Clinical trials: sponsored by University Hospital, Caen
Peripheral Arterial Disease
Analysis of Arterial Waveforms and Oxygen Pressure During Supervised Exercise for Peripheral Artery Disease
The goal of this observational study is to assess the evolution of oxygen pressure and arterial waveform during supervised exercise therapy in patients with peripheral arterial disease.
- Trial name
- WAVESUPEX (NCT05818046)
- Testing
- transcutaneous oxygen pressure, Supervised Exercise therapy
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Caen
Critical Illness
Evaluate the Relevance of the Use of Peripheral Venous Blood Gases for the Care of Patients in the S.A.U.V (Vital Emergency Rooms) of the CHU de Caen
concordance between the lactate values on peripheral venous and arterial blood gases in all patients receiving an arterial sample on their arrival in the S.A.U.V.
- Trial name
- GDS (NCT05971615)
- Testing
- peripheral venous blood gases
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Interventional Imaging
Evaluation of Immersion in Virtual Reality in the Management of Anxiety, Then Pain, of Patients in Interventional Imaging.
Investigators propose to use static VR scenarios, adapted to the patient's preferences (sea, mountain, countryside…) to immerse them in an emotionally positive environment.
- Trial name
- IRVARI (NCT05966402)
- Testing
- Virtual Reality
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Pulmonary Ultrasound, Weaning Failure
Predictive Value of Chest Ultrasound Observation on Extubation Failure
The use of mechanical ventilation in intensive care concerns the majority of patients, most often to compensate for respiratory failure, but for other organic failures requiring therapeutic artificial coma.
- Conditions
- Pulmonary Ultrasound, Weaning Failure, Ultrasound, Lung Edema
- Trial name
- ECHOEXTUB (NCT05944588)
- Testing
- Pulmonary Ultrasound
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Memory Disorders
Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases
The Inserm NeuroPresage team has been using MRI for more than 20 years in the study of normal ageing and memory pathologies to further the understanding and the characterization of early diagnosis and the cerebral substrates of…
- Trial name
- IRMtests (NCT05929144)
- Testing
- MRI sequences testing
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Infections
Clozapine-associated Infection
perform a study in VigiBase® to assess if clozapine was associated with an over-reporting of infections and to characterize those infections.
- Trial name
- NCT05919550
- Testing
- search for a clozapine intake
- Where
- France
- Volunteers
- 26,815,616 people
- Sponsor
- University Hospital, Caen
Cancer
Arterial Hypertension Related to PARP Inhibitors (ArteRIB)
Although PARP inhibitors (PARPi) have proved effective in treating many cancers, few patients receiving PARPi may experience rare but serious (or not) adverse events such as hypertension whose data are scarce.
- Trial name
- NCT04774406
- Testing
- olaparib, rucaparib, niraparib, talazoparib, veliparib, pamiparib, fluzoparib
- Where
- France
- Volunteers
- 2,336 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers
MULTI-SYSTEM PHYSIOLOGIC RESPONSE TO VARYING LEVELS OF PARTIAL GRAVITY
Spaceflight induces detrimental changes in most organ systems with both acute changes and chronic adaptations. For example, acute fluid shifts associated with weightlessness (also called - improperly - microgravity) cause initial…
- Trial name
- GRAVIDOSE (NCT03963856)
- Testing
- parbolic flight
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Idiopathic Scoliosis
Influence of Social Deprivation and Remoteness on Quality of Life in Adolescent's Surgical Scoliosis
The incidence of idiopathic scoliosis is 3% or approximatively 300,000 new cases per year in France. It is estimated that between 0.1 and 0.3% of patients will eventually require surgical management, between 500 and 1000…
- Trial name
- NCT05575596
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Caen
Primary Immune Deficiency Disorder
Intensive Care Unit and Secondary and Primary Immune Deficiency
Primary immune deficiencies (PID) are characterized by a failure of the immune system that is not explained by any infectious, neoplastic, or iatrogenic cause.
- Trial name
- ICUSPID (NCT02888535)
- Testing
- Internal Medicine consultation
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Caen
Anesthesia Morbidity, Child, Only
Impact of Preoperative Fasting on Intraoperative Glycemic Homeostasis and Enhanced Recovery in Children
In 2018, the main societies of anesthesia (European Society Anaesthesiology, European Society Pediatric Anesthesia, and Association des Anesthésistes Réanimateurs Pédiatriques d'Expression Française) changed the current…
- Conditions
- Anesthesia Morbidity, Child, Only, Fasting Hypoglycemia
- Trial name
- GLYNEMCaen (NCT04826627)
- Testing
- glycemia
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Attention Deficit Disorder
Markers of Executive Attention Development in Preschoolers
This project aims to identify precursors of executive attention that can serve as early markers of ADD.
- Trial name
- MEDiATE (NCT04548245)
- Testing
- EEG
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Intubation; Difficult
Mallampati Classification vs Best Visible Mallampati for Prediction of Difficult Tracheal Intubation
Mallampati score (classification of the visibility of oropharyngeal structures) should be performed in the sitting position, head in the neutral position, mouth widely open, and tongue protrudes, without phonation.
- Trial name
- NCT02788253
- Where
- France
- Volunteers
- 3,244 people
- Sponsor
- University Hospital, Caen
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- PRESAGE (NCT05640141)
- Testing
- MRI evaluation, Actimetry & IMU, Gait evaluation
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Dyslexia, Adolescent
Usefulness of an Assistive Technology Training Program for Adolscents With Dyslexia
Specific Written Language Disorders (SWLD) are severe and lasting impairments in the development of written language that affect approximately 10% of the school-age population.Concerned patients don't have any intellectual…
- Trial name
- FormONC (NCT05636813)
- Testing
- Training
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Immuno-Deficiency
Pediatric Intensive Care Unit and Primary Immune Deficiency
To date, many studies have focused on the characteristics of PID in children, allowing to highlight an entry into the disease in the context of more or less severe infections in all pediatric departments.
- Trial name
- PICUPID (NCT05629247)
- Testing
- Systematic screening of immune deficiency
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Antidepressants Causing Adverse Effects in Therapeutic Use, Fall
Association Between Antidepressant Use and Falls in Older Adults: Analysis of the World Health Organization Global Database
The incidence of fall in older adults aged 65 and over is estimated at 30%, and 50% of the people aged 80 and over with at least one fall a year. Falls are associated with significant morbidity and mortality.
- Trial name
- NCT05628467
- Testing
- Antidepressive Agents
- Where
- France
- Volunteers
- 100,000 people
- Sponsor
- University Hospital, Caen
Motion Sickness
Motion Sickness Desensitization Using VR
Evaluation of a virtual reality desensitization protocol on subjects with severe motion sickness and study of the role of the emotional component on the effectiveness of the therapy.
- Trial name
- SENSORIEL1 (NCT05628220)
- Testing
- physiotherapy
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Stroke
Prospective Cohort Study : Evaluation of Prognosis Criteria for Walking Independently Recovery After Stroke.
Based on a 2017 US study that developed an algorithm for predicting independent walking recovery after stroke, we propose a prospective study to assess the validity and applicability of this algorithm in the majority of stroke…
- Trial name
- NCT05572892
- Testing
- FAC scale
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Caen
Type 2 Diabetes Mellitus
Switch From U-100 Insulin Analog to U-500 Regular Insulin in Pumps for Type 2 Diabetes
The aim of the study was to perform a 3-year retrospective analysis from a cohort of patients with type 2 diabetes that were treated by a pump device and were uncontrolled despite high U-100 insulin requirements.
- Trial name
- NCT04371497
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen