Clinical trials: sponsored by University Hospital, Geneva
Treatment Adherence and Compliance, Psychiatric Disorder
The Use of Humor With Young Adults in Psychiatric Care
Clinical study in psychiatry in young adult patients between 18 and 25 years old. The aim of the study is to evaluate the therapeutic impact of the clinical use of humor through 6 group sessions (group of 5 to 10 patients), at…
- Trial name
- NCT04778163
- Testing
- Clinical use of humor
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University Hospital, Geneva
Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension
COVID-19 Pneumonia: Pulmonary Physiology, Health-related Quality of Life and Benefit of a Rehabilitation Program
The pathophysiological processes involved in COVID-19 pneumonia are not fully understood. Specific alterations of the airways, lung parenchyma and pulmonary vascular tree could explain a severe ventilation/perfusion heterogeneity…
- Conditions
- Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension, Myopathy, Restrictive Lung Disease
- Trial name
- COVISQAR (NCT04881214)
- Testing
- Pulmonary rehabilitation
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Informed Consent
One-time Informed Consent for Research in Prison
Ethical research on detained persons remains limited, including research on informed consent. This study aimed to fill in this research gap and compared audio-visual and paper-based materials for a one-time general informed…
- Trial name
- NCT05505058
- Testing
- Audio-visual material
- Where
- Switzerland
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Coronary Artery Disease
BIOSOLVE-IV Magmaris Swiss Satellite Registry
BIOSOLVE-IV Magmaris Swiss Satellite Registry is a prospective, single-arm, multicenter, nationwide open label registry. It is planned to enroll 200 subjects in up to 12 participating sites in Switzerland.
- Trial name
- NCT04025788
- Testing
- Magmaris Resorbable Magnesium Scaffold (RMS)
- Where
- 6 sites in Switzerland
- Volunteers
- 10 people
- Sponsor
- University Hospital, Geneva
Myocardial Stunning, Transesophageal Echocardiography
Rate of Left Ventricular Systolic Function's Recuperation After Cardiac Surgery With Extracorporeal Circulation.
The rational of the study is the description of the evolution of systolic cardiac function post-stunning, evaluated by transesophageal minimally invasive echocardiography (hTEE).
- Conditions
- Myocardial Stunning, Transesophageal Echocardiography, Circulation, Extracorporeal
- Trial name
- Imacor-1 (NCT02770183)
- Testing
- Imacor
- Sponsor
- University Hospital, Geneva
SARS-CoV-2 Viral Kinetics and Host Immune Responses
Understanding COVID-19
This single-center prospective observational study will examine immune responses to to SARS-CoV-2 and how they correlate with its virological characteristics and clinical manifestations in infected patients.
- Trial name
- NCT04329546
- Testing
- NA (no intervention)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Hospital, Geneva
COVID-19
Impact of COVID-19 Outbreak on Non-COVID-19 Patients
The Geneva Canton organized the health crisis of the COVID-19 epidemic around the care of COVID patients at the University Hospital (HUG), by moving the care of non-COVID patients to private hospitals of the canton.
- Trial name
- NoCOVImpact (NCT04537559)
- Where
- Switzerland
- Volunteers
- 240,000 people
- Sponsor
- University Hospital, Geneva
Social Anxiety Disorder, Sleep
Targeted Memory Reactivation During REM Sleep in Patients With Social Anxiety Disorder
With this study, the investigators aim to use sleep and dreaming in order to enhance exposure therapy for social anxiety disorder (SAD), by pairing the positive feedback phase of exposure (public talk) to an auditory stimulus…
- Trial name
- NCT05261659
- Testing
- Exposure Therapy and Targeted memory reactivation during REM sleep, Exposure Therapy
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University Hospital, Geneva
Myocardial Injury, Myocardial Ischemia
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
Perioperative myocardial injury (PMI) after non-cardiac surgery (NCS), i.e. the elevation of postoperative troponin, occurs in nearly 20% of patients older than 45 years undergoing NCS and is independently and strongly associated…
- Trial name
- PROTECTIN (NCT04436016)
- Testing
- Ivabradine
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- University Hospital, Geneva
Nightmares, REM-Sleep Type
Combined Treatment of Nightmares With Targeted Memory Reactivation and Imagery Rehearsal Therapy
With this protocol, investigators examine whether targeted memory reactivation (TMR), a technique used to strengthen memories, can accelerate remission of nightmare disorder.
- Trial name
- NCT05237778
- Testing
- Imagery Rehearsal Therapy and Targeted memory reactivation during REM sleep, Imagery Rehearsal Therapy
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University Hospital, Geneva
Surgery
Improving Perioperative Antimicrobial Prophylaxis by the Use of a Computerized Decision Support System
To evaluate the impact of using a computerized decision program on the adequacy of the perioperative antimicrobial prophylaxis
- Trial name
- eSATP (NCT03456635)
- Testing
- guided antimicrobial prophylaxis
- Where
- Switzerland
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Interaction, Pain
Impact of CYP2D6 Genetic Polymorphisms on the Vulnerability to Drug-drug Interactions With Tramadol
Despite its poor abundance in the liver, CYP2D6 is the second most important CYP in drug metabolism, metabolizing 20% of drugs. The high inter-individual variability in CYP2D6 expression is explained by genetic variations, but…
- Trial name
- PREDICT (NCT04249674)
- Testing
- Dextrometorphan, Genotyping by single nulcetoide polymorphism.
- Where
- Switzerland
- Volunteers
- 172 people
- Sponsor
- University Hospital, Geneva
Pertussis, Vaccine-Preventable Diseases
Safety and Immunogenicity of 2 Doses Versus 1 Dose of Acellular Pertussis Vaccines Containing Genetically-detoxified Pertussis Toxin in Young Adults Previously Primed With Acellular Pertussis Vaccines
A significant increase of pertussis incidence is reported in a growing number of countries. This resurgence is considered as resulting from the limited durability of aP-vaccine-induced immunity and is associated with increased…
- Trial name
- Pertagen2x (NCT05193734)
- Testing
- Pertagen®, Revaxis®
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Contraception, Progestogen Adverse Reaction
Does Oral Desogestrel Prior to Insertion of the Etonogestrel Subdermal Implant Improve Continuation Rate at One Year?
Objective: The etonogestrel subdermal implant (ESI) is an effective and safe method of contraception. Although highly efficient, ESI produces often side effects that reduce its tolerance and acceptance.
- Trial name
- NCT05174195
- Testing
- Desogestrel 0.075 milligram, Implanon NXT® subdermal implant
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Home Non-Invasive Ventilation
The Geneva Lake Study Update : An Overview of Home Non-Invasive Ventilation 15 Years Later
A multicenter cross-sectional observational study was conducted in the counties of Geneva and Vaud (1'271'957 inhabitants in 2016 and 1'288'090 inhabitants in 2017 ) and included all subjects under home NIV followed by the two…
- Trial name
- NCT04054570
- Testing
- No intervention
- Volunteers
- 947 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
COPD
Early Palliative Care for Patients With Severe and Very Severe COPD: a Randomised Study
Chronic obstructive pulmonary disease (COPD) is a common and, despite existing treatment options, progressive lung disease. Patients with COPD often have only limited access to palliative care.
- Trial name
- NCT02223780
- Testing
- early palliative care
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University Hospital, Geneva
Obesity-hypoventilation Syndrome, Resting Energy Expenditure
Resting Energy Expenditure in Patients With OHS Treated With Long-term NIV
This study aims to compare, in subjects with obesity-hypoventilation syndrome (OHS) treated by long-term non-invasive ventilation (NIV), resting energy expenditure (REE) in spontaneous breathing and under NIV.
- Conditions
- Obesity-hypoventilation Syndrome, Resting Energy Expenditure, Long-term Non-invasive Ventilation
- Trial name
- NCT04474587
- Testing
- Indirect calorimetry
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
COVID-19 Pandemic, Vulnerable Subjects
Perceived Impact of the COVID-19 Pandemic on Medical Management and Symptoms in a High Risk Group
The Swiss population underwent a period of confinement related to the COVID-19 pandemic (March 16 to May 11, 2020) decided by the Swiss Federal Government.
- Conditions
- COVID-19 Pandemic, Vulnerable Subjects, Long-term Non-invasive Ventilation
- Trial name
- NCT04477473
- Testing
- Questionnaire-based observational study
- Where
- Switzerland
- Volunteers
- 66 people
- Sponsor
- University Hospital, Geneva
Pneumonia
The Place of Imaging and Microbiology in the Diagnosis of Pneumonia in the Elderly
Diagnosis of pneumonia in the elderly is difficult because of the poor sensitivity and specificity of clinical signs as well as images from chest radiography (RT).
- Trial name
- PneumOldCT (NCT02467192)
- Testing
- Low dose CT
- Where
- Switzerland
- Volunteers
- 203 people
- Sponsor
- University Hospital, Geneva
Inhibition
Exploring the Impact of Biofeedback on the Inhibitory Control of Healthy Older Adults
Inhibitory control refers to the conscious and voluntary suppression of predominant responses when they are automatic, inappropriate, or incorrect.
- Trial name
- I-BF (NCT04925830)
- Testing
- Heart rate variability biofeedback; haemoncephalography biofeedback
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva