Clinical trials: sponsored by University Hospital, Geneva
Chronic Subdural Hematomas, Cerebral Compression Due to Injury
Middle Meningeal Artery Embolization for Chronic Subdural Hematomas (STORMM)
Chronic Subdural Hematomas (cSHD) are common, and due to cerebral compression, often result in neurological impairment and reduced consciousness. Surgery is typically performed once neurological symptoms develop.
- Trial name
- STORMM (NCT06163547)
- Testing
- MMA embolization
- Where
- 2 sites in Switzerland
- Volunteers
- 180 people
- Sponsor
- University Hospital, Geneva
Nightmares, REM-Sleep Type, PTSD
Mental Imagery and Targeted Memory Reactivation in PTSD
With this protocol, investigators examine whether targeted memory reactivation (TMR), a technique used to strengthen memories, can accelerate remission of traumatic nightmares and post-traumatic stress disorder (PTSD)…
- Trial name
- NCT05933109
- Testing
- Imagery Rehearsal Therapy and Targeted memory reactivation during REM sleep, Imagery Rehearsal Therapy
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Geneva
Insomnia Disorder
Mental Imagery and Targeted Memory Reactivation in Insomnia
In this clinical trial, the investigators test whether mental Imagery Rescripting (IR), a technique where the individual is instructed to transform a negative memory or image into a positive one, and olfactory Targeted Memory…
- Trial name
- NCT06335784
- Testing
- Imagery Rescripting (IR), Imagery Rescripting (IR) and Targeted Memory Reactivation (TMR) during sleep, Sleep Hygiene
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Geneva
Rehabilitation Exercise, Oncologic Diseases
Home-Based Physiotherapy in Oncology
The goal of this clinical trial is to assess the feasibility, acceptability, and safety of a supervised home-based physiotherapy programme for adult oncology patients.
- Trial name
- NCT07440433
- Testing
- Home-based cycling + resistance training with physiotherapist supervision
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University Hospital, Geneva
PARKINSON DISEASE (Disorder)
Neural Correlates of Motor and Psychiatric Fluctuations in Parkinson's Disease
This study explores the electrophysiological mechanisms underlying motor and non-motor fluctuations (NMF) in Parkinson's disease (PD), focusing on cortical and subthalamic dynamics during acute dopaminergic stimulation.
- Trial name
- Transition STN (NCT07404241)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Pneumonia, Elderly Infection
CT Scan Compared to CXR and LUS in Pneumonia in the Elderly
Introduction: Pneumonia is a leading cause of mortality and a common indication for antibiotic in elderly patients. However, its diagnosis is often inaccurate.
- Trial name
- OCTOPLUS (NCT04978116)
- Testing
- Chest X-Ray (CXR), Low-dose CT scan (LDCT), Lung ultrasonography (LUS)
- Where
- 3 sites in Switzerland
- Volunteers
- 473 people
- Sponsor
- University Hospital, Geneva
Menopause, Obesity and Overweight
Time-Restricted Eating in Menopause and HOrmone-sensitive Breast Cancers (TREMHO)
This study is aimed at women currently going through menopause, either as part of the natural process (physiological menopause), or following hormonal treatment for breast cancer.
- Trial name
- TREMHO (NCT06855784)
- Testing
- Time-Restricted Eating 16h/8h, Active Control
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- University Hospital, Geneva
Cervical Cancer Screening, HPV Infections
Cervical Cancer Screening of Postmenopausal Women in Low- and Middle-income Countries Using HPV Self-sampling and Triage by Genotyping and Cytology
Cervical cancer remains a major cause of mortality in low- and middle-income countries, especially among women aged 50 years and older who are often under-screened.
- Conditions
- Cervical Cancer Screening, HPV Infections, Cervical Intraepithelial Neoplasia
- Trial name
- NCT07244315
- Testing
- Vaginal specimens for HPV test will be collected by participants themselves using flocked swabs after explanations by co-investigators.
- Where
- Cameroon
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Intracranial Aneurysm
@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms
The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA).
- Trial name
- @neurIST (NCT05526352)
- Where
- 22 sites in United States, Canada and 9 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Chronic Obstructive Pulmonary Disease (COPD), Heart Failure
Breathlessness Patterns in Patients With Cancer, COPD and Heart Failure: an fMRI Feasibility Study
Dyspnea that persists despite optimal pathophysiological treatment is defined as persistent dyspnea. Currently all brain functional magnetic resonance imaging (fMRI) studies conducted to evaluate breathlessness have done so using…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Heart Failure, Cancer, Volunteers
- Trial name
- BREACH-fMRI (NCT07319039)
- Testing
- Cerebral fMRI, Immersive virtual reality
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Contraception, Menstrual Management
Improving Shared Decision-Making in Menstrual Management and Contraception for Adolescents and Young Adults
Decision aids are educational tools designed to help people participate in decision-making about health care choices, by providing evidence-based information, promoting patient-centered care, and supporting patient autonomy and…
- Trial name
- NCT07320651
- Testing
- Encounter decision aid, Standard counseling
- Where
- Switzerland
- Volunteers
- 252 people
- Sponsor
- University Hospital, Geneva
Dementia, Alzheimer Disease
Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment
The objective of the study is to investigate the clinical validity of tau-PET with [18F]RO948 vs. amyloid-PET in patients with Mild Cognitive Impairment (MCI) or mild dementia
- Trial name
- IDV of tau-PET (NCT06618872)
- Testing
- PET/CT with RO958 (experimental)
- Where
- 2 sites in Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Geneva
Major Depressive Disorder (MDD), Anxiety Disorders
Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment
This retrospective observational study examines the effects of psychedelic-assisted psychotherapy (PAP) with lysergic acid diethylamide (LSD) or psilocybin in patients with treatment-resistant depressive, anxiety, or addictive…
- Conditions
- Major Depressive Disorder (MDD), Anxiety Disorders, Substance Use Disorder (SUD), PTSD - Post Traumatic Stress Disorder
- Trial name
- NCT07164287
- Testing
- Lysergic Acid Diethylamide (LSD) or psilocybin
- Where
- Switzerland
- Volunteers
- 376 people
- Sponsor
- University Hospital, Geneva
Tracheal Intubation
Assessment of Provider Position for Prehospital Tracheal Intubation
Endotracheal intubation may be needed in critically ill patients in the prehospital setting, where difficult conditions may be encountered.
- Trial name
- NCT07165314
- Testing
- Free positioning, Sitting cross-legged ("Lotus" position)
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Communication, Anxiety
Assessing the Impact of Therapeutic Communication on Patients' Anxiety During Elective Cesarean Sections
Background: Anxiety is highly prevalent before elective caesarean sections and can have a negative impact on anesthetic outcomes, postoperative pain and maternal mental health.
- Trial name
- CESARCOM (NCT07137377)
- Testing
- On line teaching CESARCOM teaching programe (immersive podcasts, digital flashcards)
- Where
- Switzerland
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Biliary Atresia, Kasai Portoenterostomy Status, Cholangitis
Cholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Cholangitis Post Kasai in Biliary Atresia)
Biliary atresia is a rare liver disease affecting newborns. In those babies bile ducts are blocked, and bile cannot flow from the liver to the intestines.
- Trial name
- TRACK-BA (NCT07129655)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Geneva
Keratoconus
The K-Map Study, Global Prevalence of KC
Keratoconus is a ocular disease classified under ectatic diseases which often results in bilateral and asymmetrical corneal distortion. It usually affects patients at young age and can cause severe visual loss.
- Trial name
- NCT03115710
- Testing
- Rotating Scheimpflug camera (Pentacam HR)
- Where
- 12 sites in United States, China and 10 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Pneumococcal Infections, Respiratory Syncytial Virus (RSV) Infection
In-depth Analysis of the Immune Responses in the Upper Respiratory Tract in Older Adults Infected or Colonized With Streptococcus Pneumoniae (Spn)
The NoseSpn-Elderly study aims at characterizing the immune response in the upper respiratory tract in adults aged 60 and over diagnosed with a pneumonia due to a Streptococcus pneumoniae (Spn) infection.
- Conditions
- Pneumococcal Infections, Respiratory Syncytial Virus (RSV) Infection, Influenza Infection
- Trial name
- NoseSpnElderly (NCT06998251)
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Influenza Infection
In-depth Analysis of the Immune Responses in the Upper Respiratory Tract of Influenza-infected Children
The NoseFlu-Kids project aims at characterizing the immune response in the upper respiratory tract in children aged 2 to 5 with a laboratory-confirmed influenza infection.
- Trial name
- NoseFlu-Kids (NCT06998264)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Geneva
Substance Use Disorders
Assertive Community Treatment for Patients Suffering From Substance Use Disorders
According to the World Health Organization the population suffering from addiction problems is increasing. This population is characterized by multiple needs at the medico-psychosocial level.
- Trial name
- NCT03623178
- Testing
- Assertive Community Treatment
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University Hospital, Geneva