Clinical trials: completed, sponsored by University Health Network, Toronto
Gynecologic Cancer
Evaluation of a Brachytherapy Discharge Education Program to Improve Patient Care
Although brachytherapy is an effective treatment modality for gynecological cancer, a significant proportion of patients develop late treatment-related vaginal toxicity, negatively impacting their quality of life and limiting…
- Trial name
- BrachDEP (NCT04707937)
- Testing
- Online education, Regular standard of care education
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Heart Failure, Cardiotoxicity
The Harmonized Interventions to Maintain Health Via Appropriate Risk Factor Modification and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Pilot Study
Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in pediatric, adolescent and young adult (AYA) cancer survivors (hereafter referred to as PAYA-CS).
- Conditions
- Heart Failure, Cardiotoxicity, Cancer
- Trial name
- HIMALAYAS-P (NCT04598646)
- Testing
- Cardio-oncology Rehabilitation (CORE), Support
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Retroperitoneal Sarcoma
The PET- Retroperitoneal Sarcoma Study
Retroperitoneal sarcoma(RPS) is a rare cancer that is difficult to cure as it typically presents as a very large abdominal mass, and complete removal with clear margins is challenging .
- Trial name
- PET-RPS (NCT04224948)
- Testing
- PET MRI scan
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University Health Network, Toronto
Oropharynx Cancer
Study of Lymphatic Drainage Mapping in Oropharyngeal Cancers
The purpose of the study is to see how practical it is to inject a radiotracer called 99m-Technetium Sulfur Colloid around the tumors for the imaging of patients with oropharyngeal cancer.
- Trial name
- NCT05055206
- Testing
- SPECT-CT
- Where
- 4 sites in Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Carcinoma, Pancreatic Ductal
Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment Selection
Researchers are looking for better ways of understanding and treating pancreatic cancer. The purpose of this study is to see how useful it is to look for changes and characteristics in your genes (molecules that contain…
- Trial name
- COMPASS (NCT02750657)
- Testing
- Molecular Profiling
- Where
- 4 sites in Canada
- Volunteers
- 332 people
- Sponsor
- University Health Network, Toronto
Epilepsy, Anxiety Disorders
Evaluating the Impact of Virtual Reality Exposure Therapy on Epilepsy/Seizure-Specific Interictal Anxiety
The purpose of this randomized control trial is to evaluate the impact of Virtual Reality (VR) Exposure Therapy (ET) on people with epilepsy who experience epilepsy/seizure-specific (ES) interictal anxiety.
- Trial name
- AnxEMU (NCT06028945)
- Testing
- HMD: Virtual Reality Exposure Therapy, HMD: Neutral Game
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder
This study will examine whether semaglutide may improve cognitive function in individuals with major depressive disorder (MDD).
- Trial name
- NCT04466345
- Testing
- Semaglutide
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University Health Network, Toronto
Pulmonary Disease, Chronic Obstructive
Cognitive and Physical Training in Patients With Chronic Obstructive Pulmonary Disease Patients
Cognitive and physical function impairments are common in patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Research has shown that cognitive and physical exercise training may be a beneficial strategy to…
- Trial name
- NCT05140226
- Testing
- Physical Training, Cognitive-Physical Training
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Postconcussion Syndrome, Mild Traumatic Brain Injury
Effectiveness of Rehabilitation in Adults Suffering From Persistent Concussion Symptoms
Protocol Summary The present study was developed to better understand the effects and benefits of individualizing rehabilitative treatments based on subgroup classifications determined by a standardized clinical examination.
- Trial name
- NCT06069700
- Testing
- Non-pharmacological Individualized rehabilitative therapy, Non-pharmacological Usual care therapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Eating Behaviors
Mindfulness-Based Eating Awareness Training for Post-bariatric Surgery Patients
The goal of this clinical trial was to see if learning and practicing mindful eating in a group was helpful for people who had bariatric surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT07131332
- Testing
- Mindful eating group
- Volunteers
- 45 people
- Sponsor
- University Health Network, Toronto
Lungcancer
A Phase I/Ib Study of MEK162, a MEK Inhibitor, in Combination With Carboplatin and Pemetrexed in Patients With Non-squamous Carcinoma of the Lung
MEK162 has shown significant inhibition of tumor growth as a single agent in NSCLC xenograft models in mice and human cancer cells in vitro, which have KRAS and/or other mutations.
- Trial name
- MEK162 (NCT02185690)
- Testing
- Binimetinib, Pemetrexed, Carboplatin
- Where
- 4 sites in Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
Cerebral Palsy (CP)
FES Implementation Pediatrics
Physical rehabilitation interventions that promote activity-dependent neuroplasticity are desired for children with CP as this will result in improved motor skill and function.
- Trial name
- NCT06689007
- Testing
- Implementation Intervention
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Leukemia, Acute
Emotion and Symptom-focused Engagement for Caregivers (EASE-CG) Pilot Study
The purpose of this study is to test the feasibility and acceptability of an adapted psychosocial intervention, called Emotion and Symptom-focused Engagement for Caregivers (EASE-CG), to reduce traumatic stress symptoms and other…
- Trial name
- EASE-CG (NCT05236296)
- Testing
- EASE-CG
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Healthcare Worker, Covid19
A Research Platform to Screen Healthcare Workers- Coordinated Approach to Pandemic Trials of COVID-19
Recent studies have shown that some individuals may be asymptomatic but continue to shed the COVID-19 virus. These individuals may represent a population that can unknowingly transmit the virus.
- Trial name
- RESPECT (NCT04574765)
- Testing
- Nasopharyngeal swab, Questionnaire collection (CITF), Optional blood collection
- Where
- Canada
- Volunteers
- 7,373 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Neoplasm, Prostate
Detection of Clinically Significant Prostate Cancer With 18F-DCFPyL PET/MR
Background: Currently, patients suspected of having prostate cancer undergo ultrasound-guided systematic biopsies of the prostate.
- Trial name
- PSMA-DOCS (NCT03149861)
- Testing
- PET/MR-ultrasound guided Fusion biopsy, Systemic TRUS guided biopsy
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
An Impact Assessment of a Culturally Tailored Online Psychosocial Program for Chinese Immigrant Women With Breast Cancer
The purpose of the study is to evaluate the effectiveness of an online psychosocial self-help program for Chinese immigrant women with breast cancer, by comparing Chinese immigrant women who receive the online psychosocial…
- Trial name
- NCT04656353
- Testing
- Intervention Arm, Control Group
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Gynecologic Cancer
Risk Stratified Multidisciplinary Ambulatory Management of Malignant Bowel Obstruction in Gynecological Cancers
Management of Malignant Bowel Obstruction (MBO) in Patients with Advanced Gynecological Cancers
- Trial name
- MAMBO (NCT03260647)
- Testing
- Management algorithm for Malignant Bowel Obstruction
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University Health Network, Toronto
Lymphoma, Non-Hodgkin's
Obinutuzumab in Combination With GDP Chemotherapy in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
This is a pilot study to determine the overall survival rate and toxicities of obinutuzumab given with GDP chemotherapy for relapsed or refractory CD20+ aggressive non-Hodgkin lymphoma.
- Trial name
- NCT02750670
- Testing
- Obinutuzumab, Gemcitabine, Dexamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Soft Tissue Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST)
A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients
This is a phase 1, open-label, single centre study of investigational drug selinexor in participants with soft tissue sarcomas that cannot be treated with standard therapies.
- Conditions
- Soft Tissue Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST), Leiomyosarcoma, Endometrial Stromal Sarcoma
- Trial name
- NCT04811196
- Testing
- Selinexor
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes Mellitus, Heart Failure
ERtugliflozin triAl in DIabetes With Preserved or Reduced ejeCtion FrAcTion mEchanistic Evaluation in Heart Failure
This study aims to elucidate the mechanisms whereby the SGLT2i "ertugliflozin" modifies cardiorenal interactions that regulate fluid volume and neurohormonal activation in patients with type 2 diabetes and heart failure (T2D-HF).
- Trial name
- ERADICATE-HF (NCT03416270)
- Testing
- Ertugliflozin
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto