Clinical trials: open to volunteers, sponsored by University Health Network, Toronto
Lung Cancer
Ex-Vivo COF Study for Lung Cancer Observation
Accessing nodules located in the most outer part of the lung is challenging. Tissue that will be removed from the lung will be used to see if we can reach and see the nodule with a very small camera.
- Trial name
- NCT04534413
- Testing
- composite optical fiberscope (COF)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Peritoneal Dialysis Complication, End Stage Kidney Disease
meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis
The primary aim of this study is to determine the safety and mechanisms of SGLT2 inhibition in individuals on peritoneal dialysis (PD) with residual kidney function (RKF).
- Conditions
- Peritoneal Dialysis Complication, End Stage Kidney Disease, Sodium-glucose Co-transporter-2 Inhibitors, Kidney Dysfunction
- Trial name
- CANARY (NCT05715814)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Kidney Transplant Recipients
The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients
The study aims to determine the short-term efficacy, mechanisms and safety of 12 weeks of dapagliflozin and semaglutide combination therapy in 20 KTR, with and without T2D.
- Trial name
- HALLMARK (NCT05938712)
- Testing
- Dapagliflozin 10 MG, Semaglutide, 1.0 mg/mL
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Suspected Sarcoidosis
Comparing Menghini-type Needle and Franseen-type Needle in EBUS-TBNA for Sarcoidosis
This randomized pilot clinical trial aims to examine whether sample collection with Franseen-type needles are effective for the diagnosis of sarcoidosis, as defined by improved sample quality for pathological diagnosis compared…
- Trial name
- NCT06220526
- Testing
- endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University Health Network, Toronto
Chronic Pain, Opioid Use
Reducing Opioid Use for Chronic Pain Patients Following Surgery
Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use.
- Conditions
- Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
- Trial name
- RECOUP (NCT03675386)
- Testing
- Interventional Group, Control Intervention
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Positron Emission Mammography and Liquid Biopsy in Women With High-risk Breast Screenings
The goal of this research study is to evaluate the performance of two experimental tests, namely Liquid Biopsy and Positron Emission Mammography (PEM) in women at high risk of breast cancer.
- Trial name
- NCT06268405
- Testing
- Liquid Biopsy, Positron Emission Mammography (PEM)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Patient Education, Radiotherapy
Virtual Vs Telephone Education in Radiotherapy
The goal of this clinical trial is to compare whether the use of videoconferencing in breast cancer patients undergoing radiotherapy is better for pre-treatment education than telephone calls.
- Trial name
- VIPER-RT (NCT07255196)
- Testing
- Videoconferencing Software for Pre-Treatment Education
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University Health Network, Toronto
Oncology
STEP2 vs. Routine Early Palliative Care: Randomized Noninferiority Trial
Palliative care aims to improve quality of life for people with advanced illness, and early palliative care (EPC) has been shown to benefit patients with late-stage cancer.
- Trial name
- STEP2 RNT (NCT07446660)
- Testing
- Virtual and in-person Symptom screening with Targeted Early Palliative care (STEP2), Early Palliative Care (EPC)
- Where
- Canada
- Volunteers
- 652 people
- Sponsor
- University Health Network, Toronto
Diffuse Large B Cell Lymphoma (DLBCL)
Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)
This is a phase ll study of participants with untreated diffuse large B Cell lymphoma (DLBCL).
- Trial name
- GRAIL (NCT06050694)
- Testing
- glofitamab
- Where
- 3 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Lung Cancer Non-Small Cell Cancer (NSCLC), Lung Cancer Small Cell Lung Cancer (SCLC)
A Lay Navigation Intervention for Patients With Lung Cancer
Background: In Canada, lung cancer accounts for approximately 25% of cancer deaths each year. There are also known sociodemographic and racial inequities in the diagnosis and treatment of lung cancer.
- Conditions
- Lung Cancer Non-Small Cell Cancer (NSCLC), Lung Cancer Small Cell Lung Cancer (SCLC), Patient Navigation
- Trial name
- NCT07548788
- Testing
- Care & Connect
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Chronic Myeloid Leukemia (CML) in
ASCiminib, With or Without Dasatinib Combination, as a 2nd-Line Therapy to ADVANCE the Treatment for Chronic Myelogenous Leukemia in Chronic Phase (ASC2ADVANCE)
This study is testing a new way to treat people with a type of blood cancer called chronic myeloid leukemia (CML) in chronic phase.
- Trial name
- NCT07538401
- Testing
- No high risk mutation, High Risk Mutation
- Volunteers
- 45 people
- Sponsor
- University Health Network, Toronto
Fabry Disease
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI
This study will evaluate whether cardiac MRI T1 and T2 mapping improves our ability to detect early abnormalities in the heart in patients with Fabry disease and identify patients at increase risk of adverse events.
- Trial name
- FIESTA-MRI (NCT04856059)
- Testing
- Cardiac MRI, ECG/Holter and Blood Biomarkers
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Locally Advanced Pancreatic Adenocarcinoma
A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment
The goal of this clinical trial is to test the effect of high-dose radiation therapy after initial chemotherapy in patients with locally advanced pancreatic cancer.
- Trial name
- ABLATE (NCT06453486)
- Testing
- High dose radiation therapy
- Where
- 2 sites in Canada
- Volunteers
- 43 people
- Sponsor
- University Health Network, Toronto
Cancer
Hypersight and Ethos In Pediatric Radiotherapy
This is a single-center, prospective pilot study evaluating the utility of HyperSight CBCT imaging and Ethos adaptive radiation planning in pediatric patients receiving radiation therapy for non-cranial tumors.
- Trial name
- Peds Ethos (NCT07528547)
- Testing
- HyperSight CBCT scans
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Bone Metastases
EXercise Enhancement After RadioTherapy for Bone Metastases
The purpose of this study is to evaluate the safety, feasibility, and acceptability of a structured, supervised exercise program combined with standard palliative radiotherapy for patients with painful non-spine bone metastases…
- Trial name
- EXERT-BM (NCT06470503)
- Testing
- Exercise Program
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Inspiratory Muscle Training
Inspiratory Muscle Training in Lung Transplant Candidates
Recovery after lung transplantation (LTx) may be complicated by prolonged mechanical ventilation (MV) and protracted intensive care unit (ICU) stay leading to immobilization and impaired health-related quality of life (HRQoL).
- Trial name
- NCT06370832
- Testing
- IMT and exercise training group
- Where
- 4 sites in Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy for Prostate Cancer
This is a Phase II prospective single-arm trial that is recruiting 80 participants from patients that have biochemical failure after radical prostatectomy with local or regional recurrence proven by PSMA PET.
- Trial name
- MIDAS-Prostate (NCT05328505)
- Testing
- Image-guided Radiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Prostate Metastases
Consolidative Prostate Radiotherapy in Metastatic Prostate Cancer
This is a prospective, randomized phase II trial investigating if radiation treatment delivered every other day for 2 weeks has the same side effects as radiation treatment delivered once weekly for 6 weeks.
- Trial name
- CONSORT-PC (NCT05656794)
- Testing
- Radiotherapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Stroke
Stimulating Postural Control to Augment Rehabilitation After Cerebral Stroke (SPARC): a Pilot Trial
People living with stroke have a high risk of falling and this risk increases as mobility improves over the first year post-stroke. Despite the high number of falls, there is a lack of interventions to prevent falls after stroke.
- Trial name
- NCT06987682
- Testing
- Balance training
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University Health Network, Toronto
Cytomegalovirus (CMV) Infection, Kidney Transplant Recipient
Renal Ex Vivo SYN002 Perfusion to Eliminate CMV Transmission
Donor organs often carry latent Cytomegalovirus (CMV) infection that may be transmitted to the recipient. The goal of this clinical trial is to determine the safety of SYN002 treatment during Ex-Vivo Organ Perfusion (EVOP) in…
- Trial name
- RESPECT-CMV (NCT07488481)
- Testing
- SYN002
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto