trial name
- LenD (NCT01459211)
- Testing
- Lenalidomide & Dexamethasone
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Congenital Heart Disease (CHD)
National Congenital Heart Disease Audit
The National Institute of Cardiovascular Outcomes Research (NICOR) collects data and produces analysis to enable hospitals and healthcare improvement bodies to monitor and improve the quality of care and outcomes of…
- Trial name
- NCT02303535
- Testing
- Cardiac Surgery, Therapeutic cardiac catheterisations procedures
- Where
- 10 sites in United Kingdom
- Volunteers
- 120,000 people
- Sponsor
- University College, London
Stroke, Brain Injuries
Brain Mechanisms Underlying Reading Improvement in Central Alexia
Central alexia is a common reading disorder caused by stroke. Patients with central alexia (CA) are slow to read and make frequent errors, and have additional problems with their spoken language. This study has 3 aims: 1.
- Conditions
- Stroke, Brain Injuries, Aphasia
- Trial name
- NCT02062619
- Testing
- Computer-based behavioural word reading therapy, Real tDCS
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London