Clinical trials: sponsored by University Hospital, Angers
Acute Pulmonary Embolism
HOME-PE2 : Home Treatment Versus Hospitalization in Patients With Acute Pulmonary Embolism, no Clinical Severity Criteria, and Either Right Ventricular Dysfunction or Elevated Troponin: a Randomized Controlled Trial
This study (HOME-PE2) is a multicenter, randomized controlled trial comparing home treatment versus hospitalization in patients with acute pulmonary embolism (PE) who have no clinical severity criteria according to the Hestia…
- Trial name
- HOME-PE2 (NCT07506291)
- Testing
- Home treatment, Hospitalization
- Where
- 18 sites in France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Angers
Acute Appendicitis
TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods
Acute appendicitis is the most common abdominal surgical emergency in children and a frequent cause of pediatric emergency department visits.
- Trial name
- TACTILE (NCT07479849)
- Testing
- Score-based appendicitis risk classification in teleconsultation
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Angers
Huntington's Disease (HD), Exergame
Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
Huntington's disease (HD) is a rare, hereditary neurodegenerative disorder. It generally manifests itself between the ages of 40 and 50, and results in motor impairment (choreic movements, balance disorders, gait disorders…
- Trial name
- CARE-MH (NCT06807892)
- Testing
- Synergistic management, Sequential management
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Cystitis Acute
Evaluation of the Effectiveness of a Protocol for the Management of Female Functional Urinary Signs
Every year, between 4 and 6 million French people are affected by a urinary infection; the vast majority of these are women. Although the diagnosis of an uncomplicated urinary tract infection is simple to make, it requires prompt…
- Trial name
- PharmaCyst' (NCT05510128)
- Testing
- Pharmacist management
- Where
- 14 sites in France
- Volunteers
- 145 people
- Sponsor
- University Hospital, Angers
Sacrococcygeal Pilonidal Sinus
Effectiveness of Different Surgical Techniques for Curative Treatment of Pilonidal Sinus Disease in the Pediatric Population
Pilonidal sinus disease (PSD) in children is associated with significant morbidity and recurrence risk. Multiple surgical techniques are used, including excision with open healing, primary midline closure, off-midline closure…
- Trial name
- PiloPedia (NCT07470294)
- Testing
- Surgical treatment for pilonidal sinus disease, including various techniques including excision with or without primary closure, or endoscopic techniques.
- Volunteers
- 90 people
- Sponsor
- University Hospital, Angers
Hirschsprung Disease
Surgical Approach for the Treatment of Hirschsprung Disease Using the Swenson Technique (SMILES)
Hirschsprung disease (HD) is a rare congenital disorder of the enteric nervous system, affecting approximately 1 in 5,000 live births.
- Trial name
- SMILES (NCT07468565)
- Testing
- transanal or laparoscopy assisted Swenson coloanal pullthrough
- Volunteers
- 70 people
- Sponsor
- University Hospital, Angers
Category 3 Study (Non-interventional Research)
Evaluation of an Environmental Counsellor's Home Stay in Children Treated for Asthma or Allergic Rhinitis Via a Standardized Medical Questionnaire Randomized Controlled Superiority Trial in Parallel Arms, Multicentric (EvalPCE)
Assessment of asthmatic children and children with allergic rhinitis at day 0 and 6 months after a home visit by an environmental consultant via standardized medical questionnaires.
- Trial name
- EvalPCE (NCT04927689)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Myelofibrosis
Clonal Architecture of ASXL1-mutated Myelofibrosis
Prospective study to decipher the clonal architecture of ASXL1-mutated primary and secondary myelofibrosis and its impact on prognosis
- Trial name
- CLONEMF (NCT05710211)
- Testing
- Clonal architecture determination
- Where
- 13 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Vasospasm
Milrinone Infusion for VAsospam Treatment in Subarachnoid hemoRrhage
Subarachnoid hemorrhage (SAH) is a frequent and severe disease. Mortality can reach 40%. The most frequent complication of SAH is arterial vasospasm, with estimated incidence as high as 70%.
- Trial name
- MIVAR (NCT04362527)
- Testing
- Milrinone 1 Mg/mL Solution for Injection, Saline solution for injection
- Where
- 16 sites in France
- Volunteers
- 370 people
- Sponsor
- University Hospital, Angers
Healthy Volunteers
Intraosseous Doppler Ultrasonography to Study Skeletal Physiology: Exploratory Study Before Use in Space Physiology
Use of intraosseous Doppler ultrasonography to study skeletal physiology ("Echo-Os Study"). Exploratory study before its use in space physiology. Bones have a complex vascular network providing nutrients and oxygen to bone cells.
- Trial name
- Echo-Os (NCT06206031)
- Testing
- Intraosseous ultrasonography at tibia before, during, and after a physiological vascular stimulation (venous occlusions, arterial occlusion, handgrip)
- Where
- 2 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Myeloproliferative Neoplasm, Essential Thrombocythemia
Interest of CALR Allele Burden in Diagnosis and Follow-up of Patients With CALR Mutated Myeloproliferative Syndromes (CALRSUIVI)
Prospective study to evaluate the relevance of CALR allele burden monitoring as a molecular marker of disease progression.
- Conditions
- Myeloproliferative Neoplasm, Essential Thrombocythemia, Primary Myelofibrosis, Prefibrotic Stage, Primary Myelofibrosis, Fibrotic Stage
- Trial name
- CALRSUIVI (NCT04942080)
- Testing
- CALR allele burden quantification
- Where
- 10 sites in France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Angers
Kidney Transplantation
Impact of ExtraCorporeal Phototherapy (ECP) on Auxiliary Follicular T-lymphocytes and Circulating B-lymphocytes During Chronic AntiBody-Mediated Rejection in Kidney Transplantation.
Chronic AntiBody-Mediated Rejection (cABMR) is the leading cause of late kidney transplant loss (after 1 year of kidney transplantation).
- Trial name
- IPECAM (NCT04870437)
- Testing
- Extracorporeal phototherapy
- Where
- 4 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Myeloproliferative Neoplasm
Identification of Factors Associated With Treatment Response in Patients With Polycythemia Vera, Essential Thrombocythemia, and Pre-myelofibrosis.
First-line treatment for patients with polycythemia vera, essential thrombocythemia, and pre-myelofibrosis is based on hydroxyurea or pegylated interferon.
- Trial name
- BioPredictor (NCT05440838)
- Testing
- Next-generation sequencing
- Where
- 6 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Angers
Septic Shock
Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock
This study evaluates if improvement of renal resistive index when mean arterial pressure increase (at 65 mmHg to 85 mmHg) in early phase of septic shock is predictive of better renal survival.
- Trial name
- SEPSIR (NCT04281277)
- Testing
- increase of mean arterial pressure at 80-85 mmHg., increase of mean arterial pressure at 65-70 mmHg.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Acute Myeloid Leukemia, Hodgkin's Lymphoma
Evaluation of Chemotherapy-induced Cognitive Disorders During the Treatment of Hematological Malignancies
Chemotherapy-induced cognitive disorders, such as memory problems, slowness of execution, inability to concentrate, and language difficulties, are sequelae that occur in patients undergoing chemotherapy or who have received…
- Conditions
- Acute Myeloid Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma
- Trial name
- HematoBrain (NCT07147621)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.
The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as "absent," "moderate,"…
- Trial name
- SURVEX (NCT07452952)
- Testing
- Non-interventionnal study
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Parent-Child Relations
Assessment of the Mental State of Parents of Premature Children and Impact on Neurodevelopment of the Child
The objective of the study is to assess the psychic profile of parents of children born prematurely
- Trial name
- PoPPY (NCT04827225)
- Testing
- questionnaires
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Allergic Reaction
Human Seminal Plasma Allergy: Quality of Life
Human Seminal Plasma Allergy (HSPA) is a rare allergy with localized and/or generalized manifestations following exposure during unprotected sex. Its cause remains undetermined and is certainly underdiagnosed.
- Trial name
- ALExSEM (NCT07391917)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Duodenal Obstruction
Bilio-pancreatic Complications of Congenital Duodenal Obstructions
Congenital duodenal obstructions, often grouped under the term duodenal atresias, encompass a range of malformations of the duodenum that cause partial or complete obstruction.
- Trial name
- Bilious (NCT06642805)
- Testing
- duodenal atresia
- Volunteers
- 450 people
- Sponsor
- University Hospital, Angers
Myocardial Infarction, Ventricular Remodeling
Disparities in Myocardial Infarction Remodeling According to Gender
Following myocardial infarction, female individuals demonstrate a poorer prognosis, characterized by elevated rates of mortality and heart failure. A primary hypothesis suggests unfavorable cardiac remodeling in women.
- Trial name
- REMOVE 2 (NCT06343844)
- Testing
- cardiac imaging to assess left ventricular volumes and function
- Where
- France
- Volunteers
- 1,650 people
- Sponsor
- University Hospital, Angers