Clinical trials: sponsored by University Hospital, Caen
Mood Disorders
Comparison of Mood Disorders Screening Scales in Geriatric Oncology
The objective of this study is to evaluate the scales commonly used in geriatrics and oncology distress thermometer ( analogue scale rated from 0 to 1 for the emotional distress ) , the GDS15 (15 issues closed binary response…
- Trial name
- Thymog (NCT02799524)
- Testing
- comparison of screening scales
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Caen
Myocardial Infarction, Intracoronary Thrombus
Intracoronary Thrombus Assessed by OFDI After Successful Fibrinolysis And Its Impact On Myocardial Reperfusion
The pharmacoinvasive approach after thrombolysis is the standard treatment of myocardial infarction when deadlines are too long for primary angioplasty.
- Trial name
- AODIS (NCT02850315)
- Testing
- optimal coherence tomography
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Caen
Maximum Voluntary Contraction
Muscular Force Generation in Microgravity
The aim of this study is to evaluate the applicability of high-load resistance training as a countermeasure for long term space flights, the current project has two scientific goals.
- Trial name
- ForceGeneratio (NCT02850328)
- Testing
- examination of muscle function and MVC in weightlessness
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Social Cognition in Patients With Schizophrenia
Treating Social Cognition With Theta Burst Stimulation; a Pilot Sudy
The purpose of the study is to test a new treatment of social cognition deficits in patients with schizophrenia or schizoaffective disorder by transcranial magnetic stimulation (theta-burst).
- Trial name
- PilotTMS-COG (NCT02440867)
- Testing
- Active TBS
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Lower Limb Vascular Surgery - Femoral Artery Endarteriectomy
Prediction of Femoral Revascularization Quality Using the Somatic NIRS Signal
Despite effective femoral artery endarteriectomy, patients with occlusive arteritis may need complementary stenting of revascularization procedures within the 2 years after the primary surgery because of a poor blood supply in…
- Trial name
- TEA-NIRS (NCT02337920)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Caen
Cardiac Arrest
Compression Is Life In Cardiac Arrest - Quality Study (CILICA-QS)
Context: Chest compressions quality is known to be essential in cardiopulmonary resuscitation. Despite a known harmful effect of chest compressions interruptions, current guidelines still recommend provider switch every 2…
- Trial name
- CILICA-QS (NCT03140202)
- Testing
- CPRmeter (feedback device) with feedback, CPRmeter (feedback device) without feedback
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Stroke Volume Variation, Arterial Pressure
Comparison of Hemodynamic Effect of 2 Methods for Alveolar Recruitment Maneuver in Anesthetized Patients
During general anaesthesia, pulmonary atelectasis has been shown to occur in 85 to 90% of patient. Pulmonary atelectasis increases occurrence of postoperative pulmonary complication including pneumoniae.
- Trial name
- Hemorecrut (NCT03215329)
- Testing
- abdominal or vascular surgery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Preoxygenation, Non Invasive Ventilation
Preoxygenation Method With a Calibrated Leak
During preoxygenation, imperfect seal between the face mask and patient's face can induce an inward air leak decreasing its effectiveness. We assume that noninvasive ventilation could cancel the effect of the leak.
- Trial name
- NCT03087825
- Testing
- preoxygenation without inward leak, preoxygenation with inward leak
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Sedation
Impact of a Nurse Implemented Sedation and Analgesia Algorithm in Surgical Intensive Care Unit
To show that the nurse implementation of a sedation and analgesia algorithm is beneficial to the patient in terms of sedative drugs reduction and thus overall decrease in duration of mechanical ventilation and the morbidity and…
- Trial name
- ALGOSEDA (NCT03186521)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Antipsychotics in Palliative Care
Use of Antipsychotics in Palliative Care (NEUROPAL)
There are not lots of recommendations for the use of antipsychotics in palliative care. The National Agency for Accreditation and Evaluation in Health (ANAES) and the French Society for Accompaniment and Palliative Care, in 2002…
- Trial name
- NEUROPAL (NCT03155685)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Other Functional Disturbances Following Cardiac Surgery
Continuous MONItoring of Blood LActate and Glucose Levels Using a New Central Veinous Microdialysis Catheter Device
Continuous lactate and glucose blood levels
- Trial name
- MONILAG (NCT02296593)
- Testing
- comparison of blood lactate and glucose levels
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Chronic Graft Versus Host Disease
Evaluation of the Diagnostic Value of PET (18F-FDG) in Chronic Graft Versus Host Disease (cGVH)
Allogeneic stem cell transplantation was developed to cure many patients with hematological malignancies. It results in the development of graft versus host disease (GVHD) in 30-70% of cases.
- Trial name
- TEP-GVH (NCT02352064)
- Testing
- PET (18-FDG)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Caen
HIV
Adherence to Dolutegravir and Outcome
The main assumption is that the dolutegravir can get virologic suppression to suboptimal adherence levels (between 80 and 95%, and after treatment interruptions) where other molecules are not capable, due to their…
- Trial name
- DOLUTECAPS (NCT02878642)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Caen
Catheter Complications, Thrombosis
Comparison Between Sutureless Devices for PICC and a New System KT FIX PLUS
PICC (Peripherally Inserted Central Catheter) are commun used. Just one paper report morbidity with suture as fixation system for PICC (dislodgement, infection) In the guidelines it's recommended to use sutureless device.
- Conditions
- Catheter Complications, Thrombosis, Displacement of Infusion Catheter, Quality of Life
- Trial name
- KTFIXPICC (NCT02805335)
- Testing
- KTFIX PLUS
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Heart Failure
Three-dimensional Assessment of Intraventricular Dyssynchrony Using Fast Dobutamine Gated SPECT
The prognosis of patients with heart failure has improved due to recent breakthrough in medical treatment and cardiac resynchronization devices.
- Trial name
- FAST DOGS (NCT02510677)
- Testing
- myocardial perfusion scintigraphy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Caen
Healthy Children, Preterm Birth
Executive Training and Brain in Children
The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and…
- Trial name
- APEX (NCT02989116)
- Testing
- Inhibition training, Working memory training, Mindfulness training
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Gestational Diabetes
Assessment of Patient Satisfaction Program "Gestational Diabetes"
This study seeks to evaluate patient satisfaction within the patient therapeutic education program "gestational diabetes" (multidisciplinary and multi-professional program) to see if they deem effective to limit the impact of…
- Trial name
- SATISFYDG (NCT02945540)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Caen
Hemophilia A
Evaluation of Clot Stability Induced by Solulin: Evaluation of New Solulin Mutants Lacking Protein C Activation Capacity
Hemophilia A is a rare X chromosome-linked recessive bleeding disorder that concerns one individual in 5000. In its severe form, hemophilia A is a life-threatening, crippling hemorrhagic disease.
- Trial name
- SOLUCLOT (NCT02911233)
- Testing
- Thromboelastograpgy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Caen
Head and Neck Cancer
Therapeutic Education Program for Laryngectomised Patients and Their Close Relations
The therapeutic education of patients and their close relations is, as yet, poorly developed in France in the field of oncology, in particular for cancers of the upper aerodigestive tract.
- Trial name
- PETAL (NCT02903875)
- Testing
- Patient therapeutic education (PTE) programme
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Caen
Stroke
Interest of Thromboelastography (ROTEM) as a Biomarker of Revascularisation in Stroke
Revascularisation using recombinant tPA is the reference treatment of stroke. However, the efficacy of fibrinolysis is about 50%.
- Trial name
- ROTEMPredict (NCT02902393)
- Testing
- Thromboelastography
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Caen