Clinical trials: sponsored by University Hospital, Ghent
Paracetamol, Cefazolin
Paracetamol and Cefazolin Pharmacokinetics in Normal Weight and Overweight Children
Pharmacokinetic evaluations will be conducted to characterize the cefazolin plasma concentration-time profile, cefazolin penetration into subcutaneous adipose tissue, and paracetamol metabolization as assessed through blood…
- Trial name
- TISSUE (NCT07585487)
- Testing
- Cefazolin, Paracetamol (drug)
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Ghent
Colorectal Cancer
Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score
Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer related death. It can be prevented by endoscopic detection and complete resection of colorectal polyps.
- Trial name
- CRIS (NCT07584486)
- Testing
- Learning tool (CRIS/JNET), Learning tool (JNET/CRIS)
- Where
- Belgium
- Volunteers
- 764 people
- Sponsor
- University Hospital, Ghent
Oligometastatic Prostate Cancer (OMPC), Prostate Cancer (Adenocarcinoma)
Percutaneous Thermo-ablation for the Treatment of Prostate Cancer Oligometastatasis (TA-P-OLIM)
The TA-P-OLIM Study (Percutaneous Thermo-Ablation of Prostate Cancer OligoMetastasis) is a prospective, interventional phase II study designed to evaluate the feasibility, efficacy, and safety of percutaneous thermal ablation…
- Conditions
- Oligometastatic Prostate Cancer (OMPC), Prostate Cancer (Adenocarcinoma), Ablation Techniques
- Trial name
- TA-P-OLIM (NCT07237399)
- Testing
- Thermal ablation
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Oncologic Diseases, Cancer
Implementation and Evaluation of a Program Aimed at Facilitating Palliative Care Conversations
Cancer is one of the leading causes of death worldwide. In the care of people with cancer, it is essential to pay sufficient attention to individual care needs and quality of life.
- Trial name
- MCMV (NCT07402057)
- Testing
- My Care My Voice Intervention
- Where
- 4 sites in Belgium
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Decision Making ,Shared, Leadership
Coaching Doctors and Nurses to Improve Ethical Decision-making in Team
Literature and a pilot study performed in 2019 indicate room for enhancing openness to discuss ethical sensitive issues within and between teams, and improving goal-oriented care and decision-making for the benefit of the patient…
- Conditions
- Decision Making ,Shared, Leadership, End of Life Communication, End of Life Decision Making
- Trial name
- CODE II (NCT07327450)
- Testing
- Usual Care Group, CODE II intervention
- Where
- Belgium
- Volunteers
- 360 people
- Sponsor
- University Hospital, Ghent
Repetitive Negative Thinking, Healthy Controls Group - Age and Sex-matched
Emotion Regulation in RNT
The goal of this study is to understand why some people become stuck in repetitive negative thinking, which is common among individuals with depression and anxiety.
- Trial name
- NCT07513766
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection
Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.
This prospective observational diagnostic study aims to improve the accuracy and timeliness of diagnosing chronic periprosthetic joint infection (PJI).
- Conditions
- Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection, Prosthetic Joint Failure of Unclear Etiology
- Trial name
- PJI MAP/DEF (NCT07494630)
- Testing
- Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- University Hospital, Ghent
IVF, Embryo Loss
Luteal Support in Artificial Vitrified/Warmed Cycles With Low Progesterone
The study aims to evaluate the effect of an increased dose of vaginal progesterone supplementation on the incidence of ongoing pregnancy for patients with a suboptimal serum progesterone level (defined as < 10 mcg/l) on the day…
- Conditions
- IVF, Embryo Loss, Luteal Phase Defect
- Trial name
- PROTECTA (NCT04806919)
- Testing
- Progesteron TID
- Where
- 2 sites in Belgium
- Volunteers
- 87 people
- Sponsor
- University Hospital, Ghent
Type 2 Diabetes Mellitus (T2DM)
Polyphenol Metabotypes in People With Diabetes Type 2
This cross-sectional study seeks to characterize the overall polyphenol metabotype in patients with T2DM in comparison to age-matched individuals without diabetes.
- Trial name
- PPPIL (NCT06810635)
- Testing
- Oral Polyphenol Challenge Test / PPPIL, fasting blood sample, Fasting urine collection
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Medium Chain Acyl CoA Dehydrogenase Deficiency
High Intensity Exercise in Children With MCADD
Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a rare genetic disorder affecting the body's ability to break down certain fats (β-oxidation) for energy, leading to symptoms like hypoketotic hypoglycaemia, jaundice…
- Trial name
- MCADD-EX (NCT06796530)
- Testing
- Cardiopulmonary exercise test (CPET), High-intensity circuit training
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Osteogenesis Imperfecta, Type I
An Interventional Study to Evaluate the Impact of Blood Flow Restriction Training on Muscle, Bone, and Quality of Life in Adults With Osteogenesis Imperfecta Type I
Background: Due to fear of injury and risk of fractures, many people with osteogenesis imperfecta (OI) avoid vigorous exercise that is likely to improve muscle and bone weakness common in this disorder.
- Trial name
- NCT07478224
- Testing
- Blood flow restriction training
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Graves Orbitopathy, Hyperthyroidism
Development of a Non-Invasive Prognostic Test for Graves Orbitopathy
The aim of this research project is to develop a non-invasive, simple, robust, and sensitive prognostic test that can identify hyperthyroidism patients who are at risk of developing Graves' Orbitopathy.
- Trial name
- GoPro (NCT07472062)
- Testing
- Schirmer's test
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Dry Eye Disease
Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST)
A prospective, single-blinded, randomized, controlled crossover trial was conducted in patients with severe dry eye syndrome. Topical treatment with autologous serum eye drops (ASED) diluted at 20%, undiluted ASED and…
- Trial name
- AST (NCT07469865)
- Testing
- Preservative-free artificial tears, Autologous serum eyedrops 20%, Autologous serum eyedrops 100%
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University Hospital, Ghent
Active tDCS, Sham tDCS
Combination of Neurostimulation and Psychotherapy to Stop Worrying
This study aims to investigate whether the combination of transcranial Direct Current Stimulation (tDCS) and cognitive-behavioral therapy (CBT) is more effective for treating repetitive negative thinking (RNT) in patients with…
- Trial name
- NCT06369532
- Testing
- Active tDCS
- Where
- Belgium
- Volunteers
- 85 people
- Sponsor
- University Hospital, Ghent
Pediatric, Efficiency
Optimisation of Solute Removal and Water Usage in Paediatric Haemodialysis
Children receiving chronic haemodialysis are typically treated with dialysis machines designed for adult patients. As a result, some devices do not allow the ideal blood or dialysate flow rates to be set for paediatric use.
- Conditions
- Pediatric, Efficiency, Hemodialysis Patient, Hemodialysis Treatment
- Trial name
- OptiPed (NCT07466459)
- Testing
- blood and dialysate sampling
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
Psoriasis Vulgaris
Proactive TDM Versus Standard Use of Biologics in Psoriasis
Biologics are effective agents for the treatment of psoriasis. The newest generation of biologics block interleukin 17 and 23. Physicians always prescribe these drugs in a fixed dose, but this may lead to under- and overdosing in…
- Trial name
- HELIOS (NCT06398106)
- Testing
- Proactive TDM-based dosing of secukinumab, Proactive TDM-based dosing of ixekizumab, Proactive TDM-based dosing of guselkumab
- Where
- 15 sites in Belgium
- Volunteers
- 210 people
- Sponsor
- University Hospital, Ghent
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Resuscitated Sudden Cardiac Death
- Trial name
- Lazarus-AOI (NCT07438938)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Breast Neoplasm, Radiotherapy
HOBBIT 3: Mental Exercises and Temporal Alteration
In the HOBBIT-trial by Vakaet et al. A protocol was developed to increase breath-hold time using (voluntary) hyperventilation and oxygenation to achieve DIBH times around 3 minutes.
- Conditions
- Breast Neoplasm, Radiotherapy, Breath Holding, Mental Test
- Trial name
- HOBBIT-META (NCT06100068)
- Testing
- Mental Exercises and Temporal Alteration
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Postoperative Ileus
Use of Beetroot Juice to Protect Against Postoperative Ileus Following Colorectal Surgery: BEET IT Study
The goal of the BEET IT study is to examine if preoperative intake of beetroot juice can ameliorate gastrointestinal (GI) recovery after colorectal surgery and thereby help to reduce the duration of postoperative ileus (POI) and…
- Trial name
- BEET IT (NCT05133024)
- Testing
- concentrated beetroot juice
- Where
- 6 sites in Belgium
- Volunteers
- 170 people
- Sponsor
- University Hospital, Ghent
Non-binary
Knowledge About and Attitudes Towards Non-binary Persons in Flanders (Part 1: Quantitative Study)
The goal of this observational study is to investigate the knowledge about and attitudes towards non-binary individuals in Flemish adults.
- Trial name
- NCT07400887
- Where
- Belgium
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent