Clinical trials: sponsored by University Hospital, Bordeaux
Carcinoma, Non-Small-Cell Lung
Impact of a Radiologic and Immunologic Signature on Cerebral Efficacy of Treatments in Lung Cancers With Brain Metastasis
Non-small cell lung cancer frequently spreads to the brain, and brain metastases are associated with poor prognosis and limited treatment response.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Brain Neoplasms, Neoplasm Metastasis
- Trial name
- SIREC-Poumon (NCT07904013)
- Testing
- Radiomic analysis; Bulk RNA sequencing
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
The investigators want to evaluate ovarian reserve concerning patients with multiple sclerosis, compared to a control group of healthy women. This study will include women from 25 to 35 years old.
- Trial name
- FEMINISEP (NCT05754593)
- Testing
- Anti-Mullerian hormone (AMH) level, Antral follicle count (AFC), Clinical assessment
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis, Clinically Isolated Syndrome
Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis
The study aims at identifying the type of B and CD4 T cell subsets with pathogenic properties in the different clinical forms of multiple sclerosis.
- Trial name
- T4MS (NCT04798651)
- Testing
- blood sample, cerebro-spinal fluid
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Intensive Care
Implicit Bias in Intensive Care: Analysis and Assessment.
This study uses clinical vignettes to explore how healthcare professionals make complex ethical decisions in intensive care settings.
- Trial name
- BIRMAnie (NCT07886619)
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Colorectal Neoplasms
Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)
Colorectal cancer is a common and leading cause of death. Pre-cancerous lesions, as well as some so-called superficial cancers, can be resected via endoscopy.
- Trial name
- FORCE (NCT07871227)
- Testing
- Surgery, Radiochimiotherapy
- Where
- 14 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Bordeaux
Fabry Disease
Therapeutic Implications of CMR Low Native T1 in Non-treated Non-hypertrophic Females With Fabry Disease (FD)
Females with Fabry disease are characterized by variable phenotypes regarding time of onset, severity of symptoms and progression of disease due to the random inactivation of X chromosome leading to a cellular mosaic of mutated…
- Trial name
- NATI-Fab (NCT07872852)
- Testing
- Decision tree for initiating treatment
- Where
- 12 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders
Brain Iron in Beta-Propeller Protein Associated Neurodegeneration (BPAN)
This study aims to quantify intracerebral iron load in patients with Beta-Propeller Protein-Associated Neurodegeneration (BPAN) using Quantitative Susceptibility Mapping (QSM) technique.
- Conditions
- Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders, Brain Disease
- Trial name
- QUBIPAN (NCT07868120)
- Testing
- Standardized brain MRI including specific sequences usable for Quantitative Susceptibility Mapping (QSM)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Bordeaux
Restless Legs Syndrome
Functional Connectivity of the Interoceptive Network in RLS
Restless Legs Syndrome (RLS) is a sensorimotor disorder primarily characterized by an irresistible urge to move the legs while at rest.
- Trial name
- IntoRLS (NCT07001891)
- Testing
- Clinical assessment, auto-questionnaires (PSQI, ISI, ESS and HADS), Ecological Momentary Assessment (EMA)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Colonoscopy, Colorectal Neoplasms
Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.
The occurrence of interval cancers after colonoscopy raises the possibility of missed lesions. High- performance computer aided diagnosis (CAD) systems have been specially designed for the detection of colorectal lesions (CAD for…
- Conditions
- Colonoscopy, Colorectal Neoplasms, Intestinal Polyps
- Trial name
- IA-COLO 2 (NCT07299071)
- Testing
- Standard colonoscopy, Colonoscopy CADe
- Where
- 15 sites in France
- Volunteers
- 592 people
- Sponsor
- University Hospital, Bordeaux
Infections
Pharmacokinetics of Ertapenem in Patients Aged Over 75
In geriatric departments, physicians are faced with two difficulties, first the increasing number of infections caused by multiresistant bacteria, especially extended spectrum β-lactamase (ESBL) producing enterobacteria strains…
- Trial name
- PHACINERTA (NCT02505386)
- Testing
- Ertapenem
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Bordeaux
Obstructive Sleep Apnea (OSA)
Patient-Perceived Symptoms at the Center of Obstructive Sleep Apnea (OSA) Management: Validation of the French Version of the Patient-Reported Apnea Questionnaire (PRAQ)
Obstructive sleep apnea (OSA) is a common and disabling sleep disorder in which the assessment and monitoring of symptoms are central to patient management.
- Trial name
- PRAQ (NCT07836062)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Ventilator Acquired Pneumonia, Aspiration
Comparison of Two Strategies of Oropharyngeal and Tracheal Suctioning in Mechanically Ventilated Patients
The purpose of this study is to evaluate the impact of an optimized suctioning procedure on the risk of endotracheal microaspiration, measured by tracheal to oropharyngeal ratio of amylase enzymatic activity.
- Trial name
- AMYLASPI (NCT01807884)
- Testing
- Optimized oral care, Routine oral care
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bordeaux
Neovascular Age-related Macular Degeneration of All Subtypes
Assessment of Early Changes in SD-OCT After Initiation of a Treatment by Intravitreal Aflibercept (EYLEA®)START
Aflibercept (EYLEA®) induces a rapid reduction in central retinal thickness (CRT) for patients suffering from neovascular age-related-macular degeneration.1 This early dramatic reduction in CRT is already observed through week 4.
- Trial name
- START (NCT02246829)
- Testing
- Intravitreal injection
- Where
- 10 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Chronic Insomnia Disorder, Circadian Rhythm Disorders
Translation and Validation of the French Version of the Sleep Regularity Questionnaire: a New Tool to Address the the Challenge of Sleep Health
Sleep is an essential function for physical and mental health. The mismatch between biological rhythms and the social rhythms of individuals is increasingly common in modern societies.
- Trial name
- PRIMO (NCT06727448)
- Testing
- SRQ questionnaire
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Arthritis, Rheumatoid
Methotrexate and Metformin in Rheumatoid Arthritis Patients
Methotrexate (MTX) is the anchor drug for patients with rheumatoid arthritis (RA). Despite its marked efficacy and acceptable side effect profile, about 1/3 of patients failed to reach RA remission.
- Trial name
- METorMET² (NCT04196868)
- Testing
- Metformin treatment, Methotrexate treatment
- Where
- 12 sites in France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Bordeaux
Pressure Ulcers
Simplified Acute Physiology Score 2 and Pressure Ulcer Prediction in ICU.
Critically ill patients admitted in intensive care units are at high risk of developing pressure ulcer (also known as pressure injury).
- Trial name
- IGS-2-MIR (NCT07732517)
- Testing
- Pressure ulcer
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Bordeaux
Glaucoma
Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma
The EVOLUTION is a 10-year extension of the ENVOL study. It seeks to compare the evolution of structural and functional connectivity (Hub Disruption Index) and cerebral volume on 3T MRI of the brain in glaucoma patients and…
- Trial name
- EVOLUTION (NCT07802769)
- Testing
- MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Obesity (Disorder)
Characterisation of MNEsic Involvement in Patients With Obesity.
The aim of the study is therefore to characterise memory impairment in a middle-aged population with obesity and to clarify the role of inflammation in obesity-related memory impairment.
- Trial name
- MNEMOB (NCT07796932)
- Testing
- RMI and Questionnaires
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Acute Cystitis
Dispensing of Antibiotics in Pharmacies for Cystitis According to a Delegation Protocol, Impact of a Decision Support Tool. PHARIBO: PHarmacy and Resolved Antibiotherapy for Urinary Tract Infections
The purpose of this trial is to demonstrate that when treating acute cystitis without risk of complication, pharmacists may use share Decision Making tool to help patients to better understand the stakes of taking antibiotics and…
- Trial name
- PHARIBO (NCT07118748)
- Testing
- Share making decision tool, Delegation protocol
- Where
- 26 sites in France
- Volunteers
- 506 people
- Sponsor
- University Hospital, Bordeaux
Weaning From Mechanical Ventilation
Comparison of the Impact of Three Programs of Inspiratory Muscles.
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- PREDRIC (NCT02855619)
- Testing
- Martin, Cader, EDRIC
- Where
- 2 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Bordeaux