Clinical trials: sponsored by University Hospital, Brest
Chronic Periodontitis, Aggressive Periodontitis
B Cell Functions in Periodontitis
The inflammatory response involves many players from the immune response, including B lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to the presence of an antigen.
- Trial name
- LBPARO (NCT02833285)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Non-small-cell Lung Cancer
PEmbRolizumab verSus chEmotherapy and pEmbrolizumab in Non-small-cell Lung Cancers (NSCLC) With PDL1 ≥ 50 %
PERSEE is a French national phase 3 academic study comparing the chemotherapy-pembrolizumab combination to pembrolizumab alone as a first-line treatment for advanced NSCLC molecularly defined by a PDL1 expression ≥ 50% of tumour…
- Trial name
- PERSEE (NCT04547504)
- Testing
- Pembrolizumab, Pembrolizumab and Chemotherapy drugs
- Where
- 29 sites in France
- Volunteers
- 349 people
- Sponsor
- University Hospital, Brest
COPD (Chronic Obstructive Pulmonary Disease), Caregiver
Validation of the French Version of the QASCI in Caregivers of Patients With COPD
This study aims to validate the French version of the QASCI questionnaire, initially written and validated in Portuguese language by Hipolito et al., to assess caregiving burden in chronic obstructive pulmonary disease (COPD).
- Trial name
- VALQASCI (NCT06652204)
- Testing
- questionnaire
- Where
- 2 sites in France
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
The Translation of a Screening Tool
French Translation of The Female Sexual Distress Scale-Revised
Two independent teams (Brest and Nice) each produce a forward translation from English to French. The translations are compared, and discrepancies are discussed with the translation coordinator, the second translator, and the…
- Trial name
- f-FSDS-R (NCT07090239)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Coronary Artery Disease
Assessment of Quitting Versus Using Aspirin Therapy In Patients Treated With Oral Anticoagulation for Atrial Fibrillation or Other Indication With Stabilized Coronary Artery Disease
Long-term aspirin (ASA) is the standard recommended antithrombotic therapy in patients with stable coronary artery disease (CAD), especially following stenting (Class I, Level A).
- Trial name
- AQUATIC (NCT04217447)
- Testing
- OAC + Aspirin 100mg od
- Where
- 51 sites in France
- Volunteers
- 874 people
- Sponsor
- University Hospital, Brest
Neuroendocrine Tumors
Whole Body Dynamic 68Ga-DOTATOC PET/CT in Neuroendocrine Tumors
Neuroendocrine tumors (NET) are a network of rare tumors with common embryological origin. Functional imaging plays a major role in the extension assessment and tumor characterization of NETs.
- Trial name
- GAPET-NET (NCT03576040)
- Testing
- Whole Body Dynamic 68Ga-DOTATOC PET/CT
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Brest
Colo-rectal Cancer
Multiparametric Characterization of Colorectal Cancers (METRAD)
The primary goal of this observational study is to assess the predictive value of a model developed through a multiparametric analysis of clinical images, histopathological data, CT scans, and molecular analysis.
- Trial name
- METRAD (NCT07000474)
- Testing
- Omics
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Intensive Care Unit (ICU) Patients, Metastatic Cancer
Study of Interactions Between Oncologists and Resuscitators to Optimize Decision Making for Admission of Patients With Metastatic Solid Cancer to the ICU (InterOncoRea)
The aim of our study is to optimise the interaction between oncologists and resuscitators to improve decision-making regarding the admission of patients with metastatic solid cancers to the ICU.
- Trial name
- InterOncoRea (NCT06993987)
- Testing
- Descriptive analysis
- Where
- France
- Volunteers
- 139 people
- Sponsor
- University Hospital, Brest
Uterine Anteflexion
Prospective Study of the Variation in the Angle of Anteflexion of the Uterus Before and After Micturition in Nulliparous Women With Uterine Anteversion.
A monocentric, prospective, comparative, and descriptive clinical study examining the uterine anteflexion angle before and after bladder emptying in nulliparous women with uterine anteversion.
- Trial name
- FLEXIMIX (NCT06669845)
- Testing
- Ultrasonography, Pelvic
- Where
- France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Chest Trauma, High Flow Oxygenation
Management of Moderately Hypoxemic Thoracic Trauma
In France, the average incidence of thoracic trauma is 10,000 to 15,000 each year. These patients are at risk of early and late post traumatic respiratory complications as follows: pneumonia, Acute Respiratory Distress Syndrome…
- Trial name
- TrOMaTho (NCT03997630)
- Testing
- High flow Oxygenation, Standard oxygen
- Where
- 18 sites in France
- Volunteers
- 770 people
- Sponsor
- University Hospital, Brest
HPV, HPV Vaccination
Impact of Catch-up HPV Vaccination
Each year in France, more than 6000 new cases of HPV inducted cancers are recorded. The vaccinal cover stays insufficient since less than 30% of the french population is vaccinated.
- Conditions
- HPV, HPV Vaccination, Vaccine Preventable Disease, Cervical Lesion
- Trial name
- HPVAC2 (NCT05462249)
- Where
- France
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Alopecia, Lichen Planus
Study of the Characteristics of Pruritus in Patients With Frontal Fibrosing Alopecia or Lichen Planus Pilaris
The prevalence of pruritus has been studied in frontal fibrosis alopecia (FFA) and lichen planus pilaris (LPP), but there are no studies evaluating the characteristics of pruritus, the correlation between pruritus and disease…
- Trial name
- PRURIT-ALOPECI (NCT05761158)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Brest
Nurses, Operating Rooms
Working With Your Body in the Operating Room. The Case of Operating Room Nurses (RCIBO)
The undocumented observation, repeatedly observed in the operating rooms, of discomfort, including fainting, among medical and paramedical novices working in contact with surgical breaches raises questions about the mechanisms…
- Trial name
- RCIBO (NCT06938594)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Prosthesis Failure
Medium-term Results of the LPS™ System for Segmental Resection of the Distal Femur, a Multicenter Retrospective Study (RESIF)
The reconstruction of the distal femur using modular systems has become increasingly popular over the years, surpassing primary arthrodesis or amputation.
- Trial name
- RESIF (NCT06928948)
- Testing
- Femur replacement
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Brest
Transplantation, Pulmonary Diseases
Specific Genotypes/Phenotypes of Pneumocystis Jirovecii in Solid Organ Transplant Recipients: Potential Involvement of Mycophenolic Acid
To determine the presence of IMDPH mutants of Pneumocystis jirovecii in solid organ transplant recipient with prior exposition to mycophenolic acid.
- Trial name
- IMPDH (NCT05452148)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Chronic Stroke Patients
Stroke Patients' Preferences for an Exoskeleton for Lower Limb Rehabilitation Using the DCE Method (EXOPREF)
The main aim of this study is to investigate the preferences of individual stroke patients for key features of an exoskeleton, intended for lower limb rehabilitation, with a view to its potential integration into the design of…
- Trial name
- EXOPREF (NCT06921031)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Brest
Enterovirus Infections, Meningitis, Viral
Molecular Epidemiology of Enteroviruses Detected at the Virology Laboratory of Brest University Hospital During the Period 2018-2024: Retrospective Analysis of an Atypical Meningitis Epidemic in 2024 (BrEcho9Men)
This study is being done to learn more about enterovirus infections detected in the cerebrospinal fluid of patients at CHU de Brest. Researchers will analyze medical records and laboratory data collected between 2018 and 2024.
- Conditions
- Enterovirus Infections, Meningitis, Viral, Meningitis Enterovirus, Echovirus 9
- Trial name
- BrEcho9Men (NCT06922474)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Brest
Congestion, Venous
Hepatic Doppler to Assess Venous Congestion During Invasive Mechanical Ventilation (DOHECOV)
The purpose of the study is to investigate venous congestion using hepatic vein doppler for ICU patients with invasive mechanical ventilastion. The primary outcome is the systolic to diastolic hepatic vein velocity ratio S/D .
- Trial name
- DOHECOV (NCT06914336)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Equinus Deformity
Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral Palsy
This research will lead to the first evaluation of intrinsic and dynamic joint and muscle mechanics of equinus in cerebral palsy. It would provide a direct cause and effect relationship between equinus and bone deformity.
- Trial name
- EQUINUS (NCT02814786)
- Testing
- MRI scanner, Gait analysis
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Inflammation; Skin, Psoriasis
Pleiotropic Role of TRPV1 in Psoriasis Inflammation
Widely expressed in the sensory nerve endings of the skin, Transient Receptor Potential Vanilloid 1 (TRPV1) is a receptor that plays an important role in the perception of pain and pruritus but also in skin inflammation…
- Trial name
- TRIP (NCT04848194)
- Testing
- skin biopsy and blood sampling
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Brest