Clinical trials: sponsored by University Health Network, Toronto
Bone Marrow Transplant
Pneumonia Vaccine in Bone Marrow Transplant Recipients: Usefulness of Donor Vaccination
Streptococcus pneumoniae, also known as Pneumococcus, is a common cause of pneumonia in transplant patients. There has been a vaccine available for this infection called Pneumovax.
- Trial name
- NCT00143780
- Testing
- The polysaccharide vaccine used is Pneumovax (Merck vaccines), The conjugate vaccine used is Prevnar (Wyeth-Ayerst vaccines)
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Transplant
Clinical Utility of Monitoring for Human Herpesvirus-6 (HHV-6) and Human Herpesvirus-7 (HHV-7) After Liver Transplant
Human herpesvirus-6 (HHV-6) and -7 (HHV-7) infections are common after transplantation. Such infections may predispose transplant patients to other infections, contribute to a recurrence of hepatitis C virus, and affect rejection…
- Trial name
- NCT00242099
- Testing
- Monitoring - blood samples drawn to test for HHV-6 and HHV-7
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University Health Network, Toronto
Chronic Liver Disease, Liver Transplantation
Comparison of Quantiferon-TB Gold Assay With Tuberculin Skin Testing in Patients With Chronic Liver Disease
The purpose of the study is to estimate the usefulness of the QuantiFERON®-TB Gold test for the diagnosis of latent tuberculosis infection in liver transplant candidates by correlating the test results with risk factors for LTBI
- Conditions
- Chronic Liver Disease, Liver Transplantation, Tuberculosis
- Trial name
- NCT00402402
- Testing
- Tuberculin skin test, Quantiferon-TB Gold assay
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Lung Transplantation, Influenza Vaccines
Improving the Humoral Response to Influenza Vaccine in Lung Transplant Recipients by an Intradermal Strategy
The purpose of this study is to test the specific humoral response after an intramuscular and intradermal influenza vaccination in lung transplant recipients
- Trial name
- NCT00402805
- Testing
- Trivalent Inactivated Influenza Vaccine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Transplant
Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00436384
- Testing
- Monitoring-blood samples drawn for CMV testing
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Hearing Loss, Ototoxicity
Does Aspirin Have a Protective Role Against Chemotherapeutically Induced Ototoxicity?
Aspirin (ASA) has been shown, in an animal model, to attenuate the ototoxic properties of cisplatin. The researchers plan to investigate this in patients undergoing cisplatin chemotherapy.
- Trial name
- NCT00578760
- Testing
- aspirin
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- University Health Network, Toronto
Focal Hand Dystonia, Musician's Dystonia
Somatosensory Processing in Focal Hand Dystonia
Patients with focal dystonia experience uncontrollable movements of the hand during certain types of skilled movements. Though the origin of the disorder is not fully understood, it is thought that brain areas involved in moving…
- Conditions
- Focal Hand Dystonia, Musician's Dystonia, Writer's Cramp, Dystonic Cramp
- Trial name
- NCT00579033
- Testing
- Tactile training + rTMS
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Spine Surgery
Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery
Spinal fusion surgery can be associated with significant blood loss requiring allogeneic blood transfusion. Tranexamic acid is a synthetic amino acid with antifibrinolytic action that has been shown to reduce perioperative blood…
- Trial name
- NCT00444470
- Testing
- Tranexamic acid
- Where
- 3 sites in Canada
- Volunteers
- 151 people
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes, Hypercholesterolemia
The Anti-Diabetic and Cholesterol-Lowering Effects of Cinnamon and Cassia Bark
Introduction: According to the World Health Organization (WHO), approximately 150 million people worldwide have type 2 diabetes. Common and cassia cinnamon have been reported to have anti-diabetic and lipid-lowering effects.
- Trial name
- NCT00479973
- Testing
- Cinnamonforce
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Breast Study to Determine the Ability of Non-Invasive Optical Transillumination Spectroscopy to Predict Breast Density.
The purpose of this study is to learn more about the application of transillumination measurements in the determination of breast cancer risk.
- Trial name
- NCT00188682
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Breast Cancer
Psychosocial Study on Breast Cancer Risk Assessment
The proposed pilot study is part of the design and development process of a final questionnaire that aims to gain insight on factors that influences acceptance and adoption of breast cancer risk assessment in women.
- Trial name
- NCT00234715
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Parkinson's Disease
Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease
A phase II double blind trial to evaluate the effects of the AMPA, glutamte antagonist, topiramate on levodopa-induced dyskinesia in Parkinson's disease
- Trial name
- NCT00296959
- Testing
- topiramate (drug)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Glaucoma
Ocular Blood Flow in Early Glaucoma Patients Before and After Treatment With Dorzolamide
Impaired ocular blood flow is an important risk factor in the pathogenesis of primary open angle glaucoma (POAG). A few studies suggest that topical dorzolamide 2% may increase optic nerve perfusion.
- Trial name
- NCT00152932
- Testing
- Dorzolamide 2% drops, HRF and CLBF
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Thoracic Surgery
A Clinical Comparison of Three Bronchial Blockers for One-Lung Ventilation in Thoracic Surgery
This is a clinical trial comparing surgical conditions during one-lung ventilation with three different bronchial blockers or with double-lumen endobronchial tubes.
- Trial name
- NCT00188916
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Cardiovascular Disease
CVD Risk Reduction Trial
The purpose of this study is to provide lifestyle counselling for protective health behavior (exercise, diet, smoking cessation) to small groups (6-8 subjects) via teleconference.
- Trial name
- COHRT (NCT00473785)
- Testing
- Group-based motivational interviewing, Individual CVD-risk factor feedback, Education for protective health behavior change
- Where
- 3 sites in Canada
- Volunteers
- 827 people
- Sponsor
- University Health Network, Toronto
Systemic Lupus Erythematosus
Study of Methotrexate in Lupus Erythematosus
The treatment of systemic lupus erythematosus (SLE) has been aimed at decreasing mortality and morbidity because the etiology of the disease is unknown.
- Trial name
- SMILE (NCT00470522)
- Testing
- Methotrexate and folic acid
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- University Health Network, Toronto
Acute Dyspnoea
Comparison of CXR and MnDCT
A comparison of chest x-ray (CXR) and Minimum dose CT (MnDCT) in the acutely ill patient. The hypothesis is that MnDCT is more sensitive than CXR in the detection of acute findings in the acutely ill patient.
- Trial name
- NCT00188435
- Testing
- Minimum Dose CT
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Lung Cancer
Minimum Dose CT Post Lung Biopsy
The aim is to evaluate whether Minimum Dose CT (MnDCT) is useful in the management of patients post Lung Biopsy
- Trial name
- NCT00188162
- Testing
- CT
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Lung Nodules
Pneumothorax Post CT Lung Biopsy
A CT scan is performed after a lung biopsy in order to detect a Pneumothorax. We postulate that CT is more useful than chest radiography
- Trial name
- NCT00188409
- Testing
- CT scan
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Soft Tissue Sarcoma
Study of Low Dose CT in Sarcoma Patients
The primary outcome of this study is the detection of lung metastases comparing Low dose CT (LDCT) and Minimum dose CT (MnDCT) with CXR. Hypothesis 1.
- Trial name
- NCT00188422
- Testing
- low dose CT
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto