Clinical trials: sponsored by University Hospital, Antwerp
Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
Treatment With ABT-199 (Venetoclax) and Purine Analogues in Relapsed/Refractory Acute Myeloid Leukemia
Non-commercial, open-label interventional phase Ib study to assess the effectivity of the combination of venetoclax and 6-mercaptopurine in patients with relapsed or refractory AML.
- Trial name
- NCT05506332
- Testing
- Venetoclax, 6-mercaptopurine
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Surgery Ambulatory
Spinal or Intravenous Dexmedetomidine in Ambulatory Surgery
The primary objective of this double blind randomized study is to determine the effect of dexmedetomidine on onset and duration of the sensory and motor block and on the influence on bladder function after spinal anesthesia with…
- Trial name
- NCT02282319
- Testing
- spinal dexmedetomidine 0.5 mcg, spinal chloroprocaine 40 mg, IV dexmedetomidine 0.5 mcg/kg
- Where
- 2 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Combined Spinal Epidural Anesthesia, Prilocaine
Spinal Prilocaine for Caesarian Sections
Prilocaine theoretically could provide faster onset because of its lower pKa (7,7) compared to bupivacaine (8,1). The primary objective of this prospective double blind randomized trial is to determine block onset of spinal…
- Conditions
- Combined Spinal Epidural Anesthesia, Prilocaine, Bupivacaine, Pain
- Trial name
- NCT03219086
- Testing
- combined spinal epidural anaesthesia, Prilocaine, Bupivacaine
- Where
- 3 sites in Belgium
- Volunteers
- 182 people
- Sponsor
- University Hospital, Antwerp
Nerve Block, Surgery
Ultrasound Guided Topographic Mapping of Medial Antebrachial Cutaneous Nerve
Blocking the medial antebrachial cutaneous nerve (MACN) during an axillary block often a subcutaneous wheal of local anesthetics is made what is described as painful.
- Conditions
- Nerve Block, Surgery, Anesthesia, Brachial Plexus Block
- Trial name
- NCT03211949
- Testing
- axillary block, Scandicaine
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Shift-work Disorder, Insomnia
SHIFTPLAN: an RCT Investigating the Effect of a Shift Work Intervention on Fatigue, Sleep and Health.
Shift work is associated with disturbed life rhythms resulting from chronic exposure to circadian misalignment and sleep restriction, with long-term participation in most shift schedules causing serious health problems.
- Conditions
- Shift-work Disorder, Insomnia, Fatigue, Mental Health Issue
- Trial name
- SHIFTPLAN (NCT05452096)
- Testing
- Education program and ergonomic schedulling
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp
Tinnitus
A Randomized Controlled HD-tDCS Trial: Effects on Tinnitus Severity and Cognition
This randomized, placebo-controlled study will compare the effects of HD-tDCS (a non-invasive neuromodulation technique) with a sham stimulation.
- Trial name
- NCT03754127
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 81 people
- Sponsor
- University Hospital, Antwerp
Fistula in Ano, Rectal Fistula
Laser Assisted Treatment of Fistula In Ano
Randomised Controlled Trial comparing Laser assisted closure of transsphincteric fistula to the rectal advancement flap.
- Trial name
- LATFIA (NCT05390151)
- Testing
- Laser treatment of anal fistula, RAF
- Where
- 5 sites in Belgium
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Pain, Monitoring, Intraoperative
Evaluation of the Pupil Dilation Reflex in Response to Noxious Stimulation in Anaesthetized Children. A Proof of Concept Trial
After conduction a pilot study, pupillary dilation reflex (PDR) is measured in response to nociceptive stimulation perioperatively in infants, children and adolescents.
- Trial name
- Pain@OR-kids (NCT03449732)
- Testing
- PDR measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Ischemic Stroke, Intracranial Aneurysm
Analysis of Selective Cerebrovascular Distribution With FDCT in the Angiosuite
The aim of this study is to evaluate the clinical feasibility of the angiographic Flat Detector CT perfusion imaging (6s PBV) technique.
- Conditions
- Ischemic Stroke, Intracranial Aneurysm, Intracranial Arterial Diseases, Cerebral Hypoxia
- Trial name
- NCT03916133
- Testing
- Intervention group
- Where
- Belgium
- Volunteers
- 127 people
- Sponsor
- University Hospital, Antwerp
Allergic Rhinoconjunctivitis
Probiotic Chewables in Allergic Rhinoconjunctivitis Patients
With this double- blind, randomised, placebo-controlled study, the investigators want to investigate the influence of a chewable with the probiotic strain Lacticaseibacillus rhamnosus GG on the symptoms and immunological markers…
- Trial name
- NCT04898686
- Testing
- Probiotic chewables
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- University Hospital, Antwerp
Hyperacusis
Exploratory Study on the Role of Somatic Modulation in Hyperacusis
This study focuses on patients with a primary complaint of hyperacusis. Hyperacusis has been defined as 'abnormally reduced tolerance to sound' and is commonly associated with tinnitus.
- Trial name
- NCT04693819
- Testing
- Somatic modulation
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- University Hospital, Antwerp
Quality of Life
Patient-reported Outcomes in Neuroendocrine Neoplasms: a Prospective Quality of Life and Quality of Care Study Within NETwerk
Neuroendocrine tumors (NET) are rare tumors that require specific diagnosis and treatment. Therefore, this poses a challenge for clinical practice.
- Trial name
- Quali-NET (NCT05268783)
- Testing
- EORTC QLQ-C30, EORTC QLQ-GI.NET21, Satisfaction survey
- Where
- 7 sites in Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Antwerp
Insulin Resistance, Type 1 Diabetes
Validation of a 13C Glucose Breath Test Compared With the Euglycaemic Clamp Test
Insulin resistance can be assessed by the euglycaemic clamp technique. To date, this is the golden standard, but it is not suited for clinical practice. A 13C glucose breath test will be tested as a valid alternative.
- Trial name
- BRECLAIR (NCT04623320)
- Testing
- euglycaemic clamp test, 13C glucose breath test
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Neuroendocrine Tumors
A Study to Evaluate the Value of Circulating Tumour DNA in Follow-up of Patients With an Advanced Gastroenteropancreatic or Lung Neuroendocrine Tumour Under Everolimus +- SSA Treatment (Liquid-NET 2.0)
Prospective, multicentric, single arm, POC study to evaluate the value of CtDNA in follow-up of patients treated with everolimus, with or without somatostatin analogues for advanced gastroenteropancreatic or lung neuroendocrine…
- Trial name
- NCT05268952
- Testing
- Liquid biopsies, Scans (CT, gallium-68 DOTATE/TOC/NOC PET-CT)
- Where
- 3 sites in Belgium, Cyprus
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
NAFLD, Type 1 Diabetes
Prevalence, Incidence and Characteristics of NAFLD/NASH in Type 1 Diabetes Mellitus
Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by intrahepatic fat accumulation. It is closely related to insulin resistance.
- Conditions
- NAFLD, Type 1 Diabetes, Cardiovascular Diseases
- Trial name
- NAFLDIA1 (NCT04664036)
- Testing
- ultrasound, elastography, controlled attenuation parameter (CAP)
- Where
- Belgium
- Volunteers
- 700 people
- Sponsor
- University Hospital, Antwerp
Metastatic Pancreatic Ductal Adenocarcinoma
Retrospective Study on the Efficacy and Tolerability of Liposomal Irinotecan
The aim of this retrospective study is to confirm the efficacy and safety results obtained in the NAPOLI-1-study, when Onivyde® in combination with 5-FU/LV is used in real-life practice in Belgium.
- Trial name
- NALIRI (NCT05095064)
- Testing
- Onivyde® + 5-FULV
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Antwerp
COVID-19 Acute Respiratory Distress Syndrome, Respiration, Artificial
Flow-controlled Ventilation (FCV) in Moderate Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19
Flow controlled ventilation (FCV) is a fairly new mode of mechanical ventilation, consisting of a constant inspiratory and expiratory flow. Inspiration is thus comparable to volume controlled ventilation (VCV).
- Trial name
- VICAR (NCT04894214)
- Testing
- Arterial blood gas (ABG), Recording of hemodynamic monitoring, Recording of respiratory monitoring
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- University Hospital, Antwerp
Healthy Volunteers
Biodistribution and Dosimetry of 99mTc-Duramycin
Conduct a first-in-human study in healthy volunteers to show safety, biodistribution and dosimetry of [99mTc]Duramycin.
- Trial name
- PicTURE (NCT05177640)
- Testing
- 99mTc-Duramycin
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Atelectasis
Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
The investigators hypothesize that the level of PEEP is often suboptimally applied in certain operative conditions, such as in laparoscopy with head down (Trendelenburg) positioning.
- Trial name
- optiPEEP (NCT04900714)
- Testing
- Decremental PEEP, Lung ultrasound score, Blood gas analysis
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Child
Pediatric Diaphragm Thickness Trial
The evaluation of diaphragm function in ventilated patients is not easy. One option is to use esophageal pressure (Pes) measurements but recently, diaphragmatic ultrasound has proven itself as a useful tool in this setting.
- Trial name
- PeDia (NCT04882553)
- Testing
- Diaphragmatic echography, Measurement of esophageal pressure, Registration of respiratory mechanics
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital, Antwerp