Clinical trials: sponsored by University Hospital, Brest
Ankle Injuries, Ligament Injury
Evaluation of Functional Outcomes at 2 Months According to Therapeutic Management, in Trauma With Low-grade Osteo-ligamentous Ankle Injury in Children
Lack of current consensus on the therapeutic management of low-grade osteo-ligament injuries in ankle trauma in children. Several types of immobilization are evaluated in the literature, with different conclusions.
- Trial name
- CHEVIPED (NCT05009342)
- Testing
- below-knee soft resin cast, Below-knee rigid resin cast
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Brest
Stroke, Ischemic, Stroke Hemorrhagic
Identification of Biomarkers in Ischemic Stroke - Clinical Trial
The objective of the study is to determine RNA blood biomarker based on 9 genes already identified in experimental studies, whose expression would be significantly increased in patient with ischemic stroke compared to controls.
- Trial name
- IBIS-CT (NCT04253275)
- Testing
- blood samples, MRI without injection
- Where
- France
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Patient Satisfaction
Unilateral Secondary Breast Reconstruction Using a Muscle-sparing Pedicled Dorsal Flap After Breast Cancer
The use of pedicled dorsal flaps sparing the latissimus dorsi muscle (TDAP and MSLD flap) is a well-described reconstruction method in breast reconstruction after breast cancer.
- Trial name
- RMSU-LDPEM (NCT06230250)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Brest
Venous Thromboembolism, Deep Vein Thrombosis
Venous Thrombo-Embolism Imaging Database (VTE-ID)
The purpose of this study is to identify and validate new imaging biomarkers allowing an individual phenotyping of patient with venous thrombo-embolism (VTE), mainly in terms of recurrence risk assessment and to distinguish…
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- VTE-ID (NCT06258694)
- Where
- France
- Volunteers
- 2,208 people
- Sponsor
- University Hospital, Brest
Cochlear Hearing Loss
Robotic and Manual Cochlear Implantation: An Intra-individual Study of Speech Recognition and Electrode Holder Position (ICRobMan)
Cochlear implantation (CI) allows rehabilitation for patients with severe to profound hearing impairment. Although the use of a robotic assistant provides technical assistance to the surgeon, the assessment of the impact of its…
- Trial name
- ICRobMan (NCT06235073)
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Cancer
Understanding and Anticipating Therapeutic Response And Immuno-meDIated Adverse Events in Anti-cancer Immune-checkpoint Inhibition: a Tissue Biopsy Based imaGing Study
Immune checkpoint inhibitors (ICI) have dramatically changed the management of some types of metastatic cancer, with indications for their use continuing to expand.
- Trial name
- TADIG-R (NCT05921123)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Pruritus, Psychogenic Skin Disease
Psychogenic and Neurogenic Components in Patients With Psychogenic or Neuropathic Pruritus
Scientific research on pruritus is in intensive development, with significant advances in understanding its pathophysiology. The causes of pruritus are very huge; they can be classified into different categories; we can find…
- Conditions
- Pruritus, Psychogenic Skin Disease, Neuropathic Pain, Itch
- Trial name
- PRURINEURO (NCT05024851)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Telecardiology
Safety Acceptability and Benefits of Tracking Cardiac Pacemakers by Carelink Express
Follow-up strategy for patients implanted with a pacemaker.
- Trial name
- SAFECARE (NCT03140150)
- Testing
- Follow-up by Carelink express, Follow-up according to the usual recommendations
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Tuberous Sclerosis Complex
Clinical Presentation and Renal Outcome of Patients With Tuberous Sclerosis Complex and/or Renal Angiomyolipoma in the Great West Region of France
This study aims to investigate the factors (clinical, care-related and genetic) affecting renal outcome in patients with TSC (Tuberous sclerosis complex)
- Trial name
- TSAR (NCT02887781)
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Venous Thromboembolism
REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism.
Patients with unprovoked venous thromboembolism (VTE) or VTE associated with persistent risk factors have a high risk of recurrence after stopping anticoagulation.
- Trial name
- RENOVE (NCT03285438)
- Testing
- Reduced dose of DOAC, Full dose of DOAC
- Where
- 39 sites in France
- Volunteers
- 2,774 people
- Sponsor
- University Hospital, Brest
Rheumatoid Arthritis
Pragmatic Study Comparing the Clinical Evlauation Methods ( C) and / or Ultrasound Method ( B or D) in Rheumatoid Arthritis to Adapt Treatment
This study compares different methods of clinical evaluation (C) and/or ultrasound (B or D) concerning the rheumatoid arthritis in order to monitore the treatment.
- Trial name
- BCD (NCT02410304)
- Testing
- Xrays, Ultrasound (B mode ), Ultrasound (D mode)
- Where
- 10 sites in France
- Volunteers
- 561 people
- Sponsor
- University Hospital, Brest
Superficial Temporal Artery
Imaging Study of Anatomical Variations of the Superficial Temporal Artery (EVATSI)
This study focuses on the anatomy of the superficial temporal artery, an artery of the head. Knowledge of the anatomy of this artery, and the evaluation of methods for exploring it, have implications for clinical medical and…
- Trial name
- EVATSI (NCT06155864)
- Where
- 2 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest
End Stage Renal Diseases
Evaluation of a Marine OXYgen Carrier for Organ Preservation
Preventing ischemia/reperfusion injuries (IRIs) is a major issue in kidney transplantation, particularly for transplant recipients receiving a kidney from extended criteria donors (ECD).
- Trial name
- OXYOP 2 (NCT04181710)
- Testing
- Kidney transplant
- Where
- 32 sites in France
- Volunteers
- 490 people
- Sponsor
- University Hospital, Brest
Polymyalgia Rheumatic (PMR)
BAriCitinib Healing Effect in earLy pOlymyalgia Rheumatica
Patients with recent PMR(6 months or less) with a PMR-AS >17 and no oral or parenteral GCs during the past 2 weeks (at least) will be included.
- Trial name
- BACHELOR (NCT04027101)
- Testing
- Baricitinib
- Where
- 8 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Brest
End Stage Renal Failure on Dialysis
ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial
This study is designed to etablish the effects of spironolactone in comparison to placebo on the composite endpoint of nonfatal Myocardial Infarction (MI) and acute coronary syndrome, hospitalization for heart failure, nonfatal…
- Trial name
- ALCHEMIST (NCT01848639)
- Testing
- Spironolactone
- Where
- 70 sites in Belgium, France and 1 more
- Volunteers
- 823 people
- Sponsor
- University Hospital, Brest
Recurrent Miscarriage, First Trimester Abortion
Hydroxychloroquine for Prevention of Recurrent Miscarriage.
Recurrent miscarriage (RM) defined by >=3 consecutive losses affects 1% of fertile couples. Most women have recurrent early loss with a failure of development before 10 weeks' gestation.
- Trial name
- BBQ (NCT03165136)
- Testing
- Hydroxychloroquine
- Where
- 18 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Patients in Complex Situations
A Quality Rating Scale for Patients in Complex Situations and Their Caregivers
Identify and analyze in the exercise groups coordinated (GECO) the effects of coordination arrangements between professionals on the transformation of modes of exercise of professional care, and on the experience of patients /…
- Trial name
- QualSoPrim (NCT02934711)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Hearing Loss, GJB2, Cis Regulation, DFNB1
Development Cellular Models of the Ear and Nose to Study the Mechanisms of Hearing
Development of cells culturesissued from Nose and Ear to study auditory mecanisms. Study of the cis-Modulation of the gene GJB2 for the patients with early presbycusis to identify the genetic cause of hearing loss.
- Trial name
- CMAG (NCT04823195)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Coronary Artery Disease, Coronary Microvascular Dysfunction
Multimodal Epicardial and Endocardial COronary PHYsiological Evaluation in Pathological Situations (PHYCO)
When performing coronary angiography in a stable situation, the identification of an intermediate coronary lesion (between 50 and 70%) is common, and requires additional functional evaluation.
- Trial name
- PHYCO (NCT06008041)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Brest
Distal Radius Fracture
Analysis of Implant Placement in Patients With Distal Radius Fractures in Western Brittany (REDIRA)
The purpose of this study was to determine the impact of design on plate position at the level of the distal radius. Six anterior wrist plates design were analyzed relative to the watershed line using the Soong classification.
- Trial name
- REDIRA (NCT06011122)
- Testing
- Distal radius fracture ORIF with a specific volar plate
- Where
- 5 sites in France
- Volunteers
- 2,723 people
- Sponsor
- University Hospital, Brest