Clinical trials: sponsored by University Hospital, Angers
Screening, Advanced Liver Fibrosis
SCREaning of Advanced Liver Fibrosis Using Non-Invasive Tests in General Population
The main objective of the study is to evaluate the pertinence of initiating screening for advanced hepatic fibrosis after a FIB4 result > 2.67 automatically calculated in the local laboratory and followed by a specialized hepatic…
- Trial name
- SCREANIT (NCT05880173)
- Testing
- FIB4
- Where
- 6 sites in France
- Volunteers
- 391 people
- Sponsor
- University Hospital, Angers
Acute Hypoxemic Respiratory Failure
IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure requires endotracheal intubation and invasive mechanical ventilation in approximately 30-40% of cases, due to severe hypoxemia and/or clinical signs of acute respiratory distress.
- Trial name
- IntHyx (NCT07189078)
- Testing
- Restrictive intubation strategy, Liberal intubation strategy
- Where
- 9 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Quality of Life, Non Invasive Ventilation
Quality of Life and Quality of Sleep Studies in Children With Home Care Ventilation in the West of France
Home ventilation in children, invasive or non invasiv,e is an interesting treatment for different disease which cause chronic respiratory impairement. The aim of this treatment is to support alveolar hypoventilation.
- Trial name
- EQuaViSE (NCT05368662)
- Testing
- Quality of life and sleep questionnaire
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Angers
Aging, Fall
Changes in Spatiotemporal Gait Parameters During a Digitally Assisted Self-rehabilitation Program for Elderly Fallers ( DigiWalk )
Falls are a health issue that is both common among older adults (affecting 1 in 2 people each year after age 80) and serious due to their traumatic, psychological, and functionally disabling complications.
- Conditions
- Aging, Fall, Fall Accident
- Trial name
- DigiWalk (NCT07741994)
- Testing
- PFPP Group, Control Group
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Acute Respiratory Distress Syndrome (ARDS), s100b
A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), s100b, Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NEURDS (NCT07629973)
- Testing
- Blood test scores calculations
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Human Health in Extreme Conditions
CHOICE KERGUELEN 1: Consequences of Longterm Confinement on Immunity in the Sub-Antarctic Islands: Inclusion of Volunteers Before Departure to the Kerguelen Islands
Living for long periods in extreme environments-like Antarctic research stations or space missions-can have a significant impact on human health, especially on the immune system.
- Trial name
- NCT07065253
- Testing
- blood ponction, urines collection, hair collection
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Autosomal Dominant Spinocerebellar Ataxia (SCA1, 2,3,6,7,27B)
Autosomal Dominant Spinocerebellar Ataxias and Social Cognition
Spinocerebellar ataxias are a group of rare neurodegenerative diseases, clinically and genetically highly heterogeneous, with an estimated mean prevalence of 2.7 per 100,000 population.
- Trial name
- SoCoSca (NCT07099651)
- Testing
- tests
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Postoperative Ileus
Study of the Efficience of Chewing-gum to Reduce the Duration of Postoperative Ileus
Postoperative ileus (POI) is a serious complication after surgery. While it complicates all type of surgery, it is more frequent after abdominal surgery (especially bowel or colorectal surgery).
- Trial name
- CHEWIP (NCT05296967)
- Testing
- chewing
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Angers
Long COVID
Characterization of the Immunometabolic Signature in Long COVID-19.
The primary objective of this study is to identify immunometabolic signatures associated with Long COVID in plasma and peripheral blood mononuclear cells (PBMC).
- Trial name
- LoCo-ImMet (NCT05758480)
- Testing
- Blood sample (at inclusion and 6 months later), Patient questionnaires (at inclusion and 6 months later)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis)
Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study)
This study focuses on two serious and common medical conditions: heart failure and pulmonary embolism (a blood clot in the lungs).
- Conditions
- Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis), Venous Thromboembolism
- Trial name
- PEHF (NCT07499661)
- Testing
- Systematic screening for pulmonary embolism in all patients using a guideline-recommended diagnostic algorithm
- Where
- 10 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Angers
Acute Myeloid Leukemia (AML)
Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR
This open label, multicenter phase II/III study with multiple randomization phases at differents stages of AML treatment (induction, consolidation and HSCT where applicable) is designed to improve OS in younger (18 to 60…
- Trial name
- BIG-1 (NCT02416388)
- Testing
- Idarubicin, Daunorubicin, HD Cytarabine
- Where
- 56 sites in France
- Volunteers
- 3,100 people
- Sponsor
- University Hospital, Angers
Hepato Cellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma
Outpatient Versus Inpatient Care Pathway for Intra-arterial Treatment of Primary Liver Cancer (CHOC)
Randomized multicentre trial comparing two care organisations (ambulatory vs conventional inpatient) for patients undergoing transarterial chemoembolization (TACE) or radioembolization (TARE) for primary liver cancer (Hepato…
- Trial name
- CHOC (NCT06990659)
- Testing
- Ambulatory care, Conventional inpatient care
- Where
- 19 sites in France
- Volunteers
- 206 people
- Sponsor
- University Hospital, Angers
Pulmonary Embolism
Diagnostic Strategy for Suspected Pulmonary Embolism Based on 4PEPS
The increased use of diagnostic imaging and especially computed tomography pulmonary angiography in patients suspected of pulmonary embolism (PE) is an important point of concerns.
- Trial name
- SPEED&PEPS (NCT06015529)
- Testing
- 4PEPS strategy
- Where
- 23 sites in Belgium, France
- Volunteers
- 3,084 people
- Sponsor
- University Hospital, Angers
Low Back Pain
Effectiveness of Coordinated Care to Reduce the Prolonged Disability Risk Among Patients Suffering From Low Back Pain in Primary Care
Common low back pain affects about 23% of general population and can be associated with psychosocial difficulties and prolonged inability to work.
- Trial name
- COLOMB (NCT04826757)
- Testing
- Coordinated care
- Where
- 20 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Angers
Cushing Syndrome, Fatty Liver Disease
NAC- NAFLD And Cushing
Cushing's Syndrome is a rare disease resulting from prolonged exposure to high levels of circulating cortisol. Clinical manifestations are variable but many patients present a metabolic syndrome (abdominal obesity, insulin…
- Trial name
- NAC (NCT05881005)
- Testing
- hepatic MRI
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Barrett Esophagus, Dysplasia
A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus
Barrett Esophagus is a common pathology, with an estimated prevalence of 1.6% at risk of progression to precancerous mucosa (low to high grade dysplasia). The incidence of adenocarcinoma on BE is 0.5% per year.
- Trial name
- ENDOBARRETT (NCT04867590)
- Testing
- Endorotor, Radiofrequency
- Where
- 17 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Angers
Non-alcoholic Fatty Liver Disease (NAFLD), Alcoholic Liver Disease (ALD)
Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic Patients
The primary objective of the SOPRANO study is to compare two blood fibrosis tests, the eLIFT and the FibroMeter, for the screening of advanced liver fibrosis in patients with NAFLD and/or ALD from primary care centers.
- Conditions
- Non-alcoholic Fatty Liver Disease (NAFLD), Alcoholic Liver Disease (ALD), Liver Fibrosis
- Trial name
- SOPRANO (NCT05699018)
- Testing
- eLIFT
- Where
- 13 sites in France
- Volunteers
- 1,788 people
- Sponsor
- University Hospital, Angers
Rare Diseases, Genetic Disease
Functional Study to Indentify Genetic Etiology of Rare Diseases - ORIGIN
Next generation sequencing (NGS) allows some better diagnostic results, particularly, in the rare diseases field. At a twenty five percent rate, those exams highlight some variants which are not yet described in human pathology.
- Trial name
- ORIGIN (NCT05499091)
- Testing
- Skin biopsy, blood sample, urine sample
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Angers
Neurodevelopmental Disorders and Developmental Abnormalities
Transcriptomic Approach for the Identification and Prioritization of Genome Variants in Neurodevelopmental Disorders With Malformation
Three million persons in France are impacted by rare diseases. Amid the 7000 different diseases which are identified today, neurodevelopmental disorders are the main symptoms found interesting 35 000 birth every years, according…
- Trial name
- ATOMICS (NCT06762678)
- Testing
- RNA sequencing and whole genome sequencing in a trio way
- Where
- 7 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Angers
Acute Renal Failure
Measurement of Iohexol Plasma Clearance in Patients Leaving ICU After Acute Renal Failure
IOXSOR study's purpose to determine the frequency of non resolutive renal failure (estimated by the clearance of iohexol) at end of stay in ICU patients who have had acute renal failure episode.
- Trial name
- IOXSOR (NCT02961478)
- Testing
- IOHEXOL
- Where
- 11 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers