Clinical trials: sponsored by University Health Network, Toronto
Insulin Resistance
Regulation of Endogenous Glucose Production by Brain Insulin Action in Insulin Resistance
It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production.
- Trial name
- NI EGP highBMI (NCT03383822)
- Testing
- Intranasal insulin
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Regional Anesthesia
Spinal Anesthesia in Patients With Poorly-palpable Surface Landmarks
Anesthesia trainees can perform spinal anesthesia in patients who have poorly-palpable surface landmarks with fewer needle passes using an ultrasound-guided technique compared to the conventional surface landmark-guided technique.
- Trial name
- NCT03377764
- Testing
- Landmark Technique Control group, Neuroaxial block using Ultrasound Guidance
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University Health Network, Toronto
Upper Limb Surgery, Iliac Crest Bone Harvest
Transversalis Fascial Plane Nerve Block in Iliac Crest Bone Graft
Hand or wrist surgery often requires the use of bony material in order to accomplish any associated reconstructive aspects required for the surgery.
- Trial name
- NCT01133730
- Testing
- Active treatment
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Treating Major Depressive Disorder With Music and Low-frequency Rhythmic Sensory Stimulation
Major depressive disorder (MDD) is a highly prevalent and disabling disorder associated with persistent low mood, loss of the capacity to experience pleasure (i.e.
- Trial name
- NCT02685982
- Testing
- Rhythmic Sensory Stimulation
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Ultrasound Airway Imaging in Determining the Oral Cavity and Tongue Size
A Comparative Study of Ultrasound Versus CT Measurement of Tongue and Oral Cavity Size
Difficulty in managing the airway is the single most important cause of major anesthesia-related morbidity and mortality. The currently used clinical method of predicting airway difficulty used by anesthetists is limited and not…
- Trial name
- NCT02952560
- Testing
- Ultrasound scan
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Post Operative Analgesia, Regional Anesthesia
Does Interneural Local Anesthetic Spread at the Site of Sciatic Nerve Bifurcation Shorten Block Onset Time?
Following foot and ankle surgery, ultrasound-guided sciatic nerve block (SNB) at the popliteal fossa decreases post-operative pain and opioid consumption.
- Conditions
- Post Operative Analgesia, Regional Anesthesia, Sciatic Nerve Block
- Trial name
- NCT01568476
- Testing
- Distal, Interneural
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- University Health Network, Toronto
Spinal Anesthesia
Ultrasound-assisted Spinal Anaesthesia in Patients With Difficult Anatomical Landmarks
Spinal anesthesia is the technique of choice in patients undergoing total joint arthroplasty at Toronto Western Hospital (UHN). The most significant predictor of the ease of performance of spinal anesthesia is the quality of…
- Trial name
- NCT00956137
- Testing
- Ultrasound guidance, Manual palpation
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Hand or Arm Surgery
Medial Versus Lateral Approach in Ultrasound (US)-Guided Supraclavicular Block
The ultrasound guided supraclavicular block is a peripheral nerve block which is considered safe, has a fast onset, is dense and provides complete block of the nerves supplying the hand, forearm and arm.
- Trial name
- NCT00992810
- Testing
- Lateral-to-Medial Approach, Media-to-Lateral Approach
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
Papillary Thyroid Cancer
CT Detection of Metastatic Lymphadenopathy in Papillary Thyroid Cancer
Localized thyroid cancer is potentially curable. Before thyroid surgery, an ultrasound test is done to see if cancer has spread to the lymph nodes in the neck.
- Trial name
- NCT03359668
- Testing
- Use of IV contrast during head and neck CT
- Volunteers
- 47 people
- Sponsor
- University Health Network, Toronto
Recurrent Prostate Cancer
MRI-Guided Biopsy of Recurrent Prostate Cancer After Radiotherapy
In this study we will test a new procedure to guide needle biopsies into the prostate gland based on MRI. This study will be conducted in patients who may have recurrence of their cancer in the prostate gland after radiation…
- Trial name
- NCT00775866
- Testing
- MRI-Guided Biopsy
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University Health Network, Toronto
Ankle/Foot Surgery
Ultrasound Guided Popliteal Fossa Block. Does Blockade Distal to Sciatic Nerve Bifurcation Speed Onset Time? A Prospective, Randomized Trial
Sciatic nerve block is used routinely in ankle and foot surgery. It is applied often by a posterior approach at the popliteal fossa, near where the nerve divides into the common peroneal and tibial nerves.
- Trial name
- NCT00803426
- Testing
- Sciatic nerve blockade for ankle/foot surgery
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University Health Network, Toronto
Nausea
Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery
The study aims to compare the incidence of side effects caused by Oxycodone and Hydromorphone.
- Trial name
- NCT02295124
- Testing
- Oxycodone, Hydromorphone
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Diabetic Neuropathy
Can Ultrasound Predict Nerve Injury Following Posterior Tibial Nerve Block in Patients With Peripheral Neuropathy?
The use of regional anesthesia for nerve block in diabetic patients with peripheral neuropathy is currently made on a case-by-case basis, also remains underlying uncertainty regarding the preferred technique and the likelihood of…
- Trial name
- NCT01002053
- Testing
- Nerve conduction study and Ultrasound of the PTN
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Total Knee Arthroplasty
Adductor Canal Block and Recovery After Total Knee Replacement Surgery
This study aims to compare the functional recovery of patients undergoing Total Knee Arthroplasty based on the administration of an adductor canal block during their anesthesia treatment
- Trial name
- ACB in TKA (NCT02411149)
- Testing
- Adductor Canal Block, Adductor Canal Block with Morphine, Local Infiltration
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Aspiration
Accuracy of Gastric Ultrasound to Diagnose a "Full Stomach". A Bayesian Framework
During surgery, there is a risk that food or liquid in the stomach might be forced back up the throat where it could enter the lungs (aspirate) and result in serious complications or even death.
- Trial name
- NCT02588495
- Testing
- Food intake
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Total Knee Arthroplasty, Total Hip Arthroplasty
Dexamethasone in Total Knee and Total Hip Arthroplasty
This study will evaluate if the addition of dexamethasone to a local infiltration analgesia mixture will improve functional outcomes following total hip and knee arthroplasty.
- Conditions
- Total Knee Arthroplasty, Total Hip Arthroplasty, Osteoarthritis
- Trial name
- NCT02760043
- Testing
- Dexamethasone, LIA Combination Mixture
- Where
- Canada
- Volunteers
- 314 people
- Sponsor
- University Health Network, Toronto
Systemic Lupus Erythematosus
Scrutinizing the Heterogeneity of SLE: Defining Phenotypes
SLE disease course is characterized by unpredictable relapses and remissions in the majority of patients. However, in a small proportion (approximately 5%), SLE presents with a monophasic pattern, meaning that these patients have…
- Trial name
- NCT03348774
- Where
- Canada
- Volunteers
- 950 people
- Sponsor
- University Health Network, Toronto
Renal Insufficiency, Chronic, Hypertension
Mobile Health Technology for Chronic Kidney Disease Patients: Medication Management
Patients with complex, long-lasting conditions such as chronic kidney disease (CKD) often take multiple medications and frequently have serious medication problems, arising from poor communication between doctors and patients.
- Conditions
- Renal Insufficiency, Chronic, Hypertension, Medication Reconciliation, Mobile Applications
- Trial name
- NCT02905474
- Testing
- Usual Care, Integrated mobile medication app, Commercially available mobile medication app
- Where
- Canada
- Volunteers
- 182 people
- Sponsor
- University Health Network, Toronto
Liver Cancer
Oblimersen and Doxorubicin in Treating Patients With Advanced Hepatocellular Carcinoma (Liver Cancer)
RATIONALE: Drugs used in chemotherapy such as doxorubicin use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00047229
- Testing
- oblimersen sodium, doxorubicin hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 27 people
- Sponsor
- University Health Network, Toronto
Stroke
MyndMove Therapy for Severe Hemiparesis of the Upper Limb Following Stroke
The purpose of this study is to examine the efficacy of MyndMove therapy in the early sub-acute, late sub-acute and chronic post-stroke patients.
- Trial name
- NCT03323632
- Testing
- MyndMove
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University Health Network, Toronto