Clinical trials: sponsored by University Hospital, Geneva
Acute Kidney Injury
Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy
Critically ill patients with acute kidney injury (AKI) are at high risk of bleeding on account of coagulopathy, platelet dysfunction, frequent liver dysfunction and invasive procedures.In patients at high risk of bleeding…
- Trial name
- NCT01269112
- Testing
- citrate regional anticoagulation
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University Hospital, Geneva
Pain, Postoperative
Addition of Popliteal Plexus Block to Continuous Femoral Nerve Block for Total Knee Arthroplasty
The popliteal plexus block has been described as an alternative analgesic postoperative pain treatment for total knee arthroplasty.
- Trial name
- NCT04048889
- Testing
- Ropivacaine 0.5% Injectable Solution
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Critical Illness
The ICALIC International Multicentric Study
This study will evaluate the ease of use of the new calorimeter (Q-NRG (COSMED, Italy)) in intensive care unit (ICU) patients compared to currently used calorimeters (i.e.
- Trial name
- ICALIC (NCT02796430)
- Testing
- Time needed to start indirect calorimetry measurement, Indirect calorimetry measurement
- Where
- 7 sites in Austria, Belgium and 4 more
- Volunteers
- 272 people
- Sponsor
- University Hospital, Geneva
Stages III Skin Melanoma, Stages II Skin Melanoma
Efficacy of Propranolol Treatment to Prevent Melanoma Progression
Melanoma's incidence is increasing worldwide. The efforts made in melanoma screening led to an earlier detection of the primary tumour and a better prognosis, but melanoma remains an aggressive cancer when it comes to its…
- Conditions
- Stages III Skin Melanoma, Stages II Skin Melanoma, Stage IB Skin Melanoma
- Trial name
- NCT01988831
- Testing
- Propranolol hydrochloride
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- University Hospital, Geneva
Insulin Resistance
Extrahepatic Insulin Resistance in Chronic Hepatitis C
In this pilot study, the investigators plan to treat patients with chronic hepatitis C due to HCV genotype 3 infection using an interferon-free regimen consisting in the administration of ribavirin and sofosbuvir/ledipasvir - a…
- Trial name
- NCT02760355
- Testing
- Ledipasvir 90 mg/Sofosbuvir 400 mg, Ribavirin
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- University Hospital, Geneva
Abdominal Sepsis, Peritonitis
Impact of Early Peri-operative Use of Polymyxin-B Hemoperfusion in Septic Patients Undergoing Emergent Abdominal Surgery
Septic shock of intra-abdominal origin is likely due to Gram-negative bacteria or mixed pathogens and associated with high levels of endotoxin.
- Conditions
- Abdominal Sepsis, Peritonitis, Colon Perforation
- Trial name
- NCT01646229
- Testing
- Polymyxin-B hemoperfusion, Control
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University Hospital, Geneva
Sciatica
Adalimumab in Severe and Acute Sciatica
The purpose of this study is to determine whether adalimumab (a TNF-alpha inhibitor) is effective in the treatment of severe and acute sciatica.
- Trial name
- ASAS (NCT00470509)
- Testing
- Adalimumab
- Where
- Switzerland
- Volunteers
- 61 people
- Sponsor
- University Hospital, Geneva
Hypertension, Essential Hypertension
Resistant Arterial Hypertension Cohort Study
The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used…
- Conditions
- Hypertension, Essential Hypertension, Resistant Hypertension
- Trial name
- RAHyCo (NCT01083017)
- Testing
- chlorthalidone, motivational intervention for non-compliant individuals, standardized anti-hypertensive treatment
- Where
- 3 sites in Switzerland
- Volunteers
- 74 people
- Sponsor
- University Hospital, Geneva
Parkinson Disease, Tremor, Essential
Effectiveness and Reliability of Hypnosis in Stereotaxy
In certain neurosurgical procedures, the use of a stereotaxic frame is required. It is then possible to set a precise target (depending of the type of the surgery) to be reached by the surgeon.
- Conditions
- Parkinson Disease, Tremor, Essential, Dystonia, Primary
- Trial name
- ERST (NCT03074422)
- Testing
- Hypnosis
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Geneva
Nut Allergy in Children
Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction of Other Tree Nuts?
The aim of this study is to identify, based on standardized food provocation tests, which nuts allergic patients need a selective, or a complete dietary eviction of all kind of nuts (nuts being defined as peanut, all tree nuts…
- Trial name
- ProNut (NCT01744990)
- Testing
- Oral food challenges to multiple nuts
- Where
- 4 sites in Spain, Switzerland and 1 more
- Volunteers
- 130 people
- Sponsor
- University Hospital, Geneva
Deep Vein Thrombosis, D-dimer
Age-adjusted D-dimer Cutoff Levels to Rule Out Deep Vein Thrombosis: a Prospective Outcome Study
Prospective validation of an age-adjusted D-dimer cut-off to rule out deep vein thrombosis (DVT)
- Trial name
- ADJUST-DVT (NCT02384135)
- Testing
- Three-month thromboembolic risk in patient with D-dimer levels between the usual cut-off and the age-adjusted cut-off
- Where
- 15 sites in Canada, France and 1 more
- Volunteers
- 3,300 people
- Sponsor
- University Hospital, Geneva
Arthritis, Septic
Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis
The optimal duration of systemic antibiotic administration for native joint septic arthritis is unknown. The investigators perform a randomized study allowing up to 3 surgical lavages and allocating patients into a two-week's and…
- Trial name
- NCT03615781
- Testing
- Two week's arm - surgery, Four week's arm - surgery, Two week's arm - drugs
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University Hospital, Geneva
Implant Infection
Short vs. Long Antibiotic Treatment of Implant-free Osteoarticular Infections
The investigators tested the working hypothesis if 4 weeks of systemic antibiotic treatment in implant-related orthopaedic infections is non-inferior to 6 weeks after complete removal of the infected implant. Randomization 1:1.
- Trial name
- NCT03602209
- Testing
- Removal of infected implant, Antibiotic durations
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Geneva
Paracetamol Toxicity, Hepatotoxicity
APAP Hepatotoxicity After Therapeutic Doses
Paracetamol (acetaminophen, APAP) is the most commonly used antipyretic and painkiller worldwide, but also the leading cause of acute liver failure (ALF) in developed countries after supra-therapeutic doses (half overdoses being…
- Conditions
- Paracetamol Toxicity, Hepatotoxicity, Malnutrition
- Trial name
- NCT03602274
- Testing
- Hepatic function monitoring, Nutritional status assesment, Biomarker research sampling
- Where
- Switzerland
- Volunteers
- 96 people
- Sponsor
- University Hospital, Geneva
Cancer of the Uterine Cervix
Feasibility and Acceptability of Offering Self-sampling to Non-attendees in Primary Care
The purpose of this study is to determine whether human-papillomavirus (HPV) self-sampling can be used as a primary screening test for unscreened women.
- Trial name
- DEPIST (NCT02698423)
- Testing
- Cobas HPV DNA Test, Papanicolau test
- Volunteers
- 667 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Gastrointestinal Hemorrhage
Glasgow-Blatschford Score Validation in Digestive Hemorrhage
The purpose of this study is to validate the Glasgow-Blatchford score for the stratification of patients with upper gastro-intestinal hemorrhage. This score is easy to calculate.
- Trial name
- NCT01029626
- Testing
- Endoscopy
- Where
- Switzerland
- Volunteers
- 208 people
- Sponsor
- University Hospital, Geneva
Pulmonary Embolism, Deep Vein Thrombosis
Ruling Out Pulmonary Embolism During Pregnancy:a Multicenter Outcome Study
Venous thromboembolism (VTE) remains a major cause of maternal morbidity and mortality in developed countries. Objective diagnosis of pulmonary embolism (PE) and/or deep vein thrombosis (DVT) in pregnancy is crucial.
- Trial name
- NCT00771303
- Testing
- Pregnant patients with suspected PE will undergo a strategy based on clinical probability assessment, D-dimer, lower limb vein ultrasonography and MSCT.
- Where
- 9 sites in France, Switzerland
- Volunteers
- 402 people
- Sponsor
- University Hospital, Geneva
Distal (Calf) Deep-vein Thrombosis
Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT)
CACTUS-PTS is a randomized, placebo-controlled, double-blind study which aims primarily to determine the effectiveness of a 6 week course of therapeutic-dose LMWH (nadroparine) injections vs.
- Trial name
- CACTUS-PTS (NCT00421538)
- Testing
- nadroparine calcium
- Where
- 7 sites in Canada, France and 1 more
- Volunteers
- 260 people
- Sponsor
- University Hospital, Geneva
Renal Alteration
Post-preeclampsia Renal Project: Study of Nephroprotection in Women Having Suffered Preeclampsia
The purpose of the Post-preeclampsia Renal Project is to investigate the renal function of preeclamptic women after delivery, and to determine whether the anti-hypertensive drug named benazepril efficiently improves the…
- Trial name
- RPPEC (NCT01095939)
- Testing
- Benazepril hydrochloride
- Where
- 2 sites in Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Geneva
HPV - Anogenital Human Papilloma Virus Infection
Prevalence of HPV Infection Using Self-sampling
Background: Currently prevalence of HPV infections for high risk strains among young women in Switzerland is unknown. In addition, since 2008 a vaccination program to prevent these infections has been implemented in a number of…
- Trial name
- NCT03474211
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva