Clinical trials: sponsored by University Hospital, Brest
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the bronchi with an increasing prevalence. By 2020, the mortality related to COPD is expected to become the 3rd leading death worldwide.
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Smoking
- Trial name
- SAVE (NCT01694732)
- Testing
- Varenicline
- Where
- 13 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Brest
Sjogren's Disease
Evaluation of the Reproducibility Inter-observer of the Ultrasound Anomalies of the Salivary Glands in Sjogren's Disease
This aim of this study is to compare the reproducibility of reading of five international experts concerning the anomalies of the salivary glands. The reproducibility is measure on patients and not on recorded data.
- Trial name
- ETREINTE (NCT02358213)
- Testing
- Ultrasound
- Volunteers
- 21 people
- Sponsor
- University Hospital, Brest
Indication of Blood Gas Analysis by Radial Artery Blood Sampling
Local Anesthesia Before Arterial Puncture for Blood Gas Analysis
The aim of the study is to evaluate the interest of Local Anesthesia (lidocaïne/prilocaïne versus placebo)before arterial puncture for Blood Gas Analysis.
- Trial name
- GAEL (NCT01964248)
- Testing
- lidocaïne/prilocaïne 5%
- Where
- France
- Volunteers
- 136 people
- Sponsor
- University Hospital, Brest
Cerebral Lymphoma B Cell Refractory
Phase II Study Evaluating a Combination of Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy With High Dose Methotrexate (MTXHD) and / or High-dose Cytarabine.
The protocol is to assess the overall response rate (complete response and partial response) of treatment with non-pegylated liposomal doxorubicin at a dose of 50 mg / m² in combination with dexamethasone in immunocompetent adult…
- Trial name
- MYLY (NCT01848652)
- Testing
- infusion of MYOCET
- Where
- 3 sites in France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Brest
Alive and Viable Births
Prevention of Unexplained Recurrent Abortion by Enoxaparine
Standard investigations fail to reveal any apparent cause in 50% of the cases of recurrent spontaneous abortion. Prothrombotic mechanisms were initially evoked.
- Trial name
- PREFIX (NCT00740545)
- Testing
- enoxaparine 40 mg daily
- Where
- 7 sites in France
- Volunteers
- 258 people
- Sponsor
- University Hospital, Brest
Polymyalgia Rheumatica
Tocilizumab Effect iN pOlymyalgia Rheumatica
Phase 1: Patients are treated with infusions of Tocilizumab (TCZ) for 3 months. Clinical evaluation is performed using PMR-AS. The PMR-AS is computed by summing the 5 variables after multiplying by 0.1 for weighting purposes…
- Trial name
- TENOR (NCT01713842)
- Testing
- TCZ
- Where
- 3 sites in France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Brest
No High Risk of Hemorrhage
Efficacy of the Association Mechanical Prophylaxis + Anticoagulant Prophylaxis on Venous Thromboembolism Incidence in Intensive Care Unit (ICU)
This multicentre open-label randomized parallel-group trial aims to compare the association of intermittent pneumatic compression of the lower limbs + elastic stockings + anticoagulant prophylaxis to anticoagulant prophylaxis…
- Trial name
- CIREA2 (NCT00740987)
- Testing
- Intermittent pneumatic compression of the lower limbs
- Where
- 15 sites in France, Monaco
- Volunteers
- 621 people
- Sponsor
- University Hospital, Brest
Thromboembolism, Unspecified Adult Solid Tumor, Protocol Specific
Standard Diagnostic Procedures With or Without Fludeoxyglucose F 18 Positron Emission Tomography in Finding Cancer in Patients With a Blood Clot in a Vein
RATIONALE: Diagnostic procedures, such as fludeoxyglucose F 18 positron emission tomography, may help find and diagnose cancer. It is not yet known whether standard diagnostic procedures are more effective when given with or…
- Trial name
- MVTEP (NCT00964275)
- Testing
- diagnostic procedure, fludeoxyglucose F 18
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Brest
Acute Respiratory Distress Syndrome, Hypoxemia
Automatic Administration of Oxygen During Respiratory Distress
Aim: The purpose of this study is to evaluate the use feasibility of FreeO2 so as to deliver automatically oxygen in the emergency department in a patient population admitted for acute respiratory failure.
- Trial name
- FreeO2-Hypox (NCT02027181)
- Testing
- Device FreeO2 v2.0
- Where
- 4 sites in Canada, France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Brest
Indication for Renal and/or Adrenal Surgery
Merits of Continuous Paravertebral Block in the Management of Renal/Adrenal Surgery by Laparotomy
The paravertebral block is an alternative in the analgesia epidural the major interest of which lives in the catheterisation of the paravertébral space allowing to assure/insure an one-sided continuous analgesia.
- Trial name
- BPV (NCT01023854)
- Testing
- Continuous Paravertebral block
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Brest
Renal Transplant
mTor-inhibitor (EVERolimus) Based Immunosuppressive Strategies for CNI Minimisation in OLD for Old Renal Transplantation
This study is designed to evaluate efficacity and safety of everolimus or (cyclosporine then everolimus) vs. cyclosporine as immunosuppressive treatment in renal transplantation for elderly (>60 years old) recipients receiving…
- Trial name
- EVEROLD (NCT01028092)
- Testing
- Anti R-IL2 + Cyclosporine, Thymoglobulin + Everolimus, Anti R-IL2 + Cyclosporine then Everolimus
- Where
- 18 sites in France
- Volunteers
- 327 people
- Sponsor
- University Hospital, Brest
Rotavirus Gastroenteritis
Impact of Systematic Infants Vaccination Against Rotavirus on Gastroenteritis Hospitalization: a Prospective Study in Brest District, France.
Universal rotavirus vaccination program for infants born in Brest after February 2007, applied by the Centers for Maternal and Infant Health Protection, pediatricians and general practitioners.
- Trial name
- IVANHOE (NCT00740935)
- Testing
- Rotateq vaccine
- Where
- France
- Volunteers
- 7,204 people
- Sponsor
- University Hospital, Brest
Hip Fracture
Statin in Hip Fracture
Statins (or HMG-CoA reductase inhibitors) have largely proven their efficacy in the primary and secondary prevention of cardiovascular events.
- Trial name
- STAFF (NCT01494090)
- Testing
- Rosuvastatin
- Where
- 6 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Brest
Forearm and Arm Surgery
Comparison Between Two Different Volumes of Anesthesia Drug in Forearm Surgery
Hospitalized patients for superior member surgery have different types of anesthesia.Forearm and/or arm surgery could be done under general anesthesia, but in the most of the cases, this surgery was done under locoregional…
- Trial name
- COMBAX (NCT01216488)
- Testing
- Xylocaine
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Brest
Autistics Children
Efficiency of Bumetanide in Autistic Children
The purpose of this study is to determine if a treatment by bumetanide presents an efficiency at the level of the neuronal maturation in the autism
- Trial name
- BUMEA (NCT01078714)
- Testing
- bumetanide
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Brest
Pericarditis
Benign Acute Pericarditis: Brief Versus Longer Treatment Using Aspirin
Treatment of pericarditis largely remains empirical due to the relative lack of randomized controlled trials. Nevertheless, some recommendations have been formulated to guide management and follow-up of acute pericarditis.
- Trial name
- pericardite (NCT00946907)
- Testing
- Aspirin
- Where
- 12 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism
V/Q SPECT for Diagnosis of Pulmonary Embolism
The objective of the study was to assess diagnostic performance of V/Q SPECT for the diagnosis of pulmonary embolism by comparing V/Q SPECT results to a validated diagnostic strategy.
- Trial name
- NCT01183026
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Sepsis
Mild Therapeutic Hypothermia During Severe Sepsis
Objectives: to evaluate the feasibility, the safety and the effects on physiological parameters of mild therapeutic hypothermia during septic shock. Design: a randomized, controlled, pilot physiological study.
- Trial name
- NCT01069146
- Testing
- Mild therapeutic hypothermia induction
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Lung Cancer
Pemetrexed Plus Cisplatin for Brain Metastasis of Advanced Non - Small Cell Lung Cancer (NSCLC)
NSCLC patients often have cerebral metastasis : 10% at diagnosis and 40% during disease management. Neurosurgery is not indicated in the majority of cases because of presence of several lesions in the brain, failure of primary…
- Trial name
- GFPC 07-01 (NCT00744900)
- Testing
- Pemetrexed, cisplatin
- Where
- 25 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Brest
Lung Neoplasm
Oral Vinorelbine and Cisplatin and Concurrent Radiotherapy After Induction Chemotherapy in Locally Advanced NSCLC.
Our aim is to conducted a multicenter phase II trial of the cisplatin-oral vinorelbine -radiotherapy combination after induction chemotherapy with cisplatin-docetaxel in patient with NSCLC.
- Trial name
- VINCR (NCT00295672)
- Testing
- Vinorelbine
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Brest