Clinical trials: sponsored by University Hospital, Caen
Extubation Failure
Ventilation Support for the PREvenTion of EXTubation Failure
Reintubation after failed extubation would be associated with increased mortality. Therefore, extubation failure remains a major concern in ICU.
- Trial name
- PRETEEXT (NCT05550259)
- Testing
- protocolized postextubation support
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Cancer
Atrial Fibrillation and Cancer: a Nationwide French Cohort Study
Atrial fibrillation (AF) is a common complication associated with cancer but the risk of AF according to the cancer localization and status as well as the risk of thromboembolisms, bleedings and mortality are poorly known.
- Conditions
- Atrial Fibrillation, Cancer, Thromboembolism, Bleeding
- Trial name
- NCT05563883
- Testing
- event occurence
- Where
- France
- Volunteers
- 5,000,000 people
- Sponsor
- University Hospital, Caen
Type 2 Diabetes Mellitus
Switch From U-100 Insulin Analog to U-500 Regular Insulin in Pumps for Type 2 Diabetes
The aim of the study was to perform a 3-year retrospective analysis from a cohort of patients with type 2 diabetes that were treated by a pump device and were uncontrolled despite high U-100 insulin requirements.
- Trial name
- NCT04371497
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen
Multiple Myeloma, Adapted Physical Activity
Benefits of Adapted Physical Activity for Chronic Osteoarticular Pain in Patients With Multiple Myeloma
Pain is one of the most frequent symptoms leading patients to consult a doctor, particularly in rheumatology and cancerology. When it becomes chronic, pain is the cause of a major emotional and physical invasion, with harmful…
- Conditions
- Multiple Myeloma, Adapted Physical Activity, Chronic Pain
- Trial name
- ALGOMYELOMOV (NCT05548686)
- Testing
- adapted physical activity
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Sports Injury
Trail Sciences Clecy: Markers of Performances
The Scientific Trail Protocol of Clécy - Suisse Normande (TCS) is exploratory study including several specific protocols, on a real event of 156 km on hilly terrain (6000 m of difference in level), allowing to evaluate the…
- Trial name
- NCT05538442
- Testing
- Physiological recordings
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Morals, Covid19
Medical Triage in a Time of Scarce Resources.
The XPHI-COVID-2 randomized study aims to investigate the moral choices in a context of scarce resources. The participants are asked to complete the questionnaire of the Oxford Utilitarianism Scale and are exposed to medical…
- Conditions
- Morals, Covid19, Ethics, Narrative
- Trial name
- XPHI-COVID-2 (NCT04982770)
- Testing
- Survey
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hypoxia
Effects of Dihydropyridine Calcium Channel Inhibitors on Respiratory Gas Exchanges in the Intensive Care Unit: a Pharmacovigilance Study in VigiBase® and a Comparison With Urapidil
Due to their effects on hypoxic pulmonary vasoconstriction (HPV), dihydropyridine calcium channel inhibitors (CCI) could lead to hypoxia in patients with a pulmonary shunt.
- Trial name
- NCT05537194
- Testing
- dihydropyridine calcium channel inhibitors use
- Where
- France
- Volunteers
- 32,000,000 people
- Sponsor
- University Hospital, Caen
Dizziness; Syndrome
Integrative Study of Vestibular Pathology
Exploratory posturological, neurosensory, cognitive, emotional, personality and general evaluations (quality of life). The investigators will characterize a sensory profile quantified by one or more scores from a multi-parameter…
- Trial name
- SENSORIEL2 (NCT05525728)
- Testing
- Neurosensory
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
Pharmacogenetics of Liver Toxicity in Patients With Multiple Sclerosis Treated With Fingolimod
To investigate whether polymorphic differences can be identified between Multiple Sclerosis patients developing elevated liver enzymes (defined as ALT, AST, GGT or bilirubinemia levels five above the upper normal limit on at…
- Trial name
- NCT05516303
- Testing
- Genetic polymorphism, Measurement of fingolimod and fingolimod-phosphate concentrations
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen
Type 2 Diabetes, Insulin Resistance
Effect of Neuromuscular Electrostimulation on Sympathetic Nerve Activity in Patients With Type 2 Diabetes (ELECTROSYMP2)
Physical activity (PA) is recommended for the treatment of subjects with type 2 diabetes to increase insulin sensitivity and improve metabolic control.
- Trial name
- ELECTROSYMP2 (NCT02171351)
- Testing
- effect of neuromuscular electrostimulation (NMES), effect of neuro electrostimulation (NES), effect of voluntary contractions (VC)
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Von Willebrand Disease, Type 2B
Impact of Von Willebrand Factor-platelet Aggregates in Patients With Type 2B Disease
The working hypothesis is that patients with Von Willebrand Disease-type 2B may have neurological symptoms due to the chronic formation of platelets/Von Willebrand Factor aggregates.
- Trial name
- Von2B (NCT05015244)
- Testing
- 3T (Tesla) Magnetic Resonance Imaging (MRI)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Caen
ELDRELY
Nutritional Status in Patients Over 65 Years of Age and Meal Presentation
The prevalence of undernutrition in hospitals is estimated between 30 and 40% and up to 50% in the elderly. The consequences of undernutrition are significant: complications, delayed healing, higher risk of infections, pressure…
- Trial name
- NUPOBA (NCT04696068)
- Testing
- Porcelain plates
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Music, Anesthetic, Induction
Evaluation of the Effect of Musical Listening on Hypnotic Savings During the Induction of General Anesthesia
Anesthetic induction requires the use of, among other things, hypnotic drugs that can lead to hemodynamic disorders, postoperative cognitive dysfunctions and delayed awakening.
- Trial name
- MUSINDUC (NCT03941847)
- Testing
- music
- Where
- France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Caen
Liver Cirrhosis
Evaluation of Accuvein in Cirrhotics Patients
The objective of this study is to evaluate the effectiveness of AccuVein AV400 to facilitate placement of peripheral intravenous catheters in cirrhotic adults by comparing the success rate of the first attempt to install a…
- Trial name
- CIRRVVUS (NCT03996135)
- Testing
- Cannulation with AccuVein AV400
- Where
- France
- Volunteers
- 280 people
- Sponsor
- University Hospital, Caen
Type 2 Diabetes, Physical Activity
Effect of Electrostimulation on Glucose Profile of Patients With Type 2 Diabetes
Prevalence of type 2 diabetes (T2D) is increasing worldwide. Lifestyle remains the cornerstone treatment for patients with T2D who are often overweight and sedentary.
- Trial name
- ELECTRODIAB2 (NCT02157480)
- Testing
- electrostimulation (with Compex® Compex2* (DJO, Vista, CA, USA)) 3 days per week ., electrostimulation (with Compex® Compex2* (DJO, Vista, CA, USA)) 5 days per week
- Where
- 5 sites in France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Caen
Neurodevelopmental Disorders, Premature Birth
Neural Correlates of Tactile Prediction
This project aims to measure repetition suppression and tactile prediction using high-resolution electroencephalography in preschoolers, in order to describe the responses as a function of age, gestational age of birth and the…
- Trial name
- DECODE (NCT04844853)
- Testing
- electroencephalography, Tactile stimulation, Attention Network task (computerized)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Non-metastatic Colorectal Cancer, Empathy
Role of Empathy in Curative Treatment Outcomes of Non-metastatic Colorectal Cancer.
The aim of project EMPACOL will be to investigate, while taking into consideration the clinical factors known and well described in the literature, among the non-clinical factors, in particular, patient-healthcare personnel (HCP)…
- Conditions
- Non-metastatic Colorectal Cancer, Empathy, Morbidity, Morality
- Trial name
- EMPACOL (NCT05447611)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Fall Patients
Effect of Playful Cognitive-motor Mobility Training on Balance, Gait and Cognition and on the Prevention of Falls in Seniors
Falls in the elderly are the cause of considerable morbidity and mortality and constitute a public health problem with more than 9000 deaths in France among the over 65s following an accidental fall.
- Trial name
- GATE (NCT05422495)
- Testing
- training with Cycléo device (COTTOS ®),, non intervention
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Daily Home Hemodialysis
Controlled Internal Convection in Low Flow Hemodialysis of Dialysate: Removal of Beta-2-microglobulin
Since 2013 daily home hemodialysis allows low volumes of convection. This study is a prospective cross-over trial testing the efficiency of internal convection on Beta2-microglobulin in daily home hemodialysis.
- Trial name
- CIMHBaDD (NCT05419271)
- Testing
- home hemodialysis session with 9L internal convection
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Caen
Vaccine Adverse Reaction
COVID-19 Vaccines Associated Malaise
COVID-19 vaccines induced malaise have recently been reported in the literature. Our study aims to identify risk factors associated with the onset of COVID-19 vaccines induced malaise and to assess if certain COVID-19 vaccines…
- Trial name
- NCT05234333
- Testing
- SARS-CoV-2 vaccine
- Where
- France
- Volunteers
- 1,534,706 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen