Clinical trials: sponsored by University Hospital, Antwerp
Obstructive Sleep Apnea
Optimal Dosage of Acetazolamide for OSA Treatment
Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA).
- Trial name
- NCT04726982
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 91 people
- Sponsor
- University Hospital, Antwerp
Mastectomy, Breast Reconstruction
Near-infrared Spectroscopy for Monitoring Tissue Oxygenation in Breast Reconstruction
The study will evaluate the use of near infrared spectrometry (NIRS)in detecting early microvascular complications in deep inferior epigastric artery perforator (DIEP)-flap(s).
- Conditions
- Mastectomy, Breast Reconstruction, Flap Ischemia
- Trial name
- NCT03757793
- Testing
- FORE-SIGHT ELITE monitor
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea, Sleep Apnea
Hypoglossal Nerve Stimulation Therapy in Patients With Obstructive Sleep Apnea: Belgian Registry
Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea
- Trial name
- B-HNS (NCT06332404)
- Testing
- Hypoglossal nerve stimulation Inspire system (Inspire Medical Systems Inc., USA)
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- University Hospital, Antwerp
Cesarean Section Complications, Hemodynamic Instability
Norepinephrine in Caesarian Section
Postspinal hypotension is a frequent maternal complication in caesarian delivery under neuraxial anesthesia which is most commonly treated with the administration of phenylephrine infusion.
- Conditions
- Cesarean Section Complications, Hemodynamic Instability, Foetal Stress
- Trial name
- NCT05264870
- Testing
- Norepinephrine
- Where
- Belgium
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea, Sleep Apnea
Non-inferiority Analysis of Two Titration Methods for Hypoglossal Nerve Stimulation Therapy
Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea
- Trial name
- DOT-PSG (NCT06559956)
- Testing
- Daytime titration polysomnography
- Where
- Belgium
- Volunteers
- 110 people
- Sponsor
- University Hospital, Antwerp
Vaginal Microbiome
The Maggie Project: Exploring the Origin and Heredity of the Vaginal Microbiome
The vaginal microbiome plays a crucial role in women's health and reproduction, impacting not only women but also their partners and children. However, its ecology and primary colonizers are not well understood.
- Trial name
- Maggie (NCT06912126)
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Allergic Reaction, Hypersensitivity
Standardised Drug Provocation Testing in Perioperative Hypersensitivity
The goal of this clinical trial is to evaluate the safety and outcome of systematic drug provocation testing with anaesthetics at therapeutic doses in adult patients undergoing diagnostic work-up for perioperative…
- Conditions
- Allergic Reaction, Hypersensitivity, Perioperative Complication, Anaphylaxis
- Trial name
- NCT06065137
- Testing
- Full dose DPT with propofol, Full dose DPT with ketamine, Full dose DPT with etomidate
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Multiple Sclerosis
A Clinical Trial Evaluating the Safety and Efficacy of Myelin-peptide Loaded tolDC as Treatment for MS
The investigators propose to design and conduct a phase II clinical trial to treat patients with multiple sclerosis (MS) by vaccination with tolerogenic dendtritic cells (tolDC), generated using Good Manufacturing Practices…
- Trial name
- MS-tolDC_2 (NCT06715605)
- Testing
- tolerogenic dendritic cells (tolDC), Standard-of-care
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Pleural Epithelioid Mesothelioma, Mesothelioma; Pleura
NEoadjuvant Chemotherapy and Immunotherapy for a Selected Group of Inoperable Pleural Mesothelioma Patients (NECIM): a Feasibility Study
The goal of this clinical trial is to evaluate whether a combination of chemotherapy and immunotherapy can make surgery possible in adults with inoperable pleural mesothelioma (a type of cancer affecting the lung lining).
- Conditions
- Pleural Epithelioid Mesothelioma, Mesothelioma; Pleura, Neoadjuvant Chemoimmunotherapy
- Trial name
- NECIM (NCT07121374)
- Testing
- Neoadjuvant chemo-immunotherapy, Extended pleurectomy/decortication in case of reaching operability
- Where
- Belgium
- Volunteers
- 37 people
- Sponsor
- University Hospital, Antwerp
Endothelial Function (FMD), Preeclampsia
Identifying Biomarkers for Endothelial Dysfunction in Women With Preeclampsia
Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus.
- Conditions
- Endothelial Function (FMD), Preeclampsia, Retinal Vessels
- Trial name
- DAISY (NCT07084727)
- Testing
- Arterial stiffness, Flow-meditad dilatation, Dynamic retinal vessel analyzer
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Laryngoscopy, Child
Airway Interventions During Intravenous Anesthesia in Children Undergoing Direct Laryngoscopy for Surgical Procedures Using High Flow Nasal Versus Low Flow Oxygen. A Pilot Study.(Flowkid)
The goal of this clinical trial is to evaluate possible differences in airway responses and interventions during intravenous anesthesia for direct laryngoscopy in children when comparing two oxygenation methods (conventional low…
- Conditions
- Laryngoscopy, Child, Oxygen Therapy
- Trial name
- NCT06037915
- Testing
- low flow oxygen with nasopharyngeal tube, high flow oxygen with OptiflowTM Nasal High Flow
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Sleep Apnea Syndrome (OSAS), Sleep Apnea Syndrome
Personalised Treatment for OSA
Obstructive sleep apnea (OSA) is a sleep disorder characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep.
- Conditions
- Sleep Apnea Syndrome (OSAS), Sleep Apnea Syndrome, Sleep Apnea Syndrome, Obstructive, Sleep Apnea/Hypopnea Syndrome
- Trial name
- NCT06915077
- Where
- Belgium
- Volunteers
- 850 people
- Sponsor
- University Hospital, Antwerp
Perineal Descent, Obstructed Defecation Syndrome (ODS)
Clinical Evaluation of the Femiset Device for Perineal Descent in Women
The University of Antwerp developed a device (Femiset) to alleviate defecation difficulties in women suffering from Descending Perineum Syndrome (DPS).
- Trial name
- FEMISET (NCT07039188)
- Testing
- Use device in home environment
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration
This clinical trial aims to demonstrate that metformin can prevent clinical disability in patients with progressive MS by stopping or slowing down neurodegeneration by enhancing endogenous remyelination.
- Conditions
- Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary-progressive Multiple Sclerosis
- Trial name
- NCT05893225
- Testing
- Metformin Hydrochloride 850 mg Oral Tablet
- Where
- 5 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Antwerp
Multiple Sclerosis
Remote MS Care in Antwerp
Current clinical follow-up of multiple sclerosis (MS) patients suffers from some challenges, as many patients indicate they want to take up a more active role in the decision-making process.
- Trial name
- ReMSCA (NCT06179758)
- Testing
- icompanion app
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Intermittent Fasting, Gut Microbiome
The Rufaida Project: Researching the Impact of Ramadan Fasting on the Gut and Vaginal Microbiome
The body's systems are deeply connected, but they are often studied separately. A recent large-scale citizen-science project on women's health, called Isala, discovered a group of gut-related bacteria present in the vaginal…
- Conditions
- Intermittent Fasting, Gut Microbiome, Vaginal Microbiome
- Trial name
- Rufaida (NCT07001358)
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Malignant Pleural Mesothelioma
Autologous Dendritic Cell Vaccination in Mesothelioma
In this multicenter phase I/II trial, dendritic cells (DCs) loaded with the mesothelioma-associated tumor antigen WT1 will be used in conjunction with conventional chemotherapy for the frontline treatment of malignant pleural…
- Trial name
- MESODEC (NCT02649829)
- Testing
- dendritic cell vaccination plus chemotherapy
- Where
- 3 sites in Belgium
- Volunteers
- 28 people
- Sponsor
- University Hospital, Antwerp
Acute Myocarditis
MYTHS-MR Trial (MYocarditis THerapy With Steroids in Patients With Mildly Reduced Ejection Fraction)
The goal of this clinical trial is to demonstrate the efficacy of pulsed intravenous methylprednisolone in a single-blind randomized controlled trial versus standard therapy in patients with acute myocarditis and a mildly reduced…
- Trial name
- MYTHS-MR (NCT05974462)
- Testing
- Methylprednisolone 125 MG, IV saline solution 0.9%
- Where
- 19 sites in Belgium, Italy and 2 more
- Volunteers
- 174 people
- Sponsor
- University Hospital, Antwerp
Sepsis, Trauma Related Injuries
Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies
In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this…
- Conditions
- Sepsis, Trauma Related Injuries, Subarachnoid Haemorrhage (SAH)
- Trial name
- ICU-FERRO (NCT06928649)
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Antwerp