Clinical trials: sponsored by University Hospital, Bordeaux
Transgender Management Care
Gynaecological Care for Transgender People in France in 2024.
To date, the transgender population, still poorly characterized, tends to increase. The impact of gender-affirming hormone therapy (GAHT) in this population remains poorly understood, and few data are published on the…
- Trial name
- GyneTrans (NCT06357130)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 246 people
- Sponsor
- University Hospital, Bordeaux
Frailty, Cardiac Surgery
SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older
The hypothesis is that the preoperative Clinical Frailty Score (CFS) is a predictive factor for a loss in quality-adjusted life years (QALYs) one year after emergency cardiac surgery under cardiopulmonary bypass (CPB) in patients…
- Conditions
- Frailty, Cardiac Surgery, QALYs
- Trial name
- SAGE-Heart (NCT07677319)
- Testing
- Phone Calls
- Where
- France
- Volunteers
- 265 people
- Sponsor
- University Hospital, Bordeaux
Weaning From Mechanical Ventilation
Assessment of Inspiratory Muscles Strength and Endurance Evolution on Difficult to Wean Patients in Intensive Care Unit
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- EFES (NCT03140267)
- Testing
- Difficult to wean patients
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Premature Ovarian Failure
Evolution of Sexual Life Quality of Women With POI Before and After Introduction of Hormone Replacement Therapy
The aim of this study is to evaluate the evolution of quality of sex life of women with POI after introduction hormone replacement therapy through the FSFI scale
- Trial name
- SEX-POInt (NCT05890417)
- Testing
- questionnaire
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
MRI Hippocampal Microstructure and Episodic Memory in Early Multiple Sclerosis
Clinically isolated syndrome (CIS) can evolve into multiple sclerosis. In CIS patients, episodic memory is frequently impaired. Memory disorders could be preceded by microstructural abnormalities without visible atrophy in…
- Trial name
- Micro-MS (NCT03692975)
- Testing
- Clinical assessment, Neuropsychological evaluation, Psychological evaluation
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Acute Leukemia
Gynecological Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Adults
Gynecological impact and infertility are major issues for women after allogeneic hematopoietic stem cell transplantation. The aim of the present study is to investigate the prevalence of gynecological complications after…
- Trial name
- GYNEGRAFT (NCT07048730)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Bordeaux
Kidney Cancer
UroCCR Database: French Research Network for Kidney Cancer -UroCCR
Kidney cancer management has become increasingly complex with the diversification of treatment options and the integration of multidisciplinary care.
- Trial name
- UroCCR (NCT03293563)
- Testing
- Radical nephrectomy versus partial nephrectomy (according surgeon judgement)
- Where
- 68 sites in Belgium, France and 2 more
- Volunteers
- 30,000 people
- Sponsor
- University Hospital, Bordeaux
Renal Angiomyolipomas, Tuberous Sclerosis
Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers
Treatment of angiomyolipomas is based on invasive techniques such as surgery or embolization. Development of anti-angiogenic therapies is a major and growing field of research in hypervascularized tumors.
- Trial name
- STBETA (NCT02104011)
- Testing
- Propranolol
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Bordeaux
Osteogenesis Imperfecta, Rare Bone Disorders
Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis
MOSAIC aims to determine whether oro-dental morphological anomalies, particularly palatal morphology, associated with rare bone and cartilage diseases can be precisely characterized using 3D digital models analysed through…
- Conditions
- Osteogenesis Imperfecta, Rare Bone Disorders, Hypophosphatemia, X-Linked
- Trial name
- MOSAIC (NCT07666269)
- Testing
- intra-oral 3D optical impression
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Neurogenetic Diseases
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing
Nucleotide repeats emerge as one of the most prolific classes of genetic variations. They have the propensity to in-crease in length across generations, and have been implicated in at least 65 known neurological/…
- Trial name
- NRGEN-NGS3 (NCT07665554)
- Testing
- Skin biopsy, blood sampling
- Where
- 2 sites in France
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Intracranial Pressure, Critical Care
JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion
Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse.
- Trial name
- JUGULATE (NCT07665606)
- Testing
- Ultrasound assessment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
HIV-1-infection, Marker; Structural
SkIn, Muscle and Bone Aging Determinants in HIV Infected-patients.
this study consists of the study of markers of skin, muscular, neurocognitive and bone aging in HIV infected adults and to compare the frequency of these signs to the general population of same gender and age.
- Trial name
- SIMBAD (NCT04067219)
- Testing
- DXA (dual-energy x-ray absorptiometric) measurement
- Volunteers
- 123 people
- Sponsor
- University Hospital, Bordeaux
Papillomavirus Infections, Dysplasia
Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
- Conditions
- Papillomavirus Infections, Dysplasia, Cervix Cancer
- Trial name
- MMP-HPV (NCT04072913)
- Testing
- Vaginal samples (biopsies + vaginal smear)
- Where
- France
- Volunteers
- 216 people
- Sponsor
- University Hospital, Bordeaux
Drug-drug Interactions, Geriatric Disease
Impact of an Artificial Intelligence Platform on Inappropriate Medication Use in Older Adults
Polypharmacy in the older adults is common and promotes the risk of drug interactions. The hypothesis evoked is that a virtual platform with artificial intelligence applied to the health, and in particular to the good use of the…
- Trial name
- PING (NCT04710615)
- Testing
- Synapse platform
- Where
- 5 sites in France
- Volunteers
- 178 people
- Sponsor
- University Hospital, Bordeaux
Parkinson Disease, Multiple System Atrophy
Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis - Part 2
Parkinson's disease (PD) is the second most common neurodegenerative disease. Multiple system atrophy (MSA) is a relentlessly progressing rare neurodegenerative disease of unknown etiology.
- Trial name
- Voice4PD-MSA (NCT05807373)
- Testing
- voice recordings
- Where
- 2 sites in France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Groin Injury, Tendinopathy
Pubalgia and Adductor Tendinopathies Refractory to Medical Treatment
Pubalgia is a pain syndrome located in the groin area. This syndrome is mainly described in young male athletes and typically affect the superficial muscles defining the boundaries of the femoral triangle, i.e.
- Trial name
- PETRA (NCT03496649)
- Testing
- Dysport 500 Unit Powder for Injection
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinomas
Study of Metabolic Changes in the Transformation Malignant Precancerous Skin Lesions
Skin carcinomas are the most frequent cancers in the world, including basal cell carcinomas and cutaneous squamous cell carcinoma (cSCCs), with more than 60.000 new annual cases in France.
- Trial name
- MITOSKIN (NCT04389112)
- Testing
- biopsy
- Where
- France
- Volunteers
- 119 people
- Sponsor
- University Hospital, Bordeaux
Vitiligo, Skin Melanoma
Defining the Role of the Skin Microbiome in Immune-related Adverse Events
The skin microbiome has been implicated in several cutaneous autoimmune pathologies such as psoriasis and atopic dermatitis. However, its role in vitiligo and vitiligo lesions occuring in patients receiving anti-PD-1 for…
- Trial name
- SKINBIOTA (NCT04734704)
- Testing
- skin swabs at lesional and non-lesional sites, skin swabs on skin
- Where
- France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Bordeaux
Chronic Obstructive Pulmonary Disease
Analysis of the Dynamics of the Lung Microbiota During Acute Exacerbation of COPD Requiring Admission to Intensive Care Unit
This study aims to investigate the correlation between pulmonary microbiota dynamics (including bacteria, fungi and viruses) and COPD exacerbation for COPD patients admitted to ICU
- Trial name
- ADMiRE (NCT03641235)
- Testing
- Sputum collection
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Bordeaux
Anxiety, Surgery
Impact of a Double-reading Animated Film (Child, Parents) in Preoperative on the Anxiety of Children Upon Arrival at the Operating Room
Preoperative anxiety affects 40 to 60% of children. A literature review concluded that effective preparation strategies must involve parents, must be appropriate to their age and proposed upstream of the intervention.
- Conditions
- Anxiety, Surgery, Pediatric ALL
- Trial name
- VERAPOP (NCT04252508)
- Testing
- Animated film
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux