Clinical trials: sponsored by University Hospital, Caen
Healthy Volunteers
Cardiovascular Response to Orthostatic Fractional Gravity
There are no equivalent experiment setups to create comparable changes of gravitation such as during parabolic flights. To determine the initial orthostatic responses of the cardiovascular system under the gravitational…
- Trial name
- ORB (NCT02508818)
- Testing
- Parabolic flight, Cardiovascular measurements
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Influence of Gravity on the Size-mass Illusion
Parabolic flight is the only ground-based condition in which free-fall (0G) can be created long enough for safely testing changes in human perception and behavior.
- Trial name
- Massper (NCT02507453)
- Testing
- parabolic flight, mass/weight perception estimation, ESA short-arm human centrifuge (SAHC)
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Obstetric Labor
Evaluation of the Impact of an Outpatient Obstetric Epidurals During Labor
Mobilization, ambulation, during obstetrical work attitudes are naturally adopted by women since ancient times in many countries. The advent of the epidural in the 60s revolutionized the management of pain during childbirth.
- Trial name
- PERIAMBU (NCT02507739)
- Testing
- no possibility to walk during labor, possibility to walk during labor
- Volunteers
- 320 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers
E-NOSE for Breath Gas Analysis Under Microgravity Conditions
The main goal of the study is demonstrate that e-Nose system function is not altered in weightlessness and more specifically that gas concentration measurements are the same in weightlessness and normal gravity.
- Trial name
- E-NOSE (NCT02507622)
- Testing
- measurement of the concentration of C02, CO and NH4, 3 exhaled gas with E-Nose system, Parabolic flight
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Chronic Pain
Observational Study of the Analgesic Effect of Treatment With rTMS in Patients With Chronic Neuropathic Pain
For ten years, rTMS, repetitive transcranial magnetic stimulation of the motor cortex, has found its place in the treatment of drug-resistant neuropathic pain.
- Trial name
- rTMSDOULNEURO (NCT02506699)
- Testing
- analgesic effect of rTMS
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Newborn Cleft Lip and Slot Carrier
Biochemical and Histological Comparison of Nasal and Auricular Cartilage in the Fetus and Newborn With Cleft Lip Carrier
We seek to compare biochemically and histologically the nasal cartilage and ear in the newborn cleft lip and slot carrier in order to improve the quality of care and patient comfort after surgery of cheilorhinoplasty which is the…
- Trial name
- CARTOON (NCT02505360)
- Testing
- Measurements of concentration of hyaluronic acid as well as in type 1 collagen and 3
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Hypovolemia
Correlation Between ΔPP/HR and ΔSV During Fluid Challenge.
In high perioperative risk patients, guidelines suggest intraoperative haemodynamic optimization by measurement of stroke volume (SV) to guide fluid resucitation.This strategy requires an invasive monitoring and learning.
- Trial name
- ΔPP/HRvsΔSV (NCT02439242)
- Testing
- fluid challenge of saline
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Preterm Birth, Parenting
Impact of an Intervention Program on Parenting Stress After Preterm Birth
The aim of this study was to assess the impact of an early psychological intervention, Triadic parent-infant Relationship Therapy (TRT), on parenting stress, parental mental health, and preterm infant development in the motor…
- Conditions
- Preterm Birth, Parenting, Mental Health Wellness 1, Parent-Child Relation
- Trial name
- IDEX (NCT02394444)
- Testing
- Triadic parent-infant Relationship Therapy (TRT)
- Volunteers
- 89 people
- Sponsor
- University Hospital, Caen
Interpersonal Relations, Schizophrenia
Exploration of Neural Bases in Social Cognition
An impairment in social cognition in schizophrenia could account for the severe professional and social difficulties among patients. Social cognition is the way the social world is understood, perceived and interpreted.
- Conditions
- Interpersonal Relations, Schizophrenia, Magnetic Resonance Imaging, Functional
- Trial name
- IRM-COG (NCT02110017)
- Testing
- fMRI social cognition task
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Neuromuscular Monitoring
Comparison of Two Neuromuscular Monitors
Different neuromuscular monitors may be available in the same care structure. Two different monitors are available in the investigators' institution in the operative room and the recovery room.
- Trial name
- NMT-STIMPOD (NCT02350062)
- Volunteers
- 17 people
- Sponsor
- University Hospital, Caen
Diastolic Dysfunction and Cardiac Stiffness
Cardiac Elastography Measurement : an Intraoperative Cardiac Surgery Study
Since 20 years, the techniques of direct measurement of cardiac stiffness in the diagnosis of myocardial diseases do not exist. We propose a human study evaluating the direct measurement of cardiac ultrasound stiffness by…
- Trial name
- REA-FO (NCT02051920)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Cardiac Arrest
Compression Is Life In Cardiac Arrest - Fatigue Study
Context: Chest compressions represent an important physical effort leading to fatigue and cardiopulmonary resuscitation quality degradation.
- Trial name
- CILICA-FS (NCT02322359)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Kidney Failure, Acute, Critical Illness
Comparison of Femoral Versus Jugular Routes for Temporary Hemodialysis in Seriously Ill Patients
The purpose of this study is to determine whether a jugular route leads to a lower rate of complications as compared with a femoral route for catheterization in patients admitted in several intensive care units in France who…
- Trial name
- CATHEDIA (NCT00277888)
- Testing
- Femoral route for hemodialysis, Jugular route for hemodialysis
- Where
- 10 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Caen
Autistic Disorder
Associative Memory in Adults With an Autism Spectrum Disorder
The objective of this multidisciplinary project is to explore the deficit of associative memory in ASD (Autistic Spectrum Disorder) that could result from abnormal brain connectivity.
- Trial name
- MEM-T2A (NCT02279680)
- Testing
- Electroencephalography, Neuropsychological assesments
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hypotension
Influence of Preload Dependence on the Effect of Phenylephrine on Cardiac Output
The perioperative hemodynamic management aims to ensure organ perfusion pressure and an oxygen arterial transport adapted to oxygen consumption.
- Trial name
- NCT01730820
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Hypovolemia, Impaired Oxygen Delivery
Observational Study of Oxygen Delivery During a Fractional Fluid Expansion
Fluid expansion during cardiocirculatory insufficiency was helped by cardiac output monitoring. However, the goal of fluid expansion was to increase the oxygen delivery, which consider cardiac output, but also Haemoglobin which…
- Conditions
- Hypovolemia, Impaired Oxygen Delivery, Cardiac Output, Low
- Trial name
- OR (NCT01826253)
- Testing
- hydroxyethylstarch 130/0.4
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Acute Respiratory Failure
NAVASET: Nava Level Titration Using Comfort Scales
Determining the optimal Neurally Adjusted Ventilatory Assist (NAVA) level remains challenging, and several methods have been suggested. However none of them seems easily utilisable.
- Trial name
- NCT02133443
- Testing
- PSV - pressure support ventilation, Neurally Adjusted Ventilatory Assist
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Heart Disease
Coronary Flow Reserve Evaluation in PET and in MRI Scanner in Heart Transplanted Patients : Comparison With Multi-detectors Scanner
Heart transplantation is the ultimate therapeutic option in patients with end-stage heart failure. Since advances in the treatment of acute rejection has increased early transplant survival, cardiac allograft vasculopathy (CAV)…
- Trial name
- RECOPE (NCT01231815)
- Testing
- 15O-H2O PET -, MRI
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Blood Coagulation Disorders, Blood Coagulation Disorder With Prolonged Bleeding Time
Accuracy of a Portable International Normalized Ratio Monitor in Elderly Patients
Oral anticoagulants vitamin K antagonists (VKA) have been used for many years in the treatment of thromboembolic disorders, which are among the most costly diseases in terms of public health resources.
- Conditions
- Blood Coagulation Disorders, Blood Coagulation Disorder With Prolonged Bleeding Time, Blood Coagulation Disorder With Prolonged Coagulation Time
- Trial name
- AGINR (NCT01930916)
- Testing
- INR capillary measurement with INRatio 2 device, antiphospholipid antibodies and lupus anticoagulant
- Where
- 4 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Pulmonary Arterial Hypertension
Resynchronisation Therapy of Right Ventricle in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension is a disease characterised by pathological changes in the pulmonary arteries leading to a progressive increase in pulmonary vascular resistance and pulmonary artery pressure.
- Trial name
- RETRIEVE (NCT01905189)
- Testing
- Resynchronization therapy of right ventricle
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen