Clinical trials: sponsored by University Hospital, Brest
Anesthesia
Evaluation of the Effectiveness of an Accelerated Rehabilitation Protocol Based on Multimodal Analgesia Optimization for Uni-compartmental Knee Prosthesis Surgery
Today, prosthetic replacement for osteoarthritis of the knee is a frequent surgery. In France, nearly 100,000 knee arthroplasties are performed each year .
- Trial name
- APUC (NCT04916158)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Blood Coagulation Disorder
Comparison of Two D-Dimers Dosing Techniques
Study of the possibility of substitution of the automated STAGO D-Dimers method with the semi-automated VIDAS method, which is more expensive, longer to implement and requires the use of a dedicated automaton.
- Trial name
- COMPADDI (NCT03972839)
- Where
- France
- Volunteers
- 3,027 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Ventilator Associated Pneumonia, Bacteremia
Intensive Care Unit Acquired Infections in Patients Colonized With Extended Spectrum Enterobacteriaceae
Worldwide emergence of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) had become a major problem in ICU, with at least 10% of incidence at the admission in Europe.
- Conditions
- Ventilator Associated Pneumonia, Bacteremia, Abdominal Infection, Enterobacteriaceae Infections
- Trial name
- BMREA (NCT04903886)
- Testing
- observational
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Brest
Pregnancy Preterm
Evaluation of Vaginal PAMG-1 Detection by PartoSure Test in Preterm Delivery Threat in Actual Clinical Situation: Randomized Controlled Trial
Prematurity is defined as birth before 37 weeks of amenorrhea. It is the leading cause of perinatal morbidity and mortality. It is estimated that premature births to 15 million worldwide in 2010, including 60,000 children in…
- Trial name
- PARTO-MAP (NCT03675061)
- Testing
- Current care, PartoSure Test negative, PartoSure Test positive
- Where
- France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Brest
NSCLC
Real Life Second-Line Nivolumab in Advanced Non-Small Cell Lung Cancer
Data regarding nivolumab as second line treatment in advanced non-small cell lung cancer (NSCLC) are based on selected populations and might not reflect daily practice.
- Trial name
- IMMUNOBZH (NCT04858204)
- Where
- 7 sites in France
- Volunteers
- 259 people
- Sponsor
- University Hospital, Brest
Traumatic Brain Injury
Prediction of Secondary Neurological Deterioration in Patients With Moderate Traumatic Brain Injury
Patients with moderate traumatic brain injury (mTBI) are 1,5 times more frequent than those with severe TBI and some of them will develop secondary neurologic deterioration (SND) within the first 7 days.
- Trial name
- PREDICT-TCM (NCT04854954)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Brest
Prematurity
Family-centered Round in Neonatology
The family-centered care is based on dignity and respect, information sharing, collaboration and participation in care and decision-making.
- Trial name
- VINCI (NCT04852094)
- Testing
- Qualitative focus group
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Occupational Stress
Staff Physical and Mental Health Assessment in the Aftermath of the First Peak of the Covid-19 Outbreak
Objectives: This study compare the mental health impact and psychosocial perception of healthcare workers and non healthcare workers in hospital after the first peak of COVID-19 outbreak in France.
- Trial name
- SAMAF (NCT04849546)
- Where
- France
- Volunteers
- 1,491 people
- Sponsor
- University Hospital, Brest
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Clinical and Molecular Description of PKD1 and PKD2 Mutation Negative Carriers in ADPKD
The aim of this study is to identify families with ADPKD , characterize the phenotype and screen for mutations in known genes (PKD1 and PKD2, and then HNF1b and UMOD in PKD1 PKD2 negative carriers).
- Trial name
- GeneQuest (NCT02112136)
- Testing
- Blood Collection
- Where
- 25 sites in France
- Volunteers
- 1,450 people
- Sponsor
- University Hospital, Brest
Cardiovascular Risk Factor
Community Champions Included in the SPICES Project: Study of Facilitators and Barriers to Their Participation in Support Groups for the Primary Prevention of Cardiovascular Risk Factors: (EFFPCA)
In 2017, cardiovascular diseases (CVDs) were the leading cause of death worldwide. Most cardiovascular diseases can be prevented by changing risk behaviors.
- Trial name
- NCT04749550
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Brest
Advanced Hepatocellular Carcinoma
ATEZOLIZUMAB - BEVACIZUMAB in the Treatment Hepatocellular Carcinoma Inoperable or
Evaluation of the efficacy and safety of the combination ATEZOLIZUMAB - BEVACIZUMAB in the treatment of locally advanced inoperable or metastatic hepatocellular carcinoma in Finistère
- Trial name
- HEPATOFIT (NCT04730388)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Chronic Lymphoid Leukaemia
Chronic Lymphoid Leukaemia Observatory in Finistere Area, France
Brief Summary: The purpose of the OFICE registry is to characterize and describe the CLL patients' population from the Finistere area and evaluates the association between different patient characteristics, prognosis and…
- Trial name
- OFICE (NCT03294980)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Brest
Endodontic Disease
Effect of Music on Young Practitioner's Stress During Endodontic Treatment
According to several studies, patients consider endodontic treatment as one of the most stress-inducing dental procedures. Two studies demonstrated that music enables the patient to be less stressed during RCT.
- Trial name
- MUSIQUENDO (NCT04471558)
- Testing
- Music
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Aneurysmal Disease, Stroke
Prediction of Patient-specific Outcomes After Interventional neuroRadiology Procedures
Stroke is either an obstruction (ischemic stroke) or the rupture of a blood vessel in the brain (ruptured aneurysm). It can happen at any age in adults.
- Trial name
- PREDICTNRI (NCT04504695)
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Brest
COPD
Pulmonary Rehabilitation and Self-esteem in Patients With COPD
the aim of this study is to evaluate the evolution of self-esteem during a pulmonary rehabilitation program, in COPD patients.
- Trial name
- ESMOI (NCT04172155)
- Where
- 2 sites in France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Brest
Myelodysplastic Syndromes, Myelodysplastic Syndrome With Isolated Del(5Q)
Haploinsufficiency of the RBM22 and SLU7 Genes in Del(5q) Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are malignant hematopathies of the elderly characterized by persistent cytopenias and the presence of deregulated clonal hematopoiesis.
- Conditions
- Myelodysplastic Syndromes, Myelodysplastic Syndrome With Isolated Del(5Q), Myelodysplastic Syndrome With Del(5Q)
- Trial name
- SMD-RMB22 (NCT04701229)
- Testing
- somatic cytogenetic and genetic characterization
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Polymyalgia Rheumatica
Safety and Efficacy of tocilizuMAb Versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence SEMAPHORE
Patients are treated with infusions of Tocilizumab (TCZ) or placebo for 5 months. Clinical evaluation is performed using PMR-AS.
- Trial name
- NCT02908217
- Testing
- Tocilizumab
- Where
- 17 sites in France
- Volunteers
- 113 people
- Sponsor
- University Hospital, Brest
Venous Thromboembolism
Impact of Early Debriefing and Enhanced Educative Components on Direct Oral Anticoagulant Adherence After Venous Thromboembolism.
Venous thromboembolism (VTE) is a frequent multifactorial and potential life-threatening disease. Once VTE has been diagnosed, anticoagulation should be started and prolonged for at least three to six months in order to reduce…
- Trial name
- DEBRIEF-VTE (NCT04141254)
- Testing
- Debriefing and educative components, Without debriefing and educative components
- Where
- 10 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Itch
Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging.
The main objective of this study is to identify by functional and structural MRI which are the brain areas activated in various pruritic situations to deduct a model describing the different causes of pruritus.
- Trial name
- PRURIM (NCT02828787)
- Testing
- MRI
- Where
- 2 sites in France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Premature Ejaculation
Consultations Reason for Genital, Urinary or Psychological Humans in General Practice
Many male patients complain about their ejaculation: 21-30% of men aged between 18 and 59 have admitted suffering from a decrease in, or loss of control of, their ejaculation.
- Trial name
- GETUP (NCT02378779)
- Testing
- Questionary SF12 and PEDT (Premature Ejaculation Diagnostic Tool), Total attention, Humour
- Where
- 23 sites in France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Brest