Clinical trials: open to volunteers, sponsored by University College, London
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity (MARES3)
The investigators aim to investigate how individuals attending primary healthcare (PHC) services in Brazil for treatment of non-communicable diseases (NCDs), identified there as having abnormal spirometry or as being at high risk…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry (PRISM)
- Trial name
- NCT07134855
- Where
- 2 sites in Brazil
- Volunteers
- 473 people
- Sponsor
- University College, London
Endometrial Cancer
pReOperative Dostarlimab and Novel Therapies in EndOmetrial Cancer
RODEO is a window of opportunity trial using dostarlimab in patients with newly diagnosed high-risk (stage 2-4) endometrial cancer who are suitable for primary surgery.
- Trial name
- RODEO (NCT07115927)
- Testing
- Dostarlimab
- Volunteers
- 40 people
- Sponsor
- University College, London
Dementia
BELIDE: Better Living With Non-memory-led Dementia
Around 48 million people worldwide 1 live with dementia, of whom 3.9 million start with symptoms before the age of 65 (young-onset dementia).
- Trial name
- BELIDE (NCT06241287)
- Testing
- Better Living with Non-memory led Dementia programme, Waiting list
- Where
- United Kingdom
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity
The investigators aim to evaluate whether it is feasible for healthcare professionals to implement a case-finding tool to identify individuals at high risk for chronic respiratory diseases (CRDs) during routine care for…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry
- Trial name
- MARES2 (NCT07093021)
- Where
- 2 sites in Brazil
- Volunteers
- 1,000 people
- Sponsor
- University College, London
Chronic Migraine, Headache, Refractory Migraine
Occipital Nerve Stimulation in Chronic Migraine
The goal of this clinical trial is to compare two different types of occipital nerve stimulation (BurstDR (dorsal root) microdosing versus Tonic) in chronic refractory migraine.
- Trial name
- NCT07087678
- Testing
- Prodigy internal pulse generator occipital nerve stimulator
- Volunteers
- 40 people
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multi-Morbidity
The investigators aim to make it easier to find people with undiagnosed long-term lung health problems (such as asthma, and chronic obstructive pulmonary disease, COPD, collectively called 'Chronic Respiratory Diseases', CRDs)…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry
- Trial name
- MARES1 (NCT07050823)
- Where
- 2 sites in Brazil
- Volunteers
- 859 people
- Sponsor
- University College, London
Stroke, Mild Cognitive Impairment (MCI)
Telerehabilitation Decision Support System: Pilot Testing Protocol
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment (MCI), Vestibular Disease, Long Covid-19
- Trial name
- TeleRehab DSS (NCT07079787)
- Testing
- TeleRehab DSS Pilot Test
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 30 people
- Sponsor
- University College, London
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Stroke, Mild Cognitive Impairment
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment, Vestibular Diseases, Long Covid19
- Trial name
- TeleRehab DSS (NCT06534164)
- Testing
- Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 460 people
- Sponsor
- University College, London
Unicompartmental Knee Replacement, Osteo Arthritis Knee
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control.
- Conditions
- Unicompartmental Knee Replacement, Osteo Arthritis Knee, Surgery
- Trial name
- NCT04095637
- Testing
- Medial knee arthroplasty
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University College, London
Premature Ventricular Complexes, Ventricular Tachycardia (VT)
Transcutaneous Vagus Nerve Stimulation for Ventricular Arrhythmias
Ventricular arrhythmias are abnormal heart rhythms that arise from the bottom chambers of the heart. They can cause debilitating symptoms when they occur intermittently (these are called premature ventricular ectopics or PVCs)…
- Conditions
- Premature Ventricular Complexes, Ventricular Tachycardia (VT), Ventricular Arrhythmias
- Trial name
- TREAT-VT (NCT07026695)
- Testing
- transcutaenous vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University College, London
Tuberculosis (TB)
PRecision biomArker-Guided MAnagement of TuberculosIs Contacts: a Discrete Choice Experiment
This study is part of a broader programme of work to develop and pilot a randomised-controlled trial of new tests to identify people who will benefit most from preventive treatment for tuberculosis (TB).
- Trial name
- PRAGMATIC-DCE (NCT07024836)
- Where
- United Kingdom
- Volunteers
- 430 people
- Sponsor
- University College, London
Bariatric Surgery Candidate, Obesity
The Effect of Exercise in Patients Awaiting Bariatric Surgery
The aim of this project is to understand the impact of a four week preoperative exercise programme on fitness and metabolic rate and weight before surgery.
- Trial name
- BariPrehab (NCT05235945)
- Testing
- Online exercise intervention
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London
Parkinson Disease
Ambroxol to Slow Progression in Parkinson Disease
This is a UK only clinical trial in patients with Parkinson's disease (PD) of a drug called ambroxol hydrochloride, which is an already licensed drug for the treatment of respiratory conditions (such as a common cold) in many…
- Trial name
- ASPro-PD (NCT05778617)
- Testing
- Ambroxol Hydrochloride (420mg)
- Where
- 15 sites in United Kingdom
- Volunteers
- 330 people
- Sponsor
- University College, London
Mantle Cell Lymphoma
Zanubrutinib Plus Rituximab for Patients With Indolent Mantle Cell Lymphoma
Phase II, multicentre, randomised, open-label study to assess the benefit of early intervention with fixed duration, time-limited zanubrutinib-rituximab in indolent mantle cell lymphoma (MCL)
- Trial name
- ZEBRA (NCT05635162)
- Testing
- Zanubrutinib, Rituximab
- Where
- 13 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Anorexia Nervosa
Online Imaginal Exposure Therapy for Eating Disorders Trial
The goal of this clinical trial is to learn if an imaginal exposure intervention first conducted by Levinson and colleagues (2020) can produce similar promising results in individuals with anorexia on the waiting list of an NHS…
- Trial name
- NCT06818695
- Testing
- Imaginal Exposure for Anorexia Nervosa, Treatment as Usual (TAU)
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- University College, London
Brain Tumor
The Use of 5-ALA in Paediatric Patients With High Grade Brain Tumours
The aim of the study is to examine the safety and feasibility of using 5-ALA in children who have MRI scans showing an aggressive looking brain tumour.
- Trial name
- P5A (NCT06678867)
- Testing
- 5-ALA (Gliolan)
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis
STI Prophylaxis and Emergence of Antimicrobial Resistance
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted…
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis, Antibiotic Resistance, Bacterial, Microbiome
- Trial name
- SPEAR (NCT06778083)
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University College, London
Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom
FECD-TRACE is an integral component of a large research program dedicated to Fuchs Endothelial Corneal Dystrophy (FECD) in the United Kingdom.
- Conditions
- Fuchs Dystrophy, Fuchs' Endothelial Dystrophy, Fuchs' Endothelial Corneal Dystrophy of Bilateral Eyes, Corneal Dystrophy Fuchs
- Trial name
- FECD-TRACE (NCT06881771)
- Testing
- Clinical phenotyping, CTG18.1 Expansion Status Genotyping
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Spinal Cord Injuries, Neuromodulation
Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury
The investigators will recruit up to 20 volunteers with chronic, supra-sacral SCI. Following screening, eligible participants will enter 'Phase I', they will complete baseline outcome measures and then have the epidural spinal…
- Conditions
- Spinal Cord Injuries, Neuromodulation, Neurogenic Bladder, Neurogenic Bowel
- Trial name
- ImPRESS (NCT06515223)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London