Clinical trials: open to volunteers, sponsored by University Hospital, Geneva
Apnea of Prematurity
nCPAP-NAVA-Backup Versus Standard nCPAP for Severe Apnea in Preterm Infants ≤28 Weeks
The goal of this clinical trial is to determine whether nasal continuous positive airway pressure (nCPAP) with neurally adjusted ventilatory assist (NAVA) backup ventilation (nCPAP-NAVA-backup mode) reduces the rate of severe…
- Trial name
- NAVAPNEA (NCT07923604)
- Testing
- nCPAP-NAVA-backup mode, nCPAP mode
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University Hospital, Geneva
Coronary Artery Disease, Diffuse Coronary Artery Disease
Hybrid Percutaneous Coronary Intervention Combining a Bioresorbable Scaffold With Drug-coated Balloons Versus a Conventional Drug-eluting Stent-based Strategy in Patients With Long and Diffuse Coronary Artery Disease
The primary objective of the study is to assess the safety and the efficacy of a hybrid percutaneous coronary intervention (PCI) strategy combining a magnesium-based sirolimus-eluting bioresorbable scaffold (Freesolve, Biotronik…
- Conditions
- Coronary Artery Disease, Diffuse Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
- Trial name
- BIOHYBRID (NCT06710210)
- Testing
- PCI with a bioresorbable scaffold and drug-coated balloon(s), PCI with drug-eluting stent(s)
- Where
- 4 sites in Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Geneva
Perineal Trauma, Postpartum Pain
RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy
Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.
- Conditions
- Perineal Trauma, Postpartum Pain, Episiotomy, Perineal Laceration
- Trial name
- RELIEVE (NCT07727213)
- Testing
- Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Wound Healing, Wound Healing Complication
Association Between Female Hormonal Profile and Wound Healing
The goal of this observational study is to assess the relationship between female hormonal status and postoperative wound healing in reduction mammaplasty. The main questions it aims to answer are: 1.
- Conditions
- Wound Healing, Wound Healing Complication, Estradiol
- Trial name
- FEMHEAL (NCT07724145)
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- University Hospital, Geneva
Cancer (With or Without Metastasis), Interstitial Lung Disease (ILD)
Hypnosis on Breathlessness Mastery in Patients With Persistent Dyspnea
Persistent dyspnea is a debilitating symptom, that is common and difficult to treat. This symptom is found in many different diseases including chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD)…
- Conditions
- Cancer (With or Without Metastasis), Interstitial Lung Disease (ILD), Chronic Heart Failure (CHF), COPD
- Trial name
- HYPNEA (NCT07173348)
- Testing
- Hypnosis
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- University Hospital, Geneva
Diabetes Mellitus, Type 1
Anhydroglucitol in Children With Type 1 Diabetes
The investigators will measure blood levels of 1,5-anhydroglucitol in children with type 1 diabetes and correlate them with parameters related to functional beta-cell mass in diabetic patients.
- Trial name
- NCT05594706
- Testing
- Measurement of blood levels of 1,5-anhydroglucitol
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Breast Reconstruction, Lipofilling
Hyperbaric Oxygen Therapy to Improve Autologous Fat Graft Intake in Irradiated Breast
The goal of this clinical trial is to learn if hyperbaric oxygen therapy (HBOT) enhances fat graft survival in lipofilling procedures in irradiated breast cancer patients.
- Conditions
- Breast Reconstruction, Lipofilling, Hyperbaric Oxygen Therapy
- Trial name
- NCT07140198
- Testing
- Hyperbaric Oxygen Therapy, Control
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University Hospital, Geneva
Heavy Menstrual Bleeding, Bleeding Disorder
Hormonal Management of Heavy Menstrual Bleeding in Adolescents
The goal of this study is to evaluate whether hormonal medications (such as contraceptive pill, patch, injectable progestins and hormonal intra-uterine device) have similar efficacy at managing heavy menstrual bleeding in…
- Trial name
- JAdoRE (NCT06740929)
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- University Hospital, Geneva
Breast Cancer
Ablative SBRT in Elderly BC Patients
Stereotactic body radiotherapy (SBRT) is a modern radiotherapy technique, through which extremely high doses of irradiation are delivered in a very precise manner, within a few fractions.
- Trial name
- EASE (NCT06523894)
- Testing
- SBRT
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University Hospital, Geneva
Morbid Obesity Requiring Bariatric Surgery
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass.
- Trial name
- FLAG (NCT07565051)
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University Hospital, Geneva
Essential Tremor
Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor
The goal of this proof-of-concept study is to examine the effects of a relatively new, non-invasive electrical current-based technique, transcranial temporal interference stimulation (tTIS), in patients with Essential Tremor…
- Trial name
- TremorTIS (NCT07531238)
- Testing
- Transcranial temporal interference stimulation, Tremor monitoring through Inertial Measurement Units (IMUs)
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University Hospital, Geneva
Bleeding Disorder
Bleeding of Unknown Cause: a Swiss Case-control Study
The goal of this prospective cohort is to identified specific biological patterns in patients with a bleeding of unknown cause and to study the specific mechanisms of the bleeding disorder for each subset of patients.
- Trial name
- SWISS-BUC (NCT05713734)
- Testing
- Thrombin generation, Fibrinolysis, Fibrin clot structure
- Where
- 7 sites in Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Uterine Fibroid
The Impact of a Novel GnRH Antagonist With Add-back Therapy for Treatment of Uterine Fibroids and Endometriosis on Hemostasis Parameters
Uterine fibroids and endometriosis are two frequent diseases among women of reproductive age. They can be responsible for chronic and/or menstrual pelvic pain and abnormal uterine bleeding.
- Trial name
- NCT07173127
- Testing
- Ryeqo treatment
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia Grade 2 (CIN2)
Digital Telecytology for Triage of HPV-Positive Women in Cameroon
This study evaluates the diagnostic accuracy and feasibility of a same-day cervical cancer screening strategy using HPV self-sampling followed by digital telecytology triage among HPV-positive women in Cameroon.
- Conditions
- Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia Grade 2 (CIN2), Cervical Cancer Screening Methods
- Trial name
- NCT07550010
- Testing
- HPV testing (self-sampling), Digital telecytology, AI-assisted telecytology
- Where
- 2 sites in Cameroon
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Diabete Type 2, Regurgitation
Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors
Treatment with semaglutide slows down gastric emptying , food remains in the stomach for a longer period of time. This slowing has important implications for anesthesia management.
- Conditions
- Diabete Type 2, Regurgitation, Pulmonary Aspiration During Anaesthetic Induction
- Trial name
- SAGUSE (NCT07506356)
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University Hospital, Geneva
Infertility, Female
Impact of a Mindfulness Intervention on Infertile Women Undergoing Assisted Reproductive Technique Treatments
Infertility and its treatments can have a significant impact on women's psychological health. Anxiety has a negative impact on quality of life during treatment and can lead to withdrawal of care.
- Trial name
- EMOT-IVF (NCT04419740)
- Testing
- Mindfulness based psychological intervention
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Chronic Subdural Hematomas, Cerebral Compression Due to Injury
Middle Meningeal Artery Embolization for Chronic Subdural Hematomas (STORMM)
Chronic Subdural Hematomas (cSHD) are common, and due to cerebral compression, often result in neurological impairment and reduced consciousness. Surgery is typically performed once neurological symptoms develop.
- Trial name
- STORMM (NCT06163547)
- Testing
- MMA embolization
- Where
- 2 sites in Switzerland
- Volunteers
- 180 people
- Sponsor
- University Hospital, Geneva
Insomnia Disorder
Mental Imagery and Targeted Memory Reactivation in Insomnia
In this clinical trial, the investigators test whether mental Imagery Rescripting (IR), a technique where the individual is instructed to transform a negative memory or image into a positive one, and olfactory Targeted Memory…
- Trial name
- NCT06335784
- Testing
- Imagery Rescripting (IR), Imagery Rescripting (IR) and Targeted Memory Reactivation (TMR) during sleep, Sleep Hygiene
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Geneva
Rehabilitation Exercise, Oncologic Diseases
Home-Based Physiotherapy in Oncology
The goal of this clinical trial is to assess the feasibility, acceptability, and safety of a supervised home-based physiotherapy programme for adult oncology patients.
- Trial name
- NCT07440433
- Testing
- Home-based cycling + resistance training with physiotherapist supervision
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University Hospital, Geneva