Clinical trials: sponsored by University Hospital, Brest
Myeloproliferative Disorder, Aquagenic Pruritus
Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasms
Phase 3, randomized prospective study, double blind-double placebo, testing oral therapies APREPITANT versus HYDROXYZINE in patients followed for myeloproliferative neoplasms and suffering of persistent aquagenic pruritus.
- Trial name
- APHYPAP (NCT03808805)
- Testing
- Aprepitant 80 mg, Hydroxyzine 25mg
- Where
- 11 sites in France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism
Pulmonary Perfusion by Iodine Subtraction Mapping CT Angiography in Acute Pulmonary Embolism
Pulmonary embolism (PE) is a diagnostic and therapeutic challenge. The risk of death of untreated PE is approximately 25%. On the other hand, anticoagulant treatment is associated with a haemorrhagic risk (2% of major…
- Trial name
- PASEP (NCT03579849)
- Testing
- Pulmonary tomoscintigraphy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
High Bleeding Risk, Hemorrhage
Efficacy of Intermittent Pneumatic Compression (IPC) on Venous Thromboembolism Incidence in Intensive Care Unit (ICU) Patients With High Bleeding Risk
This multicentre open-label randomized parallel-group trial aims to evaluate the association intermittent pneumatic compression + elastick stockings versus elasting stockings alone on symptomatic or asymptomatic venous…
- Trial name
- CIREA1 (NCT00740844)
- Testing
- Intermittent pneumatic compression of the lower limbs
- Where
- 10 sites in France
- Volunteers
- 408 people
- Sponsor
- University Hospital, Brest
Arthroplasty, Replacement, Hip
Pelvic Inclination Measurement by Navigated Ultrasound
Prospective, multicenter, non-randomized study. Primary endpoint : to confirm the proper functioning of the device in vivo by analyzing intra and interobserver reproducibility of repeated measurements on healthy controls.
- Trial name
- MIPEN (NCT03555812)
- Testing
- Pelvic inclination measurement
- Where
- 2 sites in France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Sensitive Skin
Study of the Efficacy and Tolerance of Light Therapy in Sensitive Skin
Light-emitting diode (LED) light therapy is increasingly used successfully and without adverse effects in diabetic leg ulcer, chronic low back pain, chronic myofacial pain in the neck and in several dermatoses such as acne…
- Trial name
- SENSILED (NCT03279003)
- Testing
- LED light
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Diabetic Neuropathy
Evaluation of Rocker sOles in Diabetis
The purpose of this study is to determine if the wearing of shoes "rocker sole" type prescribed in type 2 diabetics patients with neuropathy are responsible for disorders of equilibrium.
- Trial name
- EROD (NCT02891928)
- Testing
- Rocker sole shoes, Normal shoes
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Brest
Prevention of the Suicide
Short Message System (SMS) for Caregivers of Suicidal Patients to Prevent Recidivism of Suicide Attempts
Assessment of the feasibility of a monitoring device by SMS in which messages are sent by the caregiver after a suicidal act.
- Trial name
- C-SIAM (NCT03069560)
- Testing
- SMS
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
The Six-minute Stepper Test as an Outcome Measure of Exercise Tolerance During Pulmonary Rehabilitation in With Chronic Obstructive Pulmonary Disease (COPD) Patients(STEPPER)?
The aim of this study is to show if the six-minute stepper test (ST6) is a sensible marker of exercise tolerance evolution during a pulmonary rehabilitation program in people with all stages of severity of Chronic Obstructive…
- Trial name
- STEPPER (NCT01759199)
- Testing
- Pulmonary rehabilitation assessed with six-minute walk test and six-minute stepper test
- Where
- 3 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Brest
Hyperhidrosis
Treatment of Hyperhidrosis With Oxybutynin
Evaluation of the effectiveness of oxybutynin in hyperhidrosis
- Trial name
- H²O (NCT01855256)
- Testing
- Oxybutynin
- Where
- 4 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Brest
Diabetes Type 1
Comparison of Insulin's Injection Before or After the Meal in Type 1 Diabetic Patients Treated With Insulin Pump
The current study focuses on terms of use of Insulin Aspart, fast analogue of human insulin and commonly used in the treatment of type 1 diabetes, where it obtained the marketing authorization for this indication.
- Trial name
- BOLUS (NCT02546401)
- Testing
- Insulin Aspart
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Brest
Anterior Cruciate Ligament Injuries
Influence of Proprioceptive Reweighting Ability on Lower-limb Biomechanics During Functional Tasks
Anterior cruciate ligament (ACL) injuries are frequent in handball especially among young players. Recent investigations highlighted the implication of the central nervous system as a potential risk factor for ACL rupture.
- Trial name
- NEURIBIO (NCT04736511)
- Testing
- Star Excursion Balance Test, Single leg Drop Vertical Jump, Unplanned sidestep cutting manoeuvre
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease, Patients Hospitalized for a COPD Exacerbation
Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
A standardized diagnostic strategy of pulmonary embolism will be applied to eligible patients, incorporating a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a multidetector-row CT…
- Trial name
- PEP (NCT02035293)
- Testing
- PEP
- Where
- 7 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
Effects of Inspiratory Muscle Training on Dyspnea in Subjects With Chronic Obstructive Pulmonary Disease
The purpose of this study is to determinate whether inspiratory muscle training (IMT) associated with a conventional respiratory rehabilitation program is more effective than a conventional respiratory rehabilitation program…
- Trial name
- IMT (NCT01545011)
- Testing
- Inspiratory muscle training
- Where
- 2 sites in France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Brest
Surgery for Primary Lung Cancer
Non-Invasive Ventilation Preoperative Lung Resection Surgery
Surgical treatment is the standard treatment for localized forms of lung cancer non-small cell. It allows a 5-year survival exceeding 50% for complete resection of the tumor.
- Trial name
- préOVNI (NCT01685580)
- Testing
- Manufacturer (VPAP ST)
- Where
- 15 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
COPD
Effect of Neuromuscular Electrical Stimulation Versus Cycle Ergometer Training in a Pulmonary Rehabilitation Program
The aim of this study is to evaluate the effectiveness of quadriceps strengthening with neuromuscular electrical stimulation versus cycle ergometer as part of pulmonary rehabilitation program , in patients with severe or very…
- Trial name
- ESNM (NCT02656667)
- Testing
- neuromuscular electrical stimulation, cycle ergometer training, Conventional pulmonary rehabilitation
- Where
- 2 sites in France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Brest
Depression
Validation of the French Translation of the Scale HSCL25 in the Diagnosis of Depression in Primary Care
Depression has emotional consequences, social and important business. Reaching at least 7.5% of French aged 15 to 85 years. General Practitioners are the first professional consulted in terms of frequency of consultations.
- Trial name
- HSCL25 (NCT02414711)
- Testing
- HSCL25 scale, PSE9 questionary
- Where
- 3 sites in France
- Volunteers
- 1,128 people
- Sponsor
- University Hospital, Brest
Venous Thromboembolism
Shared Decision-making Process for Unprovoked vEnous THromboEmbolism Management. (ETHER )
Venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) is a frequent disease and the third most common cause of cardiovascular death in the world after myocardial infarction and stroke.
- Trial name
- ETHER (NCT06731244)
- Testing
- Usual Care Group, shared decision-making process
- Where
- 20 sites in France
- Volunteers
- 2,400 people
- Sponsor
- University Hospital, Brest
Severe Postpartum Hemorrhage
Detection of Bleeding Disorders Diagnosed After Vaginal Delivery Complicated by Severe Postpartum Hemorrhage
A cohort study designed to detect bleeding disorders diagnosed in women who experienced severe postpartum hemorrhage after vaginal delivery
- Trial name
- DIDAPPH (NCT06970860)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
COPD
Interest of Performing Two 6-minute Walk Tests at the End of a Pulmonary Rehabilitation Program, in COPD Patients.
In pulmonary rehabilitation, the 6-Minute Walk Test (6MWT) is essential to assess the effects of the program on patients' health. Current guidelines don't recommend to perform two 6MWT at the end of pulmonary rehabilitation.
- Trial name
- 2-TM6 (NCT05850299)
- Where
- France
- Volunteers
- 176 people
- Sponsor
- University Hospital, Brest
Septic Shock
Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock
Many observational studies have highlighted an independent association between fluid overload and clinical outcomes during septic shock.
- Trial name
- GOAL (NCT03461900)
- Testing
- Minifluid challenge, Usual practice
- Where
- 18 sites in France
- Volunteers
- 535 people
- Sponsor
- University Hospital, Brest